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Genetic Diversity and Evolution

Phylogeny-Based Evolutionary, Demographical, and Geographical Dissection of North American Type 2 Porcine Reproductive and Respiratory Syndrome Viruses

Mang Shi, Tommy Tsan-Yuk Lam, Chung-Chau Hon, Michael P. Murtaugh, Peter R. Davies, Raymond Kin-Hei Hui, Jun Li, Lina Tik-Wim Wong, Chi-Wai Yip, Jin-Wai Jiang, Frederick Chi-Ching Leung
Mang Shi
1School of Biological Sciences, The University of Hong Kong, Hong Kong, China
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Tommy Tsan-Yuk Lam
1School of Biological Sciences, The University of Hong Kong, Hong Kong, China
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Chung-Chau Hon
1School of Biological Sciences, The University of Hong Kong, Hong Kong, China
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Michael P. Murtaugh
2Departments of Veterinary and Biomedical Sciences
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Peter R. Davies
3Veterinary Population Medicine, University of Minnesota, St. Paul, Minnesota
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Raymond Kin-Hei Hui
1School of Biological Sciences, The University of Hong Kong, Hong Kong, China
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Jun Li
1School of Biological Sciences, The University of Hong Kong, Hong Kong, China
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Lina Tik-Wim Wong
1School of Biological Sciences, The University of Hong Kong, Hong Kong, China
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Chi-Wai Yip
1School of Biological Sciences, The University of Hong Kong, Hong Kong, China
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Jin-Wai Jiang
1School of Biological Sciences, The University of Hong Kong, Hong Kong, China
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Frederick Chi-Ching Leung
1School of Biological Sciences, The University of Hong Kong, Hong Kong, China
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  • For correspondence: fcleung@hkucc.hku.hk
DOI: 10.1128/JVI.02551-09
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ABSTRACT

Type 2 (or North American-like) porcine reproductive and respiratory syndrome virus (PRRSV) was first recorded in 1987 in the United States and now occurs in most commercial swine industries throughout the world. In this study, we investigated the epidemiological and evolutionary behaviors of type 2 PRRSV. Based on phylogenetic analyses of 8,624 ORF5 sequences, we described a comprehensive picture of the diversity of type 2 PRRSVs and systematically classified all available sequences into lineages and sublineages, including a number of previously undescribed lineages. With the rapid growth of sequence deposition into the databases, it would be technically difficult for veterinary researchers to genotype their sequences by reanalyzing all sequences in the databases. To this end, a set of reference sequences was established based on our classification system, which represents the principal diversity of all available sequences and can readily be used for further genotyping studies. In addition, we further investigated the demographic histories of these lineages and sublineages by using Bayesian coalescence analyses, providing evolutionary insights into several important epidemiological events of type 2 PRRSV. Moreover, by using a phylogeographic approach, we were able to estimate the transmission frequencies between the pig-producing states in the United States and identified several states as the major sources of viral spread, i.e., “transmission centers.” In summary, this study represents the most extensive phylogenetic analyses of type 2 PRRSV to date, providing a basis for future genotyping studies and dissecting the epidemiology of type 2 PRRSV from phylogenetic perspectives.

  • Copyright © 2010 American Society for Microbiology
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Phylogeny-Based Evolutionary, Demographical, and Geographical Dissection of North American Type 2 Porcine Reproductive and Respiratory Syndrome Viruses
Mang Shi, Tommy Tsan-Yuk Lam, Chung-Chau Hon, Michael P. Murtaugh, Peter R. Davies, Raymond Kin-Hei Hui, Jun Li, Lina Tik-Wim Wong, Chi-Wai Yip, Jin-Wai Jiang, Frederick Chi-Ching Leung
Journal of Virology Aug 2010, 84 (17) 8700-8711; DOI: 10.1128/JVI.02551-09

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Phylogeny-Based Evolutionary, Demographical, and Geographical Dissection of North American Type 2 Porcine Reproductive and Respiratory Syndrome Viruses
Mang Shi, Tommy Tsan-Yuk Lam, Chung-Chau Hon, Michael P. Murtaugh, Peter R. Davies, Raymond Kin-Hei Hui, Jun Li, Lina Tik-Wim Wong, Chi-Wai Yip, Jin-Wai Jiang, Frederick Chi-Ching Leung
Journal of Virology Aug 2010, 84 (17) 8700-8711; DOI: 10.1128/JVI.02551-09
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  • Top
  • Article
    • ABSTRACT
    • Classification and epidemiology of type 2 PRRSV.
    • Problems of live attenuated vaccines.
    • Long-distance dissemination of PRRSV.
    • Motivations of this study.
    • MATERIALS AND METHODS
    • RESULTS AND DISCUSSION
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
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  • Info & Metrics
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KEYWORDS

Evolution, Molecular
phylogeny
Porcine Reproductive and Respiratory Syndrome
Porcine respiratory and reproductive syndrome virus

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