Journal of Virology: 82 (20)

October 15, 2008; Volume 82,Issue 20

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Articles of Significant Interest Selected from This Issue by the Editors

Pathogenesis and Immunity

Pathogenesis and Immunity
Impaired Hepatitis C Virus (HCV)-Specific Effector CD8⁺ T Cells Undergo Massive Apoptosis in the Peripheral Blood during Acute HCV Infection and in the Liver during the Chronic Phase of Infection
Henry Radziewicz, Chris C. Ibegbu, Huiming Hon, Melissa K. Osborn, Kamil Obideen, Mohammad Wehbi, Gordon J. Freeman, Jeffrey L. Lennox, Kimberly A. Workowski, Holly L. Hanson, Arash Grakoui
Pathogenesis and Immunity
Murine Coronavirus Mouse Hepatitis Virus Is Recognized by MDA5 and Induces Type I Interferon in Brain Macrophages/Microglia
Jessica K. Roth-Cross, Susan J. Bender, Susan R. Weiss
Pathogenesis and Immunity
Lymphoid-Related CD11c⁺ CD8α⁺ Dendritic Cells Are Involved in Enhancing Herpes Simplex Virus Type 1 Latency
Kevin R. Mott, David UnderHill, Steven L. Wechsler, Homayon Ghiasi
Pathogenesis and Immunity
CD20, CD3, and CD40 Ligand Microclusters Segregate Three-Dimensionally In Vivo at B-Cell-T-Cell Immunological Synapses after Viral Immunity in Primate Brain
Carlos Barcia, Aurora Gomez, Vicente de Pablos, Emiliano Fernández-Villalba, Chunyan Liu, Kurt M. Kroeger, Javier Martín, Andrés Fernández Barreiro, Maria G. Castro, Pedro R. Lowenstein, Maria-Trinidad Herrero
Pathogenesis and Immunity
Neonatal Neural Progenitor Cells and Their Neuronal and Glial Cell Derivatives Are Fully Permissive for Human Cytomegalovirus Infection
Min Hua Luo, Philip H. Schwartz, Elizabeth A. Fortunato
Pathogenesis and Immunity
Early Interferon Therapy for Hepatitis C Virus Infection Rescues Polyfunctional, Long-Lived CD8⁺ Memory T Cells
Gamal Badr, Nathalie Bédard, Mohamed S. Abdel-Hakeem, Lydie Trautmann, Bernard Willems, Jean-Pierre Villeneuve, Elias K. Haddad, Rafick P. Sékaly, Julie Bruneau, Naglaa H. Shoukry
Pathogenesis and Immunity
Oseltamivir-Resistant Influenza A Viruses Are Transmitted Efficiently among Guinea Pigs by Direct Contact but Not by Aerosol
Nicole M. Bouvier, Anice C. Lowen, Peter Palese
Pathogenesis and Immunity
Vaccinia Virus Encodes I5, a Small Hydrophobic Virion Membrane Protein That Enhances Replication and Virulence in Mice
Cindy L. Sood, Jerrold M. Ward, Bernard Moss
Pathogenesis and Immunity
Expansion of Human Cytomegalovirus (HCMV) Immediate-Early 1-Specific CD8⁺ T Cells and Control of HCMV Replication after Allogeneic Stem Cell Transplantation
Karim Sacre, Stéphanie Nguyen, Claire Deback, Guislaine Carcelain, Jean-Paul Vernant, Véronique Leblond, Brigitte Autran, Nathalie Dhedin
Pathogenesis and Immunity
Functions of Varicella-Zoster Virus ORF23 Capsid Protein in Viral Replication and the Pathogenesis of Skin Infection
Vaishali Chaudhuri, Marvin Sommer, Jaya Rajamani, Leigh Zerboni, Ann M. Arvin
Pathogenesis and Immunity
The Quality of Chimpanzee T-Cell Activation and Simian Immunodeficiency Virus/Human Immunodeficiency Virus Susceptibility Achieved via Antibody-Mediated T-Cell Receptor/CD3 Stimulation Is a Function of the Anti-CD3 Antibody Isotype
Frederic Bibollet-Ruche, Brett A. McKinney, Alexandra Duverger, Frederic H. Wagner, Aftab A. Ansari, Olaf Kutsch
Pathogenesis and Immunity
Regulatory Role of CD1d in Neurotropic Virus Infection
Ikuo Tsunoda, Tomoko Tanaka, Robert S. Fujinami
Pathogenesis and Immunity
Herpes Simplex Virus Type 2-Induced Mortality following Genital Infection Is Blocked by Anti-Tumor Necrosis Factor Alpha Antibody in CXCL10-Deficient Mice
Manoj Thapa, Daniel J. J. Carr
Pathogenesis and Immunity
In Vivo Competence of Murine Cytomegalovirus under the Control of the Human Cytomegalovirus Major Immediate-Early Enhancer in the Establishment of Latency and Reactivation
Montse Gustems, Andreas Busche, Martin Messerle, Peter Ghazal, Ana Angulo
Pathogenesis and Immunity
Fusion of Enhanced Green Fluorescent Protein to the Pseudorabies Virus Axonal Sorting Protein Us9 Blocks Anterograde Spread of Infection in Mammalian Neurons
M. G. Lyman, D. Curanovic, A. D. Brideau, L. W. Enquist
Pathogenesis and Immunity
Scrapie Resistance in ARQ Sheep
W. W. Laegreid, M. L. Clawson, M. P. Heaton, B. T. Green, K. I. O'Rourke, D. P. Knowles

