Journal of Virology: 82 (7)

April 1, 2008; Volume 82,Issue 7

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Articles of Significant Interest Selected from This Issue by the Editors

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Human Immunodeficiency Virus Type 1 Vaccine Development: Recent Advances in the Cytotoxic T-Lymphocyte Platform “Spotty Business”
Kimberly A. Schoenly, David B. Weiner

Virus-Cell Interactions

Virus-Cell Interactions
NPXY Motifs in the β1 Integrin Cytoplasmic Tail Are Required for Functional Reovirus Entry
Melissa S. Maginnis, Bernardo A. Mainou, Aaron Derdowski, Elizabeth M. Johnson, Roy Zent, Terence S. Dermody
Virus-Cell Interactions
Identification of Hot Spots in the Variola Virus Complement Inhibitor (SPICE) for Human Complement Regulation
Viveka Nand Yadav, Kalyani Pyaram, Jayati Mullick, Arvind Sahu
Virus-Cell Interactions
Hepatitis C Virus Inhibits Cell Surface Expression of HLA-DR, Prevents Dendritic Cell Maturation, and Induces Interleukin-10 Production
Kousuke Saito, Malika Ait-Goughoulte, Steven M. Truscott, Keith Meyer, Azra Blazevic, Getahun Abate, Ratna B. Ray, Daniel F. Hoft, Ranjit Ray
Virus-Cell Interactions | Spotlight
Cellular Proteasome Activity Facilitates Herpes Simplex Virus Entry at a Postpenetration Step
Mark G. Delboy, Devin G. Roller, Anthony V. Nicola
Virus-Cell Interactions
Cell Cycle Association of the Retinoblastoma Protein Rb and the Histone Demethylase LSD1 with the Epstein-Barr Virus Latency Promoter Cp
Charles M. Chau, Zhong Deng, Hyojueng Kang, Paul M. Lieberman
Virus-Cell Interactions
The Human Cytomegalovirus Fc Receptor gp68 Binds the Fc C_H2-C_H3 Interface of Immunoglobulin G
Elizabeth R. Sprague, Henrike Reinhard, Evelyn J. Cheung, Alexander H. Farley, Robin Deis Trujillo, Hartmut Hengel, Pamela J. Bjorkman
Virus-Cell Interactions
The Tight Junction Proteins Claudin-1, -6, and -9 Are Entry Cofactors for Hepatitis C Virus
Laurent Meertens, Claire Bertaux, Lisa Cukierman, Emmanuel Cormier, Dimitri Lavillette, François-Loïc Cosset, Tatjana Dragic
Virus-Cell Interactions
Epstein-Barr Virus Lytic Transactivator Zta Enhances Chemotactic Activity through Induction of Interleukin-8 in Nasopharyngeal Carcinoma Cells
Meichi Hsu, Shih-Yi Wu, Shih-Shin Chang, Ih-Jen Su, Ching-Hwa Tsai, Siao-Jing Lai, Ai-Li Shiau, Kenzo Takada, Yao Chang
Virus-Cell Interactions
Functional Analysis of Picornavirus 2B Proteins: Effects on Calcium Homeostasis and Intracellular Protein Trafficking
Arjan S. de Jong, Fabrizio de Mattia, Michiel M. Van Dommelen, Kjerstin Lanke, Willem J. G. Melchers, Peter H. G. M. Willems, Frank J. M. van Kuppeveld
Virus-Cell Interactions
Early Phosphatidylinositol 3-Kinase/Akt Pathway Activation Limits Poliovirus-Induced JNK-Mediated Cell Death
Arnaud Autret, Sandra Martin-Latil, Cynthia Brisac, Laurence Mousson, Florence Colbère-Garapin, Bruno Blondel
Virus-Cell Interactions
E4Orf6-E1B-55k-Dependent Degradation of De Novo-Generated Adeno-Associated Virus Type 5 Rep52 and Capsid Proteins Employs a Cullin 5-Containing E3 Ligase Complex
Ramnath Nayak, K. David Farris, David J. Pintel

Structure and Assembly

Structure and Assembly
Three-Dimensional Structure of Canine Adenovirus Serotype 2 Capsid
Guy Schoehn, Majida El Bakkouri, Céline M. S. Fabry, Oliver Billet, Leandro F. Estrozi, Long Le, David T. Curiel, Andrey V. Kajava, Rob W. H. Ruigrok, Eric J. Kremer
Structure and Assembly
Functional Analysis of the Transmembrane (TM) Domain of the Autographa californica Multicapsid Nucleopolyhedrovirus GP64 Protein: Substitution of Heterologous TM Domains
Zhaofei Li, Gary W. Blissard
Structure and Assembly
Yellow Fever Virus NS3 Plays an Essential Role in Virus Assembly Independent of Its Known Enzymatic Functions
Chinmay G. Patkar, Richard J. Kuhn
Structure and Assembly
Electron Cryomicroscopy Reveals Different F1+F2 Protein States in Intact Parainfluenza Virions
Kai Ludwig, Boris Schade, Christoph Böttcher, Thomas Korte, Nina Ohlwein, Bolormaa Baljinnyam, Michael Veit, Andreas Herrmann

Genetic Diversity and Evolution

Genetic Diversity and Evolution
Full Genome-Based Classification of Rotaviruses Reveals a Common Origin between Human Wa-Like and Porcine Rotavirus Strains and Human DS-1-Like and Bovine Rotavirus Strains
Jelle Matthijnssens, Max Ciarlet, Erica Heiman, Ingrid Arijs, Thomas Delbeke, Sarah M. McDonald, Enzo A. Palombo, Miren Iturriza-Gómara, Piet Maes, John T. Patton, Mustafizur Rahman, Marc Van Ranst
Genetic Diversity and Evolution
Identification of the Progenitors of Indonesian and Vietnamese Avian Influenza A (H5N1) Viruses from Southern China
J. Wang, D. Vijaykrishna, L. Duan, J. Bahl, J. X. Zhang, R. G. Webster, J. S. M. Peiris, H. Chen, Gavin J. D. Smith, Y. Guan
Genetic Diversity and Evolution
Novel Mammalian Herpesviruses and Lineages within the Gammaherpesvirinae: Cospeciation and Interspecies Transfer
Bernhard Ehlers, Güzin Dural, Nezlisah Yasmum, Tiziana Lembo, Benoit de Thoisy, Marie-Pierre Ryser-Degiorgis, Rainer G. Ulrich, Duncan J. McGeoch
Genetic Diversity and Evolution | Spotlight
Rice Yellow Mottle Virus, an RNA Plant Virus, Evolves as Rapidly as Most RNA Animal Viruses
D. Fargette, A. Pinel, M. Rakotomalala, E. Sangu, O. Traoré, D. Sérémé, F. Sorho, S. Issaka, E. Hébrard, Y. Séré, Z. Kanyeka, G. Konaté
Genetic Diversity and Evolution
Genotype-Specific Genomic Markers Associated with Primary Hepatomas, Based on Complete Genomic Sequencing of Hepatitis B Virus
Joseph J. Y. Sung, Stephen K. W. Tsui, Chi-Hang Tse, Eddie Y. T. Ng, Kwong-Sak Leung, Kin-Hong Lee, Tony S. K. Mok, Angeline Bartholomeusz, Thomas C. C. Au, Kelvin K. F. Tsoi, Stephen Locarnini, Henry L. Y. Chan
Genetic Diversity and Evolution
Phylogenetic Evidence against Evolutionary Stasis and Natural Abiotic Reservoirs of Influenza A Virus
Michael Worobey

Pathogenesis and Immunity

Pathogenesis and Immunity
Structural Basis for Potent Cross-Neutralizing Human Monoclonal Antibody Protection against Lethal Human and Zoonotic Severe Acute Respiratory Syndrome Coronavirus Challenge
Barry Rockx, Davide Corti, Eric Donaldson, Timothy Sheahan, Konrad Stadler, Antonio Lanzavecchia, Ralph Baric
Pathogenesis and Immunity
Antiviral RNA Silencing Is Restricted to the Marginal Region of the Dark Green Tissue in the Mosaic Leaves of Tomato Mosaic Virus-Infected Tobacco Plants
Katsuyuki Hirai, Kenji Kubota, Tomofumi Mochizuki, Shinya Tsuda, Tetsuo Meshi
Pathogenesis and Immunity
Structural and Functional Dissection of the Human Cytomegalovirus Immune Evasion Protein US6
Gillian E. Dugan, Eric W. Hewitt
Pathogenesis and Immunity
Control of Virus-Specific CD8⁺ T-Cell Exhaustion and Immune-Mediated Pathology by E3 Ubiquitin Ligase Cbl-b during Chronic Viral Infection
Rong Ou, Menghua Zhang, Lei Huang, Demetrius Moskophidis
Pathogenesis and Immunity
Human HLA-DR Transgenes Protect Mice from Fatal Virus-Induced Encephalomyelitis and Chronic Demyelination
Moses Rodriguez, Laurie Zoecklein, Jason G. Kerkvliet, Kevin D. Pavelko, Louisa Papke, Charles L. Howe, Larry R. Pease, Chella David
Pathogenesis and Immunity
Emergence of Polyfunctional CD8⁺ T Cells after Prolonged Suppression of Human Immunodeficiency Virus Replication by Antiretroviral Therapy
Manuela Rehr, Julia Cahenzli, Anna Haas, David A. Price, Emma Gostick, Milo Huber, Urs Karrer, Annette Oxenius
Pathogenesis and Immunity
Analysis of the Evolutionary Forces in an Immunodominant CD8 Epitope in Hepatitis C Virus at a Population Level
Christoph Neumann-Haefelin, David N. Frick, Jing Jing Wang, Oliver G. Pybus, Shadi Salloum, Gagandeep S. Narula, Anna Eckart, Andrea Biezynski, Thomas Eiermann, Paul Klenerman, Sergei Viazov, Michael Roggendorf, Robert Thimme, Markus Reiser, Jörg Timm
Pathogenesis and Immunity | Spotlight
Scavenger Receptor Class B Is Required for Hepatitis C Virus Uptake and Cross-Presentation by Human Dendritic Cells
Heidi Barth, Eva K. Schnober, Christoph Neumann-Haefelin, Christine Thumann, Mirjam B. Zeisel, Helmut M. Diepolder, Zongyi Hu, T. Jake Liang, Hubert E. Blum, Robert Thimme, Mélanie Lambotin, Thomas F. Baumert
Pathogenesis and Immunity
Selective Ablation of Virion Host Shutoff Protein RNase Activity Attenuates Herpes Simplex Virus 2 in Mice
Maria Korom, Kristine M. Wylie, Lynda A. Morrison
Pathogenesis and Immunity
Evaluation of the Human Transmission Risk of an Atypical Bovine Spongiform Encephalopathy Prion Strain
Qingzhong Kong, Mengjie Zheng, Cristina Casalone, Liuting Qing, Shenghai Huang, Bikram Chakraborty, Ping Wang, Fusong Chen, Ignazio Cali, Cristiano Corona, Francesca Martucci, Barbara Iulini, Pierluigi Acutis, Lan Wang, Jingjing Liang, Meiling Wang, Xinyi Li, Salvatore Monaco, Gianluigi Zanusso, Wen-Quan Zou, Maria Caramelli, Pierluigi Gambetti
Pathogenesis and Immunity
Single-Cell, Phosphoepitope-Specific Analysis Demonstrates Cell Type- and Pathway-Specific Dysregulation of Jak/STAT and MAPK Signaling Associated with In Vivo Human Immunodeficiency Virus Type 1 Infection
Andrew W. Lee, Elizabeth R. Sharp, Alison O'Mahony, Michael G. Rosenberg, Dennis M. Israelski, Garry P. Nolan, Douglas F. Nixon
Pathogenesis and Immunity
Simian Immunodeficiency Virus SIVagm Dynamics in African Green Monkeys
Ivona Pandrea, Ruy M. Ribeiro, Rajeev Gautam, Thaidra Gaufin, Melissa Pattison, Mary Barnes, Christopher Monjure, Crystal Stoulig, Jason Dufour, Wayne Cyprian, Guido Silvestri, Michael D. Miller, Alan S. Perelson, Cristian Apetrei
Pathogenesis and Immunity | Spotlight
Short-Lived Infected Cells Support Virus Replication in Sooty Mangabeys Naturally Infected with Simian Immunodeficiency Virus: Implications for AIDS Pathogenesis
Shari N. Gordon, Richard M. Dunham, Jessica C. Engram, Jacob Estes, Zichun Wang, Nichole R. Klatt, Mirko Paiardini, Ivona V. Pandrea, Cristian Apetrei, Donald L. Sodora, Ha Youn Lee, Ashley T. Haase, Michael D. Miller, Amitinder Kaur, Silvija I. Staprans, Alan S. Perelson, Mark B. Feinberg, Guido Silvestri
Pathogenesis and Immunity
Immunomodulatory Properties of a Viral Homolog of Human Interleukin-10 Expressed by Human Cytomegalovirus during the Latent Phase of Infection
C. Jenkins, W. Garcia, M. J. Godwin, J. V. Spencer, J. Lewis Stern, A. Abendroth, B. Slobedman
Pathogenesis and Immunity
Alteration of B-Cell Subsets Enhances Neuroinvasion in Mouse Scrapie Infection
Christine von Poser-Klein, Eckhard Flechsig, Tanja Hoffmann, Petra Schwarz, Harry Harms, Raymond Bujdoso, Adriano Aguzzi, Michael A. Klein

Cellular Response to Infection

Cellular Response to Infection
The Fusion Protein of Respiratory Syncytial Virus Triggers p53-Dependent Apoptosis
Julia Eckardt-Michel, Markus Lorek, Diane Baxmann, Thomas Grunwald, Günther M. Keil, Gert Zimmer
Cellular Response to Infection | Spotlight
IRF-3 Activation by Sendai Virus Infection Is Required for Cellular Apoptosis and Avoidance of Persistence
Kristi Peters, Saurabh Chattopadhyay, Ganes C. Sen
Cellular Response to Infection
Influenza A Virus Strains Differ in Sensitivity to the Antiviral Action of Mx-GTPase
Jan Dittmann, Silke Stertz, Daniel Grimm, John Steel, Adolfo García-Sastre, Otto Haller, Georg Kochs

Vaccines and Antiviral Agents

Vaccines and Antiviral Agents
Amino Acid Mutation N348I in the Connection Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Multiclass Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors
Atsuko Hachiya, Eiichi N. Kodama, Stefan G. Sarafianos, Matthew M. Schuckmann, Yasuko Sakagami, Masao Matsuoka, Masafumi Takiguchi, Hiroyuki Gatanaga, Shinichi Oka
Vaccines and Antiviral Agents
Vaccination of BALB/c Mice with Escherichia coli-Expressed Vaccinia Virus Proteins A27L, B5R, and D8L Protects Mice from Lethal Vaccinia Virus Challenge
Aklile Berhanu, Rebecca L. Wilson, Dana L. Kirkwood-Watts, David S. King, Travis K. Warren, Susan A. Lund, Lindsay L. Brown, Alex K. Krupkin, Erin VanderMay, Will Weimers, Kady M. Honeychurch, Douglas W. Grosenbach, Kevin F. Jones, Dennis E. Hruby
Vaccines and Antiviral Agents
Efficient In Vitro Expansion of Human Immunodeficiency Virus (HIV)-Specific T-Cell Responses by gag mRNA-Electroporated Dendritic Cells from Treated and Untreated HIV Type 1-Infected Individuals
Ellen R. Van Gulck, Guido Vanham, Leo Heyndrickx, Sandra Coppens, Katleen Vereecken, Derek Atkinson, Eric Florence, Ilse Kint, Zwi Nisan Berneman, Viggo Van Tendeloo
Vaccines and Antiviral Agents
Redundancy and Plasticity of Neutralizing Antibody Responses Are Cornerstone Attributes of the Human Immune Response to the Smallpox Vaccine
Mohammed Rafii-El-Idrissi Benhnia, Megan M. McCausland, Hua-Poo Su, Kavita Singh, Julia Hoffmann, D. Huw Davies, Philip L. Felgner, Steven Head, Alessandro Sette, David N. Garboczi, Shane Crotty

Genome Replication and Regulation of Viral Gene Expression

Genome Replication and Regulation of Viral Gene Expression
Systematic Mutagenesis of the Murine Gammaherpesvirus 68 M2 Protein Identifies Domains Important for Chronic Infection
Jeremy H. Herskowitz, Andrea M. Siegel, Meagan A. Jacoby, Samuel H. Speck
Genome Replication and Regulation of Viral Gene Expression
Proteolytic Cleavage of VP1-2 Is Required for Release of Herpes Simplex Virus 1 DNA into the Nucleus
Vladimir Jovasevic, Li Liang, Bernard Roizman
Genome Replication and Regulation of Viral Gene Expression
Adenovirus E1B55K Region Is Required To Enhance Cyclin E Expression for Efficient Viral DNA Replication
Xinyu Zheng, Xiao-Mei Rao, Jorge G. Gomez-Gutierrez, Hongying Hao, Kelly M. McMasters, H. Sam Zhou
Genome Replication and Regulation of Viral Gene Expression
The Full-Length Protein Encoded by Human Cytomegalovirus Gene UL117 Is Required for the Proper Maturation of Viral Replication Compartments
Zhikang Qian, Baoqin Xuan, Te Tee Hong, Dong Yu
Genome Replication and Regulation of Viral Gene Expression
A Single-Amino-Acid Mutation in Hepatitis C Virus NS5A Disrupting FKBP8 Interaction Impairs Viral Replication
Toru Okamoto, Hiroko Omori, Yuuki Kaname, Takayuki Abe, Yorihiro Nishimura, Tetsuro Suzuki, Tatsuo Miyamura, Tamotsu Yoshimori, Kohji Moriishi, Yoshiharu Matsuura
Genome Replication and Regulation of Viral Gene Expression
Temporal Association of the Herpes Simplex Virus Genome with Histone Proteins during a Lytic Infection
Jaewook Oh, Nigel W. Fraser
Genome Replication and Regulation of Viral Gene Expression
Herpes Simplex Virus ICP27 Increases Translation of a Subset of Viral Late mRNAs
Errin C. Fontaine-Rodriguez, David M. Knipe
Genome Replication and Regulation of Viral Gene Expression
Stabilized Binding of TBP to the TATA Box of Herpes Simplex Virus Type 1 Early (tk) and Late (gC) Promoters by TFIIA and ICP4
Susan E. Zabierowski, Neal A. DeLuca
Genome Replication and Regulation of Viral Gene Expression
A Dormant Internal Ribosome Entry Site Controls Translation of Feline Immunodeficiency Virus
Valentina Camerini, Didier Decimo, Laurent Balvay, Mauro Pistello, Mauro Bendinelli, Jean-Luc Darlix, Théophile Ohlmann
Genome Replication and Regulation of Viral Gene Expression
Kaposi's Sarcoma-Associated Herpesvirus Transactivator RTA Promotes Degradation of the Repressors To Regulate Viral Lytic Replication
Zhilong Yang, Zhangcai Yan, Charles Wood
Genome Replication and Regulation of Viral Gene Expression
IRF-1 Is Required for Full NF-κB Transcriptional Activity at the Human Immunodeficiency Virus Type 1 Long Terminal Repeat Enhancer
Marco Sgarbanti, Anna L. Remoli, Giulia Marsili, Barbara Ridolfi, Alessandra Borsetti, Edvige Perrotti, Roberto Orsatti, Ramona Ilari, Leonardo Sernicola, Emilia Stellacci, Barbara Ensoli, Angela Battistini
Genome Replication and Regulation of Viral Gene Expression
Polypyrimidine Tract Binding Protein Induces Human Papillomavirus Type 16 Late Gene Expression by Interfering with Splicing Inhibitory Elements at the Major Late 5′ Splice Site, SD3632
Monika Somberg, Xiaomin Zhao, Monika Fröhlich, Magnus Evander, Stefan Schwartz
Genome Replication and Regulation of Viral Gene Expression
Rearrangements of Rotavirus Genomic Segment 11 Are Generated during Acute Infection of Immunocompetent Children and Do Not Occur at Random
Nathalie Schnepf, Claire Deback, Axelle Dehee, Elyanne Gault, Nathalie Parez, Antoine Garbarg-Chenon

Transformation and Oncogenesis

Transformation and Oncogenesis
Cdc55p-Mediated E4orf4 Growth Inhibition in Saccharomyces cerevisiae Is Mediated Only in Part via the Catalytic Subunit of Protein Phosphatase 2A
Yikun Li, Huijun Wei, Tung-Chin Hsieh, David C. Pallas
Transformation and Oncogenesis
Epstein-Barr Virus-Encoded LMP1 Regulates Epithelial Cell Motility and Invasion via the ERK-MAPK Pathway
Christopher W. Dawson, Louise Laverick, Mhairi A. Morris, Giorgos Tramoutanis, Lawrence S. Young

Letters to the Editor

Letter to the Editor
Human Adenovirus Type 52: a Type 41 in Disguise?
J. C. de Jong, A. D. M. E. Osterhaus

Author's Correction

AUTHOR'S CORRECTION
Influenza Virus Infection Causes Specific Degradation of the Largest Subunit of Cellular RNA Polymerase II
A. Rodriguez, A. Pérez-González, A. Nieto

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Table of Contents

Spotlight

Minireviews

Virus-Cell Interactions

Structure and Assembly

Genetic Diversity and Evolution

Pathogenesis and Immunity

Cellular Response to Infection

Vaccines and Antiviral Agents

Genome Replication and Regulation of Viral Gene Expression

Transformation and Oncogenesis

Letters to the Editor

Author's Correction

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