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Pathogenesis and Immunity

Influenza Virus Directly Infects Human Natural Killer Cells and Induces Cell Apoptosis

Huawei Mao, Wenwei Tu, Gang Qin, Helen Ka Wai Law, Sin Fun Sia, Ping-Lung Chan, Yinping Liu, Kwok-Tai Lam, Jian Zheng, Malik Peiris, Yu-Lung Lau
Huawei Mao
1Department of Pediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, People's Republic of China
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Wenwei Tu
1Department of Pediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, People's Republic of China
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  • For correspondence: wwtu@hkucc.hku.hk lauylung@hkucc.hku.hk
Gang Qin
1Department of Pediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, People's Republic of China
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Helen Ka Wai Law
1Department of Pediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, People's Republic of China
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Sin Fun Sia
1Department of Pediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, People's Republic of China
2Department of Microbiology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, People's Republic of China
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Ping-Lung Chan
1Department of Pediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, People's Republic of China
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Yinping Liu
1Department of Pediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, People's Republic of China
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Kwok-Tai Lam
1Department of Pediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, People's Republic of China
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Jian Zheng
1Department of Pediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, People's Republic of China
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Malik Peiris
2Department of Microbiology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, People's Republic of China
3HKU-Pasteur Research Centre, the University of Hong Kong, Hong Kong SAR, People's Republic of China
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Yu-Lung Lau
1Department of Pediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, People's Republic of China
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  • For correspondence: wwtu@hkucc.hku.hk lauylung@hkucc.hku.hk
DOI: 10.1128/JVI.00805-09
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Article Information

DOI 
https://doi.org/10.1128/JVI.00805-09
PubMed 
19587043

Published By 
American Society for Microbiology Journals
History 
  • Received April 21, 2009
  • Accepted June 30, 2009
  • Published online August 19, 2009.

Copyright & Usage 
Copyright © 2009 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (July 08, 2009).
  • You are viewing the most recent version of this article.

Author Information

  1. Huawei Mao1,
  2. Wenwei Tu1*,
  3. Gang Qin1,
  4. Helen Ka Wai Law1,
  5. Sin Fun Sia1,2,
  6. Ping-Lung Chan1,
  7. Yinping Liu1,
  8. Kwok-Tai Lam1,
  9. Jian Zheng1,
  10. Malik Peiris2,3 and
  11. Yu-Lung Lau1*
  1. 1Department of Pediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, People's Republic of China
  2. 2Department of Microbiology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, People's Republic of China
  3. 3HKU-Pasteur Research Centre, the University of Hong Kong, Hong Kong SAR, People's Republic of China
  • ↵* Corresponding author. Mailing address for Wenwei Tu: Department of Paediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Room L7-58, 7/F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong SAR, People's Republic of China. Phone: (852) 2855-4205. Fax: (852) 2855-1523. E-mail: wwtu{at}hkucc.hku.hk . Mailing address for Yu-Lung Lau: Department of Paediatrics & Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, People's Republic of China. Phone: (852) 2819-9357. Fax: (852) 2819-8142. E-mail: lauylung{at}hkucc.hku.hk

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Influenza Virus Directly Infects Human Natural Killer Cells and Induces Cell Apoptosis
Huawei Mao, Wenwei Tu, Gang Qin, Helen Ka Wai Law, Sin Fun Sia, Ping-Lung Chan, Yinping Liu, Kwok-Tai Lam, Jian Zheng, Malik Peiris, Yu-Lung Lau
Journal of Virology Aug 2009, 83 (18) 9215-9222; DOI: 10.1128/JVI.00805-09

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Influenza Virus Directly Infects Human Natural Killer Cells and Induces Cell Apoptosis
Huawei Mao, Wenwei Tu, Gang Qin, Helen Ka Wai Law, Sin Fun Sia, Ping-Lung Chan, Yinping Liu, Kwok-Tai Lam, Jian Zheng, Malik Peiris, Yu-Lung Lau
Journal of Virology Aug 2009, 83 (18) 9215-9222; DOI: 10.1128/JVI.00805-09
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KEYWORDS

apoptosis
Killer Cells, Natural
orthomyxoviridae
Virus Internalization

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