Genome Replication and Regulation of Viral Gene Expression

Genome Replication and Regulation of Viral Gene Expression
Evolutionarily Conserved Function of a Viral MicroRNA
G. J. Seo, L. H. L. Fink, B. O'Hara, W. J. Atwood, C. S. Sullivan
Genome Replication and Regulation of Viral Gene Expression
NF-κB Signaling Differentially Regulates Influenza Virus RNA Synthesis
Naveen Kumar, Zhong-tao Xin, Yuhong Liang, Hinh Ly, Yuying Liang
Genome Replication and Regulation of Viral Gene Expression
Transactivation of Cellular Genes Involved in Nucleotide Metabolism by the Regulatory IE1 Protein of Murine Cytomegalovirus Is Not Critical for Viral Replicative Fitness in Quiescent Cells and Host Tissues
Vanessa Wilhelmi, Christian O. Simon, Jürgen Podlech, Verena Böhm, Torsten Däubner, Simone Emde, Dennis Strand, Angélique Renzaho, Niels A. W. Lemmermann, Christof K. Seckert, Matthias J. Reddehase, Natascha K. A. Grzimek
Genome Replication and Regulation of Viral Gene Expression
Block to the Production of Full-Length B19 Virus Transcripts by Internal Polyadenylation Is Overcome by Replication of the Viral Genome
Wuxiang Guan, Fang Cheng, Yuko Yoto, Steve Kleiboeker, Susan Wong, Ning Zhi, David J. Pintel, Jianming Qiu
Genome Replication and Regulation of Viral Gene Expression
Integration Site Preference of Xenotropic Murine Leukemia Virus-Related Virus, a New Human Retrovirus Associated with Prostate Cancer
Sanggu Kim, Namshin Kim, Beihua Dong, David Boren, Serena A. Lee, Jaydip Das Gupta, Christina Gaughan, Eric A. Klein, Christopher Lee, Robert H. Silverman, Samson A. Chow
Genome Replication and Regulation of Viral Gene Expression
Human Endogenous Retrovirus Family HERV-K(HML-2) RNA Transcripts Are Selectively Packaged into Retroviral Particles Produced by the Human Germ Cell Tumor Line Tera-1 and Originate Mainly from a Provirus on Chromosome 22q11.21
Klemens Ruprecht, Humberto Ferreira, Aline Flockerzi, Silke Wahl, Marlies Sauter, Jens Mayer, Nikolaus Mueller-Lantzsch
Genome Replication and Regulation of Viral Gene Expression
Different Types of nsP3-Containing Protein Complexes in Sindbis Virus-Infected Cells
Rodion Gorchakov, Natalia Garmashova, Elena Frolova, Ilya Frolov
Genome Replication and Regulation of Viral Gene Expression
Identification of a Conserved RNA Replication Element (cre) within the 3D^pol-Coding Sequence of Hepatoviruses
Yan Yang, MinKyung Yi, David J. Evans, Peter Simmonds, Stanley M. Lemon
Genome Replication and Regulation of Viral Gene Expression
A Viral Noncoding RNA Generated by cis-Element-Mediated Protection against 5′→3′ RNA Decay Represses both Cap-Independent and Cap-Dependent Translation
Hiro-oki Iwakawa, Hiroyuki Mizumoto, Hideaki Nagano, Yuka Imoto, Kazuma Takigawa, Siriruk Sarawaneeyaruk, Masanori Kaido, Kazuyuki Mise, Tetsuro Okuno
Genome Replication and Regulation of Viral Gene Expression
Mutational Evidence for a Structural Model of the Lassa Virus RNA Polymerase Domain and Identification of Two Residues, Gly1394 and Asp1395, That Are Critical for Transcription but Not Replication of the Genome
Meike Hass, Michaela Lelke, Carola Busch, Beate Becker-Ziaja, Stephan Günther
Genome Replication and Regulation of Viral Gene Expression
Monomeric Linear RNA of Citrus Exocortis Viroid Resulting from Processing In Vivo Has 5′-Phosphomonoester and 3′-Hydroxyl Termini: Implications for the RNase and RNA Ligase Involved in Replication
María-Eugenia Gas, Diego Molina-Serrano, Carmen Hernández, Ricardo Flores, José-Antonio Daròs

