FIG. 6.
Polyfunctional mucosal CD4+ T-cell responses correlate with the magnitude and polyfunctionality of the CD8+ T-cell response. Relationships between the magnitude of the total CD4+ T-cell response and the magnitude of the total CD8+ T-cell response (A), the frequency of the polyfunctional CD4+ T cells and the magnitude of the total CD8+ T-cell response (B), and the frequency of the polyfunctional CD4+ T cells and the frequency of the polyfunctional CD8+ T cells (C) in rectal mucosa of controllers and noncontrollers. Polyfunctional CD4+ T cells are defined as exhibiting 3 or 4 functional responses; polyfunctional CD8+ T cells are those which express 3, 4, or 5 functions. Linear-regression lines and Spearman's r correlations were calculated using the combined controller and noncontroller data set.