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Virus-Cell Interactions | Spotlight

Splicing of the Large Intron Present in the Nonstructural Gene of Minute Virus of Mice Is Governed by TIA-1/TIAR Binding Downstream of the Nonconsensus Donor

Eun-Young Choi, David Pintel
Eun-Young Choi
Program in Genetics and Department of Molecular Microbiology and Immunology, University of Missouri—Columbia School of Medicine, Life Sciences Center, Columbia, Missouri 65211
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David Pintel
Program in Genetics and Department of Molecular Microbiology and Immunology, University of Missouri—Columbia School of Medicine, Life Sciences Center, Columbia, Missouri 65211
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  • For correspondence: pinteld@missouri.edu
DOI: 10.1128/JVI.00213-09
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Article Information

DOI 
https://doi.org/10.1128/JVI.00213-09
PubMed 
19339348

Published By 
American Society for Microbiology Journals
History 
  • Received January 29, 2009
  • Accepted March 24, 2009
  • Published online May 20, 2009.

Copyright & Usage 
Copyright © 2009 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (April 01, 2009).
  • You are viewing the most recent version of this article.

Author Information

  1. Eun-Young Choi† and
  2. David Pintel*
  1. Program in Genetics and Department of Molecular Microbiology and Immunology, University of Missouri—Columbia School of Medicine, Life Sciences Center, Columbia, Missouri 65211
  • ↵* Corresponding author. Mailing address: 471f Life Sciences Center, University of Missouri—Columbia, 1201 Rollins Rd., Columbia, MO 65211. Phone: (573) 882-3920. Fax: (573) 884-9676. E-mail: pinteld{at}missouri.edu
  • ↵† Present address: Gene Therapy Center, University of North Carolina—Chapel Hill, Chapel Hill, NC 27599-7352.

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Splicing of the Large Intron Present in the Nonstructural Gene of Minute Virus of Mice Is Governed by TIA-1/TIAR Binding Downstream of the Nonconsensus Donor
Eun-Young Choi, David Pintel
Journal of Virology May 2009, 83 (12) 6306-6311; DOI: 10.1128/JVI.00213-09

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Splicing of the Large Intron Present in the Nonstructural Gene of Minute Virus of Mice Is Governed by TIA-1/TIAR Binding Downstream of the Nonconsensus Donor
Eun-Young Choi, David Pintel
Journal of Virology May 2009, 83 (12) 6306-6311; DOI: 10.1128/JVI.00213-09
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  • Top
  • Article
    • ABSTRACT
    • U- and A-rich intronic sequences immediately downstream of the 5′ splice site of the large intron are required for its efficient excision.
    • The activity of the ISE is distance dependent.
    • TIA-1 and TIAR are important for the efficient use of the MVM nonconsensus large-intron donor.
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
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KEYWORDS

Enhancer Elements, Genetic
Introns
minute virus of mice
RNA splicing
RNA-binding proteins

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