Journal of Virology: 82 (2)

January 15, 2008; Volume 82,Issue 2

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Articles of Significant Interest Selected from This Issue by the Editors

Guest Commentaries

GUEST COMMENTARY
The Influenza Virus Resource at the National Center for Biotechnology Information
Yiming Bao, Pavel Bolotov, Dmitry Dernovoy, Boris Kiryutin, Leonid Zaslavsky, Tatiana Tatusova, Jim Ostell, David Lipman

Virus-Cell Interactions

Virus-Cell Interactions
Downregulation of the T-Cell Receptor Complex and Impairment of T-Cell Activation by Human Herpesvirus 6 U24 Protein
Brian M. Sullivan, Laurent Coscoy
Virus-Cell Interactions
The Antiapoptotic Herpes Simplex Virus Glycoprotein J Localizes to Multiple Cellular Organelles and Induces Reactive Oxygen Species Formation
Martine Aubert, Zheng Chen, Robin Lang, Chung H. Dang, Carla Fowler, Derek D. Sloan, Keith R. Jerome
Virus-Cell Interactions
Effects of Partial Deletions within the Human Immunodeficiency Virus Type 1 V3 Loop on Coreceptor Tropism and Sensitivity to Entry Inhibitors
Katrina M. Nolan, Andrea P. O. Jordan, James A. Hoxie
Virus-Cell Interactions
Engineered Disulfide Bonds in Herpes Simplex Virus Type 1 gD Separate Receptor Binding from Fusion Initiation and Viral Entry
Eric Lazear, Andrea Carfi, J. Charles Whitbeck, Tina M. Cairns, Claude Krummenacher, Gary H. Cohen, Roselyn J. Eisenberg
Virus-Cell Interactions
Characterization of the Human Herpesvirus 6 U69 Gene Product and Identification of Its Nuclear Localization Signal
Yuji Isegawa, Yoichi Miyamoto, Yoshinari Yasuda, Katsunori Semi, Kenji Tsujimura, Rikiro Fukunaga, Atsushi Ohshima, Yasuhiro Horiguchi, Yoshihiro Yoneda, Nakaba Sugimoto
Virus-Cell Interactions | Spotlight
The Spike Glycoprotein of Murine Coronavirus MHV-JHM Mediates Receptor-Independent Infection and Spread in the Central Nervous Systems of Ceacam1a^−/− Mice
Tanya A. Miura, Emily A. Travanty, Lauren Oko, Helle Bielefeldt-Ohmann, Susan R. Weiss, Nicole Beauchemin, Kathryn V. Holmes
Virus-Cell Interactions | Spotlight
Paramyxovirus-Induced Shutoff of Host and Viral Protein Synthesis: Role of the P and V Proteins in Limiting PKR Activation
Maria D. Gainey, Patrick J. Dillon, Kimberly M. Clark, Mary J. Manuse, Griffith D. Parks
Virus-Cell Interactions
Loss of Protein Kinase PKR Expression in Human HeLa Cells Complements the Vaccinia Virus E3L Deletion Mutant Phenotype by Restoration of Viral Protein Synthesis
Ping Zhang, Bertram L. Jacobs, Charles E. Samuel
Virus-Cell Interactions
An Ectromelia Virus Protein That Interacts with Chemokines through Their Glycosaminoglycan Binding Domain
M. Begoña Ruiz-Argüello, Vincent P. Smith, Gabriele S. V. Campanella, Françoise Baleux, Fernando Arenzana-Seisdedos, Andrew D. Luster, Antonio Alcami
Virus-Cell Interactions
New World Clade B Arenaviruses Can Use Transferrin Receptor 1 (TfR1)-Dependent and -Independent Entry Pathways, and Glycoproteins from Human Pathogenic Strains Are Associated with the Use of TfR1
Meg L. Flanagan, Jill Oldenburg, Therese Reignier, Nathalia Holt, Genevieve A. Hamilton, Vanessa K. Martin, Paula M. Cannon
Virus-Cell Interactions
Human Immunodeficiency Virus Type 1 Vif Functionally Interacts with Diverse APOBEC3 Cytidine Deaminases and Moves with Them between Cytoplasmic Sites of mRNA Metabolism
Mariana Marin, Sheetal Golem, Kristine M. Rose, Susan L. Kozak, David Kabat
Virus-Cell Interactions
The U95 Protein of Human Herpesvirus 6B Interacts with Human GRIM-19: Silencing of U95 Expression Reduces Viral Load and Abrogates Loss of Mitochondrial Membrane Potential
W. M. Yeo, Yuji Isegawa, Vincent T. K. Chow
Virus-Cell Interactions
Modulation of Human Immunodeficiency Virus Type 1 Infectivity through Incorporation of Tetraspanin Proteins
Kei Sato, Jun Aoki, Naoko Misawa, Eriko Daikoku, Kouichi Sano, Yuetsu Tanaka, Yoshio Koyanagi
Virus-Cell Interactions
Transcriptome Analysis of NF-κB- and Phosphatidylinositol 3-Kinase-Regulated Genes in Human Cytomegalovirus-Infected Monocytes
Gary Chan, Elizabeth R. Bivins-Smith, M. Shane Smith, Andrew D. Yurochko

Cellular Response to Infection

Cellular Response to Infection
Establishment and Maintenance of the Innate Antiviral Response to West Nile Virus Involves both RIG-I and MDA5 Signaling through IPS-1
Brenda L. Fredericksen, Brian C. Keller, Jamie Fornek, Michael G. Katze, Michael Gale
Cellular Response to Infection
A Host Factor Involved in Hypovirus Symptom Expression in the Chestnut Blight Fungus, Cryphonectria parasitica
M. Iqbal Faruk, Ana Eusebio-Cope, Nobuhiro Suzuki

Gene Delivery

Gene Delivery
Modification of Adenovirus Capsid with a Designed Protein Ligand Yields a Gene Vector Targeted to a Major Molecular Marker of Cancer
Natalya Belousova, Galina Mikheeva, Juri Gelovani, Victor Krasnykh
Gene Delivery
Herpes Simplex Virus Type 1 Preferentially Targets Human Colon Carcinoma: Role of Extracellular Matrix
Dror Kolodkin-Gal, Gideon Zamir, Yair Edden, Eli Pikarsky, Alon Pikarsky, Hillel Haim, Yosef S. Haviv, Amos Panet

Pathogenesis and Immunity

Pathogenesis and Immunity
Removal of a Single N-Linked Glycan in Human Immunodeficiency Virus Type 1 gp120 Results in an Enhanced Ability To Induce Neutralizing Antibody Responses
Yun Li, Bradley Cleveland, Igor Klots, Bruce Travis, Barbra A. Richardson, David Anderson, David Montefiori, Patricia Polacino, Shiu-Lok Hu
Pathogenesis and Immunity
Clonal Focusing of Epitope-Specific CD8⁺ T Lymphocytes in Rhesus Monkeys following Vaccination and Simian-Human Immunodeficiency Virus Challenge
Pritha Sen, William A. Charini, Ramu A. Subbramanian, Edwin R. Manuel, Marcelo J. Kuroda, Patrick A. Autissier, Norman L. Letvin
Pathogenesis and Immunity
Human Astrovirus Coat Protein Inhibits Serum Complement Activation via C1, the First Component of the Classical Pathway
Rheba S. Bonaparte, Pamela S. Hair, Deepa Banthia, Dawn M. Marshall, Kenji M. Cunnion, Neel K. Krishna
Pathogenesis and Immunity
The Major Histocompatibility Complex Class II Alleles Mamu-DRB1*1003 and -DRB1*0306 Are Enriched in a Cohort of Simian Immunodeficiency Virus-Infected Rhesus Macaque Elite Controllers
Juan P. Giraldo-Vela, Richard Rudersdorf, Chungwon Chung, Ying Qi, Lyle T. Wallace, Benjamin Bimber, Gretta J. Borchardt, Debra L. Fisk, Chrystal E. Glidden, John T. Loffredo, Shari M. Piaskowski, Jessica R. Furlott, Juan P. Morales-Martinez, Nancy A. Wilson, William M. Rehrauer, Jeffrey D. Lifson, Mary Carrington, David I. Watkins
Pathogenesis and Immunity
Human Immunodeficiency Virus Type 1 Vpu Protein Interacts with CD74 and Modulates Major Histocompatibility Complex Class II Presentation
Amjad Hussain, Clement Wesley, Mohammad Khalid, Ashutosh Chaudhry, Shahid Jameel
Pathogenesis and Immunity
Subtype-Specific Conformational Differences within the V3 Region of Subtype B and Subtype C Human Immunodeficiency Virus Type 1 Env Proteins
Milloni B. Patel, Noah G. Hoffman, Ronald Swanstrom
Pathogenesis and Immunity
Infection-Enhancing and -Neutralizing Activities of Mouse Monoclonal Antibodies against Dengue Type 2 and 4 Viruses Are Controlled by Complement Levels
Atsushi Yamanaka, Saori Kosugi, Eiji Konishi
Pathogenesis and Immunity
The First Hypervariable Region of the gp120 Env Glycoprotein Defines the Neutralizing Susceptibility of Heterologous Human Immunodeficiency Virus Type 1 Isolates to Neutralizing Antibodies Elicited by the SF162gp140 Immunogen
Lance K. Ching, Giorgos Vlachogiannis, Katherine A. Bosch, Leonidas Stamatatos
Pathogenesis and Immunity
Isolation and Characterization of Broadly Neutralizing Human Monoclonal Antibodies to the E1 Glycoprotein of Hepatitis C Virus
Jean-Christophe Meunier, Rodney S. Russell, Vera Goossens, Sofie Priem, Hugo Walter, Erik Depla, Ann Union, Kristina N. Faulk, Jens Bukh, Suzanne U. Emerson, Robert H. Purcell
Pathogenesis and Immunity
Protease Activity, Self Interaction, and Small Interfering RNA Binding of the Silencing Suppressor P1b from Cucumber Vein Yellowing Ipomovirus
Adrian Valli, Gabriela Dujovny, Juan Antonio García
Pathogenesis and Immunity
Identification of a Broadly Cross-Reacting and Neutralizing Human Monoclonal Antibody Directed against the Hepatitis C Virus E2 Protein
Mario Perotti, Nicasio Mancini, Roberta A. Diotti, Alexander W. Tarr, Jonathan K. Ball, Ania Owsianka, R. Adair, Arvind H. Patel, Massimo Clementi, Roberto Burioni
Pathogenesis and Immunity
Extending the Cytoplasmic Tail of the Influenza A Virus M2 Protein Leads to Reduced Virus Replication In Vivo but Not In Vitro
Wai-Hong Wu, Andrew Pekosz

Vaccines and Antiviral Agents

Vaccines and Antiviral Agents | Spotlight
Antibody Profiling by Proteome Microarray Reveals the Immunogenicity of the Attenuated Smallpox Vaccine Modified Vaccinia Virus Ankara Is Comparable to That of Dryvax
D. Huw Davies, Linda S. Wyatt, Frances K. Newman, Patricia L. Earl, Sookhee Chun, Jenny E. Hernandez, Douglas M. Molina, Siddiqua Hirst, Bernard Moss, Sharon E. Frey, Philip L. Felgner
Vaccines and Antiviral Agents
Broad Antiretroviral Activity and Resistance Profile of the Novel Human Immunodeficiency Virus Integrase Inhibitor Elvitegravir (JTK-303/GS-9137)
Kazuya Shimura, Eiichi Kodama, Yasuko Sakagami, Yuji Matsuzaki, Wataru Watanabe, Kazunobu Yamataka, Yasuo Watanabe, Yoshitsugu Ohata, Satoki Doi, Motohide Sato, Mitsuki Kano, Satoru Ikeda, Masao Matsuoka
Vaccines and Antiviral Agents
Novel Plant Virus-Based Vaccine Induces Protective Cytotoxic T-Lymphocyte-Mediated Antiviral Immunity through Dendritic Cell Maturation
Patrick Lacasse, Jérôme Denis, Réjean Lapointe, Denis Leclerc, Alain Lