FIG. 6.

Polyfunctional mucosal CD4⁺ T-cell responses correlate with the magnitude and polyfunctionality of the CD8⁺ T-cell response. Relationships between the magnitude of the total CD4⁺ T-cell response and the magnitude of the total CD8⁺ T-cell response (A), the frequency of the polyfunctional CD4⁺ T cells and the magnitude of the total CD8⁺ T-cell response (B), and the frequency of the polyfunctional CD4⁺ T cells and the frequency of the polyfunctional CD8⁺ T cells (C) in rectal mucosa of controllers and noncontrollers. Polyfunctional CD4⁺ T cells are defined as exhibiting 3 or 4 functional responses; polyfunctional CD8⁺ T cells are those which express 3, 4, or 5 functions. Linear-regression lines and Spearman's r correlations were calculated using the combined controller and noncontroller data set.