FIG. 2.

HIV Gag-specific CD4⁺ T-cell polyfunctional responses in rectal mucosa and peripheral blood across subject groups. CD4⁺ T-cell polyfunctional responses in the rectal mucosa (A) and peripheral blood (B) of controllers, noncontrollers, and HAART-suppressed individuals. Colors in the pie charts represent 4-function cells (black), 3-function cells (purple), 2-function cells (dark blue), and 1-function cells (light blue). Values in the pie charts are the median total CD4⁺ T-cell response within each subject group. The bar charts below show the responses in controllers, noncontrollers, and HAART-suppressed individuals, broken down into individual functional categories using interquartile ranges. Asterisks below the bar charts show significant differences (P < 0.05; Wilcoxon rank test) between controllers and noncontrollers (red) or subjects on HAART (green).