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Pathogenesis and Immunity

Effects of Alpha Interferon Treatment on Intrinsic Anti-HIV-1 Immunity In Vivo

Mohamed Abdel-Mohsen, Xutao Deng, Teri Liegler, John C. Guatelli, Mohamed S. Salama, Hussam El-din A. Ghanem, Andri Rauch, Bruno Ledergerber, Steven G. Deeks, Huldrych F. Günthard, Joseph K. Wong, Satish K. Pillai
Mohamed Abdel-Mohsen
aDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA
dFaculty of Science, Ain Shams University, Cairo, Egypt
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Xutao Deng
bBlood Systems Research Institute, San Francisco, California, USA
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Teri Liegler
aDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA
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John C. Guatelli
cUniversity of California, San Diego, La Jolla, California, and VA San Diego Healthcare System, San Diego, California, USA
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Mohamed S. Salama
dFaculty of Science, Ain Shams University, Cairo, Egypt
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Hussam El-din A. Ghanem
dFaculty of Science, Ain Shams University, Cairo, Egypt
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Andri Rauch
eDepartment of Infectious Diseases, Bern University Hospital and University of Bern, Bern, Switzerland
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Bruno Ledergerber
fDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
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Steven G. Deeks
aDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA
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Huldrych F. Günthard
fDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
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Joseph K. Wong
aDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA
gDepartment of Medicine, San Francisco VA Medical Center, San Francisco, California, USA
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Satish K. Pillai
aDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA
bBlood Systems Research Institute, San Francisco, California, USA
gDepartment of Medicine, San Francisco VA Medical Center, San Francisco, California, USA
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DOI: 10.1128/JVI.02687-13
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ABSTRACT

Alpha interferon (IFN-α) suppresses human immunodeficiency virus type 1 (HIV-1) replication in vitro by inducing cell-intrinsic retroviral restriction mechanisms. We investigated the effects of IFN-α/ribavirin (IFN-α/riba) treatment on 34 anti-HIV-1 restriction factors in vivo. Expression of several anti-HIV-1 restriction factors was significantly induced by IFN-α/riba in HIV/hepatitis C virus (HCV)-coinfected individuals. Fold induction of cumulative restriction factor expression in CD4+ T cells was significantly correlated with viral load reduction during IFN-α/riba treatment (r 2 = 0.649; P < 0.016). Exogenous IFN-α induces supraphysiologic restriction factor expression associated with a pronounced decrease in HIV-1 viremia.

FOOTNOTES

    • Received 17 September 2013.
    • Accepted 17 October 2013.
    • Accepted manuscript posted online 23 October 2013.
  • Address correspondence to Satish K. Pillai, satish.pillai{at}ucsf.edu.
  • Supplemental material for this article may be found at http://dx.doi.org/10.1128/JVI.02687-13.

  • Copyright © 2014, American Society for Microbiology. All Rights Reserved.
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Effects of Alpha Interferon Treatment on Intrinsic Anti-HIV-1 Immunity In Vivo
Mohamed Abdel-Mohsen, Xutao Deng, Teri Liegler, John C. Guatelli, Mohamed S. Salama, Hussam El-din A. Ghanem, Andri Rauch, Bruno Ledergerber, Steven G. Deeks, Huldrych F. Günthard, Joseph K. Wong, Satish K. Pillai
Journal of Virology Dec 2013, 88 (1) 763-767; DOI: 10.1128/JVI.02687-13

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Effects of Alpha Interferon Treatment on Intrinsic Anti-HIV-1 Immunity In Vivo
Mohamed Abdel-Mohsen, Xutao Deng, Teri Liegler, John C. Guatelli, Mohamed S. Salama, Hussam El-din A. Ghanem, Andri Rauch, Bruno Ledergerber, Steven G. Deeks, Huldrych F. Günthard, Joseph K. Wong, Satish K. Pillai
Journal of Virology Dec 2013, 88 (1) 763-767; DOI: 10.1128/JVI.02687-13
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