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Genetic Diversity and Evolution

Use of Massively Parallel Ultradeep Pyrosequencing To Characterize the Genetic Diversity of Hepatitis B Virus in Drug-Resistant and Drug-Naive Patients and To Detect Minor Variants in Reverse Transcriptase and Hepatitis B S Antigen

Mariacarmela Solmone, Donatella Vincenti, Mattia Carlo Felice Prosperi, Alessandro Bruselles, Giuseppe Ippolito, Maria Rosaria Capobianchi
Mariacarmela Solmone
National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
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Donatella Vincenti
National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
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Mattia Carlo Felice Prosperi
National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
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Alessandro Bruselles
National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
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Giuseppe Ippolito
National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
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Maria Rosaria Capobianchi
National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
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  • For correspondence: capobianchi@inmi.it
DOI: 10.1128/JVI.02011-08
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Article Information

DOI 
https://doi.org/10.1128/JVI.02011-08
PubMed 
19073746

Published By 
American Society for Microbiology Journals
History 
  • Received September 24, 2008
  • Accepted November 27, 2008
  • Published online January 27, 2009.

Copyright & Usage 
Copyright © 2009 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (December 10, 2008).
  • You are viewing the most recent version of this article.

Author Information

  1. Mariacarmela Solmone,
  2. Donatella Vincenti,
  3. Mattia Carlo Felice Prosperi,
  4. Alessandro Bruselles,
  5. Giuseppe Ippolito and
  6. Maria Rosaria Capobianchi*
  1. National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
  • ↵* Corresponding author. Mailing address: Laboratory of Virology, National Institute for Infectious Diseases (INMI) L. Spallanzani, Via Portuense 292, 00149 Rome, Italy. Phone: 390655170434. Fax: 39065594555. E-mail: capobianchi{at}inmi.it
  • † Supplemental material for this article may be found at http://jvi.asm.org/ .

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Use of Massively Parallel Ultradeep Pyrosequencing To Characterize the Genetic Diversity of Hepatitis B Virus in Drug-Resistant and Drug-Naive Patients and To Detect Minor Variants in Reverse Transcriptase and Hepatitis B S Antigen
Mariacarmela Solmone, Donatella Vincenti, Mattia Carlo Felice Prosperi, Alessandro Bruselles, Giuseppe Ippolito, Maria Rosaria Capobianchi
Journal of Virology Jan 2009, 83 (4) 1718-1726; DOI: 10.1128/JVI.02011-08

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Use of Massively Parallel Ultradeep Pyrosequencing To Characterize the Genetic Diversity of Hepatitis B Virus in Drug-Resistant and Drug-Naive Patients and To Detect Minor Variants in Reverse Transcriptase and Hepatitis B S Antigen
Mariacarmela Solmone, Donatella Vincenti, Mattia Carlo Felice Prosperi, Alessandro Bruselles, Giuseppe Ippolito, Maria Rosaria Capobianchi
Journal of Virology Jan 2009, 83 (4) 1718-1726; DOI: 10.1128/JVI.02011-08
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KEYWORDS

Drug Resistance, Viral
genetic variation
Hepatitis B
Hepatitis B Surface Antigens
hepatitis B virus
Sequence Analysis, DNA
Viral Proteins

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