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Pathogenesis and Immunity

Genital Ulcers Facilitate Rapid Viral Entry and Dissemination following Intravaginal Inoculation with Cell-Associated Simian Immunodeficiency Virus SIVmac239

Andrea M. Weiler, Qingsheng Li, Lijie Duan, Masahiko Kaizu, Kim L. Weisgrau, Thomas C. Friedrich, Matthew R. Reynolds, Ashley T. Haase, Eva G. Rakasz
Andrea M. Weiler
1AIDS Vaccine Research Laboratory, Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
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Qingsheng Li
2Department of Microbiology, University of Minnesota—Twin Cities, Minneapolis, Minnesota 55455
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Lijie Duan
2Department of Microbiology, University of Minnesota—Twin Cities, Minneapolis, Minnesota 55455
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Masahiko Kaizu
1AIDS Vaccine Research Laboratory, Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
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Kim L. Weisgrau
3Immunogenetics and Virology Unit, Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
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Thomas C. Friedrich
1AIDS Vaccine Research Laboratory, Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
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Matthew R. Reynolds
1AIDS Vaccine Research Laboratory, Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
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Ashley T. Haase
2Department of Microbiology, University of Minnesota—Twin Cities, Minneapolis, Minnesota 55455
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Eva G. Rakasz
1AIDS Vaccine Research Laboratory, Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
3Immunogenetics and Virology Unit, Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
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  • For correspondence: erakasz@primate.wisc.edu
DOI: 10.1128/JVI.01947-07
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Article Information

DOI 
https://doi.org/10.1128/JVI.01947-07
PubMed 
18272571

Published By 
American Society for Microbiology Journals
History 
  • Received September 5, 2007
  • Accepted February 5, 2008
  • Published online March 25, 2008.

Copyright & Usage 
Copyright © 2008 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (February 13, 2008).
  • You are viewing the most recent version of this article.

Author Information

  1. Andrea M. Weiler1†,
  2. Qingsheng Li2†,
  3. Lijie Duan2,
  4. Masahiko Kaizu1,
  5. Kim L. Weisgrau3,
  6. Thomas C. Friedrich1,
  7. Matthew R. Reynolds1,
  8. Ashley T. Haase2 and
  9. Eva G. Rakasz1,3*
  1. 1AIDS Vaccine Research Laboratory, Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
  2. 2Department of Microbiology, University of Minnesota—Twin Cities, Minneapolis, Minnesota 55455
  3. 3Immunogenetics and Virology Unit, Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
  • ↵† Andrea M. Weiler and Qingsheng Li contributed equally to this study.

  • ↵* Corresponding author. Mailing address: AIDS Vaccine Laboratory, WNPRC, 555 Science Dr., Madison, WI 53711. Phone: (608) 265-8998. Fax: (608) 265-8084. E-mail: erakasz{at}primate.wisc.edu
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Genital Ulcers Facilitate Rapid Viral Entry and Dissemination following Intravaginal Inoculation with Cell-Associated Simian Immunodeficiency Virus SIVmac239
Andrea M. Weiler, Qingsheng Li, Lijie Duan, Masahiko Kaizu, Kim L. Weisgrau, Thomas C. Friedrich, Matthew R. Reynolds, Ashley T. Haase, Eva G. Rakasz
Journal of Virology Mar 2008, 82 (8) 4154-4158; DOI: 10.1128/JVI.01947-07

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Genital Ulcers Facilitate Rapid Viral Entry and Dissemination following Intravaginal Inoculation with Cell-Associated Simian Immunodeficiency Virus SIVmac239
Andrea M. Weiler, Qingsheng Li, Lijie Duan, Masahiko Kaizu, Kim L. Weisgrau, Thomas C. Friedrich, Matthew R. Reynolds, Ashley T. Haase, Eva G. Rakasz
Journal of Virology Mar 2008, 82 (8) 4154-4158; DOI: 10.1128/JVI.01947-07
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  • Top
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    • ABSTRACT
    • Association of vRNA and vRNA+ cells with visible disruption of the mucosal barrier.
    • Rapid systemic dissemination of donor cells throughout lymphatic tissues.
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
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KEYWORDS

Female Urogenital Diseases
Simian Acquired Immunodeficiency Syndrome
simian immunodeficiency virus
Ulcer
Virus Internalization

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