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Pathogenesis and Immunity

Reduced Viral Replication Capacity of Human Immunodeficiency Virus Type 1 Subtype C Caused by Cytotoxic-T-Lymphocyte Escape Mutations in HLA-B57 Epitopes of Capsid Protein

Christian L. Boutwell, Christopher F. Rowley, M. Essex
Christian L. Boutwell
1Department of Immunology and Infectious Diseases
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Christopher F. Rowley
1Department of Immunology and Infectious Diseases
2Harvard School of Public Health AIDS Initiative, Harvard School of Public Health, 651 Huntington Avenue, Boston, Massachusetts 02115
3Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Lowry Building, Suite GB, 110 Francis Street, Boston, Massachusetts 02215
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M. Essex
1Department of Immunology and Infectious Diseases
2Harvard School of Public Health AIDS Initiative, Harvard School of Public Health, 651 Huntington Avenue, Boston, Massachusetts 02115
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  • For correspondence: messex@hsph.harvard.edu
DOI: 10.1128/JVI.01970-08
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Article Information

DOI 
https://doi.org/10.1128/JVI.01970-08
PubMed 
19109381

Published By 
American Society for Microbiology Journals
History 
  • Received September 18, 2008
  • Accepted December 19, 2008
  • Published online February 24, 2009.

Copyright & Usage 
Copyright © 2009 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (December 24, 2008).
  • You are viewing the most recent version of this article.

Author Information

  1. Christian L. Boutwell1,
  2. Christopher F. Rowley1,2,3 and
  3. M. Essex1,2*
  1. 1Department of Immunology and Infectious Diseases
  2. 2Harvard School of Public Health AIDS Initiative, Harvard School of Public Health, 651 Huntington Avenue, Boston, Massachusetts 02115
  3. 3Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Lowry Building, Suite GB, 110 Francis Street, Boston, Massachusetts 02215
  • ↵* Corresponding author. Mailing address: 651 Huntington Avenue, FXB 402, Boston, MA 02115. Phone: (617) 432-2334. Fax: (617) 739-8348. E-mail: messex{at}hsph.harvard.edu

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Reduced Viral Replication Capacity of Human Immunodeficiency Virus Type 1 Subtype C Caused by Cytotoxic-T-Lymphocyte Escape Mutations in HLA-B57 Epitopes of Capsid Protein
Christian L. Boutwell, Christopher F. Rowley, M. Essex
Journal of Virology Feb 2009, 83 (6) 2460-2468; DOI: 10.1128/JVI.01970-08

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Reduced Viral Replication Capacity of Human Immunodeficiency Virus Type 1 Subtype C Caused by Cytotoxic-T-Lymphocyte Escape Mutations in HLA-B57 Epitopes of Capsid Protein
Christian L. Boutwell, Christopher F. Rowley, M. Essex
Journal of Virology Feb 2009, 83 (6) 2460-2468; DOI: 10.1128/JVI.01970-08
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KEYWORDS

Capsid Proteins
epitopes
HIV-1
HLA-B Antigens
Mutation, Missense
T-Lymphocytes, Cytotoxic
virus replication

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