Virus-Cell Interactions

Virus-Cell Interactions
Small-Ruminant Lentivirus Enhances PrP^Sc Accumulation in Cultured Sheep Microglial Cells
James B. Stanton, Donald P. Knowles, Katherine I. O'Rourke, Lynn M. Herrmann-Hoesing, Bruce A. Mathison, Timothy V. Baszler
Virus-Cell Interactions
Scrapie-Induced Defects in Learning and Memory of Transgenic Mice Expressing Anchorless Prion Protein Are Associated with Alterations in the Gamma Aminobutyric Acid-Ergic Pathway
Matthew J. Trifilo, Manuel Sanchez-Alavez, Laura Solforosi, Joie Bernard-Trifilo, Stefan Kunz, Dorian McGavern, Michael B. A. Oldstone
Virus-Cell Interactions
Ectromelia Virus Encodes a Novel Family of F-Box Proteins That Interact with the SCF Complex
Nick van Buuren, Brianne Couturier, Yue Xiong, Michele Barry
Virus-Cell Interactions
Human Immunodeficiency Virus Type 1 Replication and Regulation of APOBEC3G by Peptidyl Prolyl Isomerase Pin1
Koichi Watashi, Mohammad Khan, Venkat R. K. Yedavalli, Man Lung Yeung, Klaus Strebel, Kuan-Teh Jeang
Virus-Cell Interactions
Bap31 Is a Novel Target of the Human Papillomavirus E5 Protein
Jennifer A. Regan, Laimonis A. Laimins
Virus-Cell Interactions
Vaccinia Virus WR53.5/F14.5 Protein Is a New Component of Intracellular Mature Virus and Is Important for Calcium-Independent Cell Adhesion and Vaccinia Virus Virulence in Mice
Roza Izmailyan, Wen Chang
Virus-Cell Interactions
Efficient Quiescent Infection of Normal Human Diploid Fibroblasts with Wild-Type Herpes Simplex Virus Type 1
Robert McMahon, Derek Walsh
Virus-Cell Interactions
The Vaccinia Virus Gene I2L Encodes a Membrane Protein with an Essential Role in Virion Entry
R. Jeremy Nichols, Eleni Stanitsa, Bethany Unger, Paula Traktman

Structure and Assembly

Structure and Assembly
Possible Role for Cellular Karyopherins in Regulating Polyomavirus and Papillomavirus Capsid Assembly
Gregory Bird, Malinda O'Donnell, Junona Moroianu, Robert L. Garcea
Structure and Assembly
Subviral Particle Release Determinants of Prototype Foamy Virus
Annett Stange, Daniel Lüftenegger, Juliane Reh, Winfried Weissenhorn, Dirk Lindemann
Structure and Assembly
Kinesin KIF4 Regulates Intracellular Trafficking and Stability of the Human Immunodeficiency Virus Type 1 Gag Polyprotein
Nathaniel W. Martinez, Xiaoxiao Xue, Reem G. Berro, Geri Kreitzer, Marilyn D. Resh
Structure and Assembly
The Influenza Virus M2 Protein Cytoplasmic Tail Interacts with the M1 Protein and Influences Virus Assembly at the Site of Virus Budding
Benjamin J. Chen, George P. Leser, David Jackson, Robert A. Lamb
Structure and Assembly
Amino Acid Preferences of Retroviral Proteases for Amino-Terminal Positions in a Type 1 Cleavage Site
Helga Eizert, Pálma Bander, Péter Bagossi, Tamás Sperka, Gabriella Miklóssy, Péter Boross, Irene T. Weber, József Tözsér
Structure and Assembly
Retroviral Nucleocapsid Proteins Display Nonequivalent Levels of Nucleic Acid Chaperone Activity
Kristen M. Stewart-Maynard, Margareta Cruceanu, Fei Wang, My-Nuong Vo, Robert J. Gorelick, Mark C. Williams, Ioulia Rouzina, Karin Musier-Forsyth
Structure and Assembly
Small-Molecule Effectors of Hepatitis B Virus Capsid Assembly Give Insight into Virus Life Cycle
Christina Bourne, Sejin Lee, Bollu Venkataiah, Angela Lee, Brent Korba, M. G. Finn, Adam Zlotnick
Structure and Assembly
Adenovirus IVa2 Protein Binds ATP
Philomena Ostapchuk, Patrick Hearing

Vaccines and Antiviral Agents

Vaccines and Antiviral Agents
Sequestering of the Prehairpin Intermediate of gp41 by Peptide N36^Mut(e,g) Potentiates the Human Immunodeficiency Virus Type 1 Neutralizing Activity of Monoclonal Antibodies Directed against the N-Terminal Helical Repeat of gp41
Elena Gustchina, Carole A Bewley, G. Marius Clore
Vaccines and Antiviral Agents
Gag-Specific Cytotoxic T-Lymphocyte-Based Control of Primary Simian Immunodeficiency Virus Replication in a Vaccine Trial
Miki Kawada, Tetsuo Tsukamoto, Hiroyuki Yamamoto, Nami Iwamoto, Kyoko Kurihara, Akiko Takeda, Chikaya Moriya, Hiroaki Takeuchi, Hirofumi Akari, Tetsuro Matano

Cellular Response to Infection

Cellular Response to Infection
Sendai Virus C Protein Plays a Role in Restricting PKR Activation by Limiting the Generation of Intracellular Double-Stranded RNA
Kenji Takeuchi, Takayuki Komatsu, Yoshinori Kitagawa, Kiyonao Sada, Bin Gotoh
Cellular Response to Infection
Cell Cycle-Independent Expression of Immediate-Early Gene 3 Results in G₁ and G₂ Arrest in Murine Cytomegalovirus-Infected Cells
Lüder Wiebusch, Anke Neuwirth, Linus Grabenhenrich, Sebastian Voigt, Christian Hagemeier

Gene Delivery

Gene Delivery
Construction of a Fully Retargeted Herpes Simplex Virus 1 Recombinant Capable of Entering Cells Solely via Human Epidermal Growth Factor Receptor 2
Laura Menotti, Arianna Cerretani, Hartmut Hengel, Gabriella Campadelli-Fiume

Transformation and Oncogenesis

Transformation and Oncogenesis
Latent Membrane Protein 1 of Epstein-Barr Virus Activates the hTERT Promoter and Enhances Telomerase Activity in B Lymphocytes
Liliana Terrin, Jessica Dal Col, Enrica Rampazzo, Paola Zancai, Moreno Pedrotti, Grazia Ammirabile, Stefano Bergamin, Silvana Rizzo, Riccardo Dolcetti, Anita De Rossi

Genetic Diversity and Evolution

Genetic Diversity and Evolution
Gain, Preservation, and Loss of a Group 1a Coronavirus Accessory Glycoprotein
Alessio Lorusso, Nicola Decaro, Pepijn Schellen, Peter J. M. Rottier, Canio Buonavoglia, Bert-Jan Haijema, Raoul J. de Groot

Letters to the Editor

LETTER TO THE EDITOR | Letter to the Editor | Letters to the Editor
Transitory Viremic Surges in a Human Immunodeficiency Virus-Positive Elite Controller Can Shift the Cellular Transcriptome Profile: a Word of Caution for Microarray Studies
Jing Qin Wu, Bin Wang, Nitin K. Saksena

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Table of Contents

Spotlight

Pathogenesis and Immunity

Genome Replication and Regulation of Viral Gene Expression

Virus-Cell Interactions

Structure and Assembly

Vaccines and Antiviral Agents

Cellular Response to Infection

Gene Delivery

Transformation and Oncogenesis

Genetic Diversity and Evolution

Letters to the Editor

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