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Gene Delivery

Multiple Displacement Amplification Enables Large-Scale Clonal Analysis following Retroviral Gene Therapy

S. Bleier, P. Maier, H. Allgayer, F. Wenz, W. J. Zeller, S. Fruehauf, S. Laufs
S. Bleier
1Research Program Innovative Cancer Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany
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P. Maier
2Department of Radiation Oncology, Mannheim Medical Center, University of Heidelberg, Heidelberg, Germany
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H. Allgayer
3Department of Experimental Surgery and Molecular Oncology of Solid Tumors, Medical Faculty Mannheim, University of Heidelberg, and German Cancer Research Center (DKFZ) Heidelberg, Mannheim, Germany
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F. Wenz
2Department of Radiation Oncology, Mannheim Medical Center, University of Heidelberg, Heidelberg, Germany
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W. J. Zeller
1Research Program Innovative Cancer Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany
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S. Fruehauf
4Center for Tumor Diagnostics and Therapy, Paracelsus Klinik, Osnabrueck, Germany
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S. Laufs
3Department of Experimental Surgery and Molecular Oncology of Solid Tumors, Medical Faculty Mannheim, University of Heidelberg, and German Cancer Research Center (DKFZ) Heidelberg, Mannheim, Germany
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  • For correspondence: s.laufs@dkfz.de
DOI: 10.1128/JVI.00584-07
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Article Information

DOI 
https://doi.org/10.1128/JVI.00584-07
PubMed 
18077708

Published By 
American Society for Microbiology Journals
History 
  • Received March 20, 2007
  • Accepted December 13, 2007
  • Published online February 11, 2008.

Copyright & Usage 
Copyright © 2008 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (December 12, 2007).
  • You are viewing the most recent version of this article.

Author Information

  1. S. Bleier1†,
  2. P. Maier2†,
  3. H. Allgayer3,
  4. F. Wenz2,
  5. W. J. Zeller1,
  6. S. Fruehauf4 and
  7. S. Laufs3*
  1. 1Research Program Innovative Cancer Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany
  2. 2Department of Radiation Oncology, Mannheim Medical Center, University of Heidelberg, Heidelberg, Germany
  3. 3Department of Experimental Surgery and Molecular Oncology of Solid Tumors, Medical Faculty Mannheim, University of Heidelberg, and German Cancer Research Center (DKFZ) Heidelberg, Mannheim, Germany
  4. 4Center for Tumor Diagnostics and Therapy, Paracelsus Klinik, Osnabrueck, Germany
  • ↵† These authors contributed equally to this work.

  • ↵* Corresponding author. Mailing address: Molecular Oncology of Solid Tumors, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany. Phone: 49-6221-421710. Fax: 49-6221-421719. E-mail: s.laufs{at}dkfz.de

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Multiple Displacement Amplification Enables Large-Scale Clonal Analysis following Retroviral Gene Therapy
S. Bleier, P. Maier, H. Allgayer, F. Wenz, W. J. Zeller, S. Fruehauf, S. Laufs
Journal of Virology Feb 2008, 82 (5) 2448-2455; DOI: 10.1128/JVI.00584-07

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Multiple Displacement Amplification Enables Large-Scale Clonal Analysis following Retroviral Gene Therapy
S. Bleier, P. Maier, H. Allgayer, F. Wenz, W. J. Zeller, S. Fruehauf, S. Laufs
Journal of Virology Feb 2008, 82 (5) 2448-2455; DOI: 10.1128/JVI.00584-07
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KEYWORDS

Gene Amplification
Genetic Therapy
Retroviridae

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