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Genome Replication and Regulation of Viral Gene Expression

The Flexible Loop of the Human Cytomegalovirus DNA Polymerase Processivity Factor ppUL44 Is Required for Efficient DNA Binding and Replication in Cells

Gualtiero Alvisi, Daniela Martino Roth, Daria Camozzi, Gregory S. Pari, Arianna Loregian, Alessandro Ripalti, David A. Jans
Gualtiero Alvisi
1Dipartimento di Ematologia e Scienze Oncologiche L.A. Seragnoli, Università Degli Studi di Bologna, Bologna, Italy
2Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
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  • For correspondence: gualtiero_alvisi@med.uni-heidelberg.de
Daniela Martino Roth
2Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
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Daria Camozzi
1Dipartimento di Ematologia e Scienze Oncologiche L.A. Seragnoli, Università Degli Studi di Bologna, Bologna, Italy
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Gregory S. Pari
3Department of Microbiology and Immunology and the Cell and Molecular Biology Graduate Program, University of Nevada, Reno, Reno, Nevada
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Arianna Loregian
4Dipartimento di Istologia, Microbiologia e Biotecnologie Mediche, Università di Padova, Padua, Italy
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Alessandro Ripalti
5Azienda Ospedaliera Universitaria di Bologna Policlinico S. Orsola-Malpighi, Dipartimento di Ematologia, Oncologia e Medicina di Laboratorio-Unità Operativa di Microbiologia, Bologna, Italia
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David A. Jans
2Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
6ARC Centre of Excellence in Biotechnology and Development
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DOI: 10.1128/JVI.00669-09
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Article Information

DOI 
https://doi.org/10.1128/JVI.00669-09
PubMed 
19570866

Published By 
American Society for Microbiology Journals
History 
  • Received April 1, 2009
  • Accepted June 19, 2009
  • Published online August 19, 2009.

Copyright & Usage 
Copyright © 2009 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (July 01, 2009).
  • You are viewing the most recent version of this article.

Author Information

  1. Gualtiero Alvisi1,2*,
  2. Daniela Martino Roth2,
  3. Daria Camozzi1,
  4. Gregory S. Pari3,
  5. Arianna Loregian4,
  6. Alessandro Ripalti5† and
  7. David A. Jans2,6†
  1. 1Dipartimento di Ematologia e Scienze Oncologiche L.A. Seragnoli, Università Degli Studi di Bologna, Bologna, Italy
  2. 2Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
  3. 3Department of Microbiology and Immunology and the Cell and Molecular Biology Graduate Program, University of Nevada, Reno, Reno, Nevada
  4. 4Dipartimento di Istologia, Microbiologia e Biotecnologie Mediche, Università di Padova, Padua, Italy
  5. 5Azienda Ospedaliera Universitaria di Bologna Policlinico S. Orsola-Malpighi, Dipartimento di Ematologia, Oncologia e Medicina di Laboratorio-Unità Operativa di Microbiologia, Bologna, Italia
  6. 6ARC Centre of Excellence in Biotechnology and Development¶
  • ↵* Corresponding author. Mailing address: Department of Molecular Virology, University of Heidelberg, Im Neuenheimer Feld 345, Heidelberg 69120, Germany. Phone: 49 622156-6306. Fax: 49 622156-4570. E-mail: gualtiero_alvisi{at}med.uni-heidelberg.de
  • ↵† A.R. and D.A.J. contributed equally to this study.

  • ↵¶ http://www.newcastle.edu.au/centre/cbd .

  • ‡ Supplemental material for this article may be found at http://jvi.asm.org/.

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The Flexible Loop of the Human Cytomegalovirus DNA Polymerase Processivity Factor ppUL44 Is Required for Efficient DNA Binding and Replication in Cells
Gualtiero Alvisi, Daniela Martino Roth, Daria Camozzi, Gregory S. Pari, Arianna Loregian, Alessandro Ripalti, David A. Jans
Journal of Virology Aug 2009, 83 (18) 9567-9576; DOI: 10.1128/JVI.00669-09

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The Flexible Loop of the Human Cytomegalovirus DNA Polymerase Processivity Factor ppUL44 Is Required for Efficient DNA Binding and Replication in Cells
Gualtiero Alvisi, Daniela Martino Roth, Daria Camozzi, Gregory S. Pari, Arianna Loregian, Alessandro Ripalti, David A. Jans
Journal of Virology Aug 2009, 83 (18) 9567-9576; DOI: 10.1128/JVI.00669-09
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KEYWORDS

DNA
DNA replication
DNA-binding proteins
DNA-Directed DNA Polymerase
Viral Proteins

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