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Genome Replication and Regulation of Viral Gene Expression

Inhibition of Dengue Virus Polymerase by Blocking of the RNA Tunnel

Pornwaratt Niyomrattanakit, Yen-Liang Chen, Hongping Dong, Zheng Yin, Min Qing, J. Frasier Glickman, Kai Lin, Dieter Mueller, Hans Voshol, Joanne Y. H. Lim, Shahul Nilar, Thomas H. Keller, Pei-Yong Shi
Pornwaratt Niyomrattanakit
1Novartis Institute for Tropical Diseases, 10 Biopolis Road, #05-01 Chromos, Singapore
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Yen-Liang Chen
1Novartis Institute for Tropical Diseases, 10 Biopolis Road, #05-01 Chromos, Singapore
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Hongping Dong
1Novartis Institute for Tropical Diseases, 10 Biopolis Road, #05-01 Chromos, Singapore
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Zheng Yin
1Novartis Institute for Tropical Diseases, 10 Biopolis Road, #05-01 Chromos, Singapore
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Min Qing
1Novartis Institute for Tropical Diseases, 10 Biopolis Road, #05-01 Chromos, Singapore
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J. Frasier Glickman
2Novartis Institutes for BioMedical Research, Basel CH4002, Switzerland
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Kai Lin
3Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139
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Dieter Mueller
2Novartis Institutes for BioMedical Research, Basel CH4002, Switzerland
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Hans Voshol
2Novartis Institutes for BioMedical Research, Basel CH4002, Switzerland
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Joanne Y. H. Lim
1Novartis Institute for Tropical Diseases, 10 Biopolis Road, #05-01 Chromos, Singapore
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Shahul Nilar
1Novartis Institute for Tropical Diseases, 10 Biopolis Road, #05-01 Chromos, Singapore
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Thomas H. Keller
1Novartis Institute for Tropical Diseases, 10 Biopolis Road, #05-01 Chromos, Singapore
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Pei-Yong Shi
1Novartis Institute for Tropical Diseases, 10 Biopolis Road, #05-01 Chromos, Singapore
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  • For correspondence: pei_yong.shi@novartis.com
DOI: 10.1128/JVI.02451-09
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Article Information

DOI 
https://doi.org/10.1128/JVI.02451-09
PubMed 
20237086

Published By 
American Society for Microbiology Journals
History 
  • Received November 20, 2009
  • Accepted March 9, 2010
  • Published online May 4, 2010.

Copyright & Usage 
Copyright © 2010 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (March 17, 2010).
  • You are viewing the most recent version of this article.

Author Information

  1. Pornwaratt Niyomrattanakit1†,
  2. Yen-Liang Chen1†,
  3. Hongping Dong1,
  4. Zheng Yin1‡,
  5. Min Qing1,
  6. J. Frasier Glickman2§,
  7. Kai Lin3,
  8. Dieter Mueller2,
  9. Hans Voshol2,
  10. Joanne Y. H. Lim1,
  11. Shahul Nilar1,
  12. Thomas H. Keller1 and
  13. Pei-Yong Shi1*
  1. 1Novartis Institute for Tropical Diseases, 10 Biopolis Road, #05-01 Chromos, Singapore
  2. 2Novartis Institutes for BioMedical Research, Basel CH4002, Switzerland
  3. 3Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139
  • ↵† P.N. and Y.-L.C. contributed equally to this study.

  • ↵* Corresponding author. Mailing address: 10 Biopolis Road, #05-01 Chromos, Singapore 138670. Phone: (65) 67222909. Fax: (65) 67222916. E-mail: pei_yong.shi{at}novartis.com
  • ↵‡ Present address: College of Pharmacy and The State Key Laboratory of Elemento-Organic chemistry, Nankai University, Tianjin 300071, China.; § Present address: High Throughput Screening Resource Center, The Rockefeller University, 1230 York Avenue, Box 203, New York, NY 10065.

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Inhibition of Dengue Virus Polymerase by Blocking of the RNA Tunnel
Pornwaratt Niyomrattanakit, Yen-Liang Chen, Hongping Dong, Zheng Yin, Min Qing, J. Frasier Glickman, Kai Lin, Dieter Mueller, Hans Voshol, Joanne Y. H. Lim, Shahul Nilar, Thomas H. Keller, Pei-Yong Shi
Journal of Virology May 2010, 84 (11) 5678-5686; DOI: 10.1128/JVI.02451-09

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Inhibition of Dengue Virus Polymerase by Blocking of the RNA Tunnel
Pornwaratt Niyomrattanakit, Yen-Liang Chen, Hongping Dong, Zheng Yin, Min Qing, J. Frasier Glickman, Kai Lin, Dieter Mueller, Hans Voshol, Joanne Y. H. Lim, Shahul Nilar, Thomas H. Keller, Pei-Yong Shi
Journal of Virology May 2010, 84 (11) 5678-5686; DOI: 10.1128/JVI.02451-09
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KEYWORDS

antiviral agents
dengue
RNA replicase
ortho-Aminobenzoates

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