Early Upregulation of Acute Respiratory Distress Syndrome-Associated Cytokines Promotes Lethal Disease in an Aged-Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Infection

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina; Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington; Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands; and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina; Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington; Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands; and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina; Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington; Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands; and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina; Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington; Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands; and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina; Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington; Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands; and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina; Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington; Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands; and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina; Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington; Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands; and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina; Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington; Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands; and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina; Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington; Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands; and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina; Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington; Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands; and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina; Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington; Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands; and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina; Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington; Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands; and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina