Journal of Virology: 82 (6)

March 15, 2008; Volume 82,Issue 6

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Articles of Significant Interest Selected from This Issue by the Editors

Cellular Response to Infection

Cellular Response to Infection
Hepatitis C Virus Core Protein Upregulates Serine Phosphorylation of Insulin Receptor Substrate-1 and Impairs the Downstream Akt/Protein Kinase B Signaling Pathway for Insulin Resistance
Sutapa Banerjee, Kousuke Saito, Malika Ait-Goughoulte, Keith Meyer, Ratna B. Ray, Ranjit Ray
Cellular Response to Infection
The DNA Deaminase Activity of Human APOBEC3G Is Required for Ty1, MusD, and Human Immunodeficiency Virus Type 1 Restriction
April J. Schumacher, Guylaine Haché, Donna A. MacDuff, William L. Brown, Reuben S. Harris
Cellular Response to Infection | Spotlight
Clonogenic Assay of Type A Influenza Viruses Reveals Noninfectious Cell-Killing (Apoptosis-Inducing) Particles
John M. Ngunjiri, Margaret J. Sekellick, Philip I. Marcus
Cellular Response to Infection
Complement Is an Essential Component of the Immune Response to Adeno-Associated Virus Vectors
Anne K. Zaiss, Matthew J. Cotter, Lindsay R. White, Sharon A. Clark, Norman C. W. Wong, V. Michael Holers, Jeffrey S. Bartlett, Daniel A. Muruve
Cellular Response to Infection
Avian Influenza Virus A/HK/483/97(H5N1) NS1 Protein Induces Apoptosis in Human Airway Epithelial Cells
W. Y. Lam, Julian W. Tang, Apple C. M. Yeung, Lawrence C. M. Chiu, Joseph J. Y. Sung, Paul K. S. Chan
Cellular Response to Infection | Spotlight
Phagocytosis of Picornavirus-Infected Cells Induces an RNA-Dependent Antiviral State in Human Dendritic Cells
Matthijs Kramer, Barbara M. Schulte, Liza W. J. Toonen, Paola M. Barral, Paul B. Fisher, Kjerstin H. W. Lanke, Jochem M. D. Galama, Frank J. M. van Kuppeveld, Gosse J. Adema

Virus-Cell Interactions

Virus-Cell Interactions
Characterization of Hypovirus-Derived Small RNAs Generated in the Chestnut Blight Fungus by an Inducible DCL-2-Dependent Pathway
Xuemin Zhang, Gert C. Segers, Qihong Sun, Fuyou Deng, Donald L. Nuss
Virus-Cell Interactions
Replication of ICP0-Null Mutant Herpes Simplex Virus Type 1 Is Restricted by both PML and Sp100
Roger D. Everett, Carlos Parada, Philippe Gripon, Hüseyin Sirma, Anne Orr
Virus-Cell Interactions
Mitochondrial and Secretory Human Cytomegalovirus UL37 Proteins Traffic into Mitochondrion-Associated Membranes of Human Cells
Petros Bozidis, Chad D. Williamson, Anamaris M. Colberg-Poley
Virus-Cell Interactions
The Spike Protein of Infectious Bronchitis Virus Is Retained Intracellularly by a Tyrosine Motif
Christine Winter, Christel Schwegmann-Wessels, Ulrich Neumann, Georg Herrler
Virus-Cell Interactions
Class VIII Myosins Are Required for Plasmodesmatal Localization of a Closterovirus Hsp70 Homolog
Dror Avisar, Alexey I. Prokhnevsky, Valerian V. Dolja
Virus-Cell Interactions
Aromatic Amino Acids in the Juxtamembrane Domain of Severe Acute Respiratory Syndrome Coronavirus Spike Glycoprotein Are Important for Receptor-Dependent Virus Entry and Cell-Cell Fusion
Megan W. Howard, Emily A. Travanty, Scott A. Jeffers, M. K. Smith, Sonia T. Wennier, Larissa B. Thackray, Kathryn V. Holmes
Virus-Cell Interactions
Human Immunodeficiency Virus Type 1 Vpr Induces Cell Cycle G₂ Arrest through Srk1/MK2-Mediated Phosphorylation of Cdc25
Sylvain Huard, Robert T. Elder, Dong Liang, Ge Li, Richard Y. Zhao
Virus-Cell Interactions
Human Immunodeficiency Virus Type 1 Nef Recruits the Guanine Exchange Factor Vav1 via an Unexpected Interface into Plasma Membrane Microdomains for Association with p21-Activated Kinase 2 Activity
Susanne Rauch, Kati Pulkkinen, Kalle Saksela, Oliver T. Fackler
Virus-Cell Interactions
Sialic Acid Is a Cellular Receptor for Coxsackievirus A24 Variant, an Emerging Virus with Pandemic Potential
Emma C. Nilsson, Fariba Jamshidi, Susanne M. C. Johansson, M. Steven Oberste, Niklas Arnberg
Virus-Cell Interactions
Cellular Restriction of Retrovirus Particle-Mediated mRNA Transfer
Melanie Galla, Axel Schambach, Greg J. Towers, Christopher Baum
Virus-Cell Interactions
Role of APOBEC3G/F-Mediated Hypermutation in the Control of Human Immunodeficiency Virus Type 1 in Elite Suppressors
Shiv K. Gandhi, Janet D. Siliciano, Justin R. Bailey, Robert F. Siliciano, Joel N. Blankson

Pathogenesis and Immunity

Pathogenesis and Immunity
Alpha/Beta Interferon Inhibits Cap-Dependent Translation of Viral but Not Cellular mRNA by a PKR-Independent Mechanism
Mulu Z. Tesfay, Jun Yin, Christina L. Gardner, Mikhail V. Khoretonenko, Nadejda L. Korneeva, Robert E. Rhoads, Kate D. Ryman, William B. Klimstra
Pathogenesis and Immunity
Rift Valley Fever Virus Lacking the NSs and NSm Genes Is Highly Attenuated, Confers Protective Immunity from Virulent Virus Challenge, and Allows for Differential Identification of Infected and Vaccinated Animals
Brian H. Bird, César G. Albariño, Amy L. Hartman, Bobbie Rae Erickson, Thomas G. Ksiazek, Stuart T. Nichol
Pathogenesis and Immunity
Inhibition of IRF-3 Activation by VP35 Is Critical for the High Level of Virulence of Ebola Virus
Amy L. Hartman, Brian H. Bird, Jonathan S. Towner, Zoi-Anna Antoniadou, Sherif R. Zaki, Stuart T. Nichol
Pathogenesis and Immunity
Neutrophils Play an Essential Role in Cooperation with Antibody in both Protection against and Recovery from Pulmonary Infection with Influenza Virus in Mice
Haruo Fujisawa
Pathogenesis and Immunity
Active β-Catenin Signaling Is an Inhibitory Pathway for Human Immunodeficiency Virus Replication in Peripheral Blood Mononuclear Cells
Anvita Kumar, Andrew Zloza, Randall T. Moon, Jeffrey Watts, Allan R. Tenorio, Lena Al-Harthi
Pathogenesis and Immunity
Magnitude, Breadth, and Functional Profile of T-Cell Responses during Human Immunodeficiency Virus Primary Infection with B and BF Viral Variants
Gabriela Turk, María Magdalena Gherardi, Natalia Laufer, Mónica Saracco, Renata Luzzi, Josephine H. Cox, Pedro Cahn, Horacio Salomon
Pathogenesis and Immunity
Regulation of Immune Response and Inflammatory Reactions against Viral Infection by VCAM-1
Rong Ou, Menghua Zhang, Lei Huang, Richard A. Flavell, Pandelakis A. Koni, Demetrius Moskophidis
Pathogenesis and Immunity
Evidence for Differential Roles for NKG2D Receptor Signaling in Innate Host Defense against Coronavirus-Induced Neurological and Liver Disease
Kevin B. Walsh, Melissa B. Lodoen, Robert A. Edwards, Lewis L. Lanier, Thomas E. Lane
Pathogenesis and Immunity
NKG2D Receptor Signaling Enhances Cytolytic Activity by Virus-Specific CD8⁺ T Cells: Evidence for a Protective Role in Virus-Induced Encephalitis
Kevin B. Walsh, Lewis L. Lanier, Thomas E. Lane
Pathogenesis and Immunity
Virus-Specific T-Cell Immunity Correlates with Control of GB Virus B Infection in Marmosets
David J. Woollard, Gholamreza Haqshenas, Xuebin Dong, Bridget F. Pratt, Stephen J. Kent, Eric J. Gowans
Pathogenesis and Immunity
Antiviral CD8 T Cells Recognize Borna Disease Virus Antigen Transgenically Expressed in either Neurons or Astrocytes
Karen Baur, Mathias Rauer, Kirsten Richter, Axel Pagenstecher, Jürgen Götz, Jürgen Hausmann, Peter Staeheli
Pathogenesis and Immunity
Differential Requirements for T Cells in Viruslike Particle- and Rotavirus-Induced Protective Immunity
Sarah E. Blutt, Kelly L. Warfield, Mary K. Estes, Margaret E. Conner
Pathogenesis and Immunity
Selective Downregulation of Rhesus Macaque and Sooty Mangabey Major Histocompatibility Complex Class I Molecules by Nef Alleles of Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2
M. Quinn DeGottardi, Anke Specht, Benjamin Metcalf, Amitinder Kaur, Frank Kirchhoff, David T. Evans
Pathogenesis and Immunity
Increased Cytotoxic T-Lymphocyte Epitope Variant Cross-Recognition and Functional Avidity Are Associated with Hepatitis C Virus Clearance
Daniel Yerly, David Heckerman, Todd M. Allen, John V. Chisholm, Kellie Faircloth, Caitlyn H. Linde, Nicole Frahm, Joerg Timm, Werner J. Pichler, Andreas Cerny, Christian Brander
Pathogenesis and Immunity
High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8⁺ and CD4⁺ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome
Victoria Kasprowicz, Julian Schulze zur Wiesch, Thomas Kuntzen, Brian E. Nolan, Steven Longworth, Andrew Berical, Jenna Blum, Cory McMahon, Laura L. Reyor, Nahel Elias, William W. Kwok, Barbara G. McGovern, Gordon Freeman, Raymond T. Chung, Paul Klenerman, Lia Lewis-Ximenez, Bruce D. Walker, Todd M. Allen, Arthur Y. Kim, Georg M. Lauer

Genome Replication and Regulation of Viral Gene Expression

Genome Replication and Regulation of Viral Gene Expression
Human Butyrate-Induced Transcript 1 Interacts with Hepatitis C Virus NS5A and Regulates Viral Replication
Shuhei Taguwa, Toru Okamoto, Takayuki Abe, Yoshio Mori, Tetsuro Suzuki, Kohji Moriishi, Yoshiharu Matsuura
Genome Replication and Regulation of Viral Gene Expression
Control of mRNA Export by Adenovirus E4orf6 and E1B55K Proteins during Productive Infection Requires E4orf6 Ubiquitin Ligase Activity
Paola Blanchette, Kathrin Kindsmüller, Peter Groitl, Frédéric Dallaire, Thomas Speiseder, Philip E. Branton, Thomas Dobner
Genome Replication and Regulation of Viral Gene Expression
Kaposi's Sarcoma-Associated Herpesvirus ORF57 Functions as a Viral Splicing Factor and Promotes Expression of Intron-Containing Viral Lytic Genes in Spliceosome-Mediated RNA Splicing
Vladimir Majerciak, Koji Yamanegi, Eric Allemand, Michael Kruhlak, Adrian R. Krainer, Zhi-Ming Zheng
Genome Replication and Regulation of Viral Gene Expression
Kaposi's Sarcoma-Associated Herpesvirus ori-Lyt-Dependent DNA Replication: Involvement of Host Cellular Factors
Yan Wang, Hong Li, Qiyi Tang, Gerd G. Maul, Yan Yuan
Genome Replication and Regulation of Viral Gene Expression
cis- and trans-Acting Functions of Brome Mosaic Virus Protein 1a in Genomic RNA1 Replication
Guanghui Yi, Cheng Kao
Genome Replication and Regulation of Viral Gene Expression
RNA Structure Modulates Splicing Efficiency at the Human Immunodeficiency Virus Type 1 Major Splice Donor
Truus E. M. Abbink, Ben Berkhout

Vaccines and Antiviral Agents

Vaccines and Antiviral Agents
Expression of Transgenes from Newcastle Disease Virus with a Segmented Genome
Qinshan Gao, Man-Seong Park, Peter Palese
Vaccines and Antiviral Agents | Spotlight
Primary Human Immunodeficiency Virus Type 1 (HIV-1) Infection during HIV-1 Gag Vaccination
Arumugam Balamurugan, Martha J. Lewis, Christina M. R. Kitchen, Michael N. Robertson, John W. Shiver, Eric S. Daar, Jacqueline Pitt, Ayub Ali, Hwee L. Ng, Judith S. Currier, Otto O. Yang
Vaccines and Antiviral Agents
Human Immunodeficiency Virus Type 1 Escape Is Restricted When Conserved Genome Sequences Are Targeted by RNA Interference
Karin Jasmijn von Eije, Olivier ter Brake, Ben Berkhout
Vaccines and Antiviral Agents
Targets of Small Interfering RNA Restriction during Human Immunodeficiency Virus Type 1 Replication
Yong Gao, Michael A. Lobritz, Justin Roth, Measho Abreha, Kenneth N. Nelson, Immaculate Nankya, Dawn M. Moore-Dudley, Awet Abraha, Stanton L. Gerson, Eric J. Arts
Vaccines and Antiviral Agents
Differential CD4⁺ versus CD8⁺ T-Cell Responses Elicited by Different Poxvirus-Based Human Immunodeficiency Virus Type 1 Vaccine Candidates Provide Comparable Efficacies in Primates
Petra Mooij, Sunita S. Balla-Jhagjhoorsingh, Gerrit Koopman, Niels Beenhakker, Patricia van Haaften, Ilona Baak, Ivonne G. Nieuwenhuis, Ivanela Kondova, Ralf Wagner, Hans Wolf, Carmen E. Gómez, José L. Nájera, Victoria Jiménez, Mariano Esteban, Jonathan L. Heeney

Transformation and Oncogenesis

Transformation and Oncogenesis
BK Virus as a Cofactor in the Etiology of Prostate Cancer in Its Early Stages
Dweepanita Das, Kirk Wojno, Michael J. Imperiale

Structure and Assembly

Structure and Assembly
Molecular Characterization of a Subgroup Specificity Associated with the Rotavirus Inner Capsid Protein VP2
Sarah M. McDonald, John T. Patton
Structure and Assembly
UL74 of Human Cytomegalovirus Contributes to Virus Release by Promoting Secondary Envelopment of Virions
Xiao Jing Jiang, Barbara Adler, Kerstin Laib Sampaio, Margarete Digel, Gerhard Jahn, Nicole Ettischer, York-Dieter Stierhof, Laura Scrivano, Ulrich Koszinowski, Michael Mach, Christian Sinzger
Structure and Assembly | Spotlight
Egress of Light Particles among Filopodia on the Surface of Varicella-Zoster Virus-Infected Cells
John E. Carpenter, Jennifer A. Hutchinson, Wallen Jackson, Charles Grose
Structure and Assembly
Geometric Mismatches within the Concentric Layers of Rotavirus Particles: a Potential Regulatory Switch of Viral Particle Transcription Activity
Sonia Libersou, Xavier Siebert, Malika Ouldali, Leandro F. Estrozi, Jorge Navaza, Annie Charpilienne, Pascale Garnier, Didier Poncet, Jean Lepault
Structure and Assembly
Genetic Determinants of Sindbis Virus Mosquito Infection Are Associated with a Highly Conserved Alphavirus and Flavivirus Envelope Sequence
Dennis J. Pierro, Erik L. Powers, Ken E. Olson
Structure and Assembly | Spotlight
Envelope Protein Palmitoylations Are Crucial for Murine Coronavirus Assembly
Joseph A. Boscarino, Hillary L. Logan, Jason J. Lacny, Thomas M. Gallagher
Structure and Assembly | Spotlight
Importance of Conserved Cysteine Residues in the Coronavirus Envelope Protein
Lisa A. Lopez, Ambere J. Riffle, Steven L. Pike, Douglas Gardner, Brenda G. Hogue
Structure and Assembly
Crystal Structure of Unliganded Influenza B Virus Hemagglutinin
Qinghua Wang, Feng Cheng, Mingyang Lu, Xia Tian, Jianpeng Ma
Structure and Assembly
Nuclear Egress and Envelopment of Herpes Simplex Virus Capsids Analyzed with Dual-Color Fluorescence HSV1(17⁺)
Claus-Henning Nagel, Katinka Döhner, Mojgan Fathollahy, Tanja Strive, Eva Maria Borst, Martin Messerle, Beate Sodeik
Structure and Assembly
Cysteines Flanking the Internal Fusion Peptide Are Required for the Avian Sarcoma/Leukosis Virus Glycoprotein To Mediate the Lipid Mixing Stage of Fusion with High Efficiency
Sue E. Delos, Matthew B. Brecher, Zaoying Chen, Deborah C. Melder, Mark J. Federspiel, Judith M. White

Gene Delivery

Gene Delivery
Lentiviral Vectors Encoding Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Receptor Genes Efficiently Convert Peripheral Blood CD8 T Lymphocytes into Cytotoxic T Lymphocytes with Potent In Vitro and In Vivo HIV-1-Specific Inhibitory Activity
Aviva Joseph, Jian Hua Zheng, Antonia Follenzi, Teresa DiLorenzo, Kaori Sango, Jaime Hyman, Ken Chen, Alicja Piechocka-Trocha, Christian Brander, Erik Hooijberg, Dario A. Vignali, Bruce D. Walker, Harris Goldstein

Errata

Erratum
Compensatory Mutation Partially Restores Fitness and Delays Reversion of Escape Mutation within the Immunodominant HLA-B*5703-Restricted Gag Epitope in Chronic Human Immunodeficiency Virus Type 1 Infection
Hayley Crawford, Julia G. Prado, Alasdair Leslie, Stéphane Hué, Isobella Honeyborne, Sharon Reddy, Mary van der Stok, Zenele Mncube, Christian Brander, Christine Rousseau, James I. Mullins, Richard Kaslow, Paul Goepfert, Susan Allen, Eric Hunter, Joseph Mulenga, Photini Kiepiela, Bruce D. Walker, Philip J. R. Goulder

Author's Correction

AUTHOR'S CORRECTION
Epstein-Barr Virus BGLF4 Kinase Induces Premature Chromosome Condensation through Activation of Condensin and Topoisomerase II
Chung-Pei Lee, Jen-Yang Chen, Jiin-Tarng Wang, Keiji Kimura, Ai Takemoto, Chih-Chung Lu, Mei-Ru Chen
AUTHOR'S CORRECTION
Ebola Virus VP24 Proteins Inhibit the Interaction of NPI-1 Subfamily Karyopherin α Proteins with Activated STAT1
St. Patrick Reid, Charalampos Valmas, Osvaldo Martinez, Freddy Mauricio Sanchez, Christopher F. Basler

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Table of Contents

Spotlight

Cellular Response to Infection

Virus-Cell Interactions

Pathogenesis and Immunity

Genome Replication and Regulation of Viral Gene Expression

Vaccines and Antiviral Agents

Transformation and Oncogenesis

Structure and Assembly

Gene Delivery

Errata

Author's Correction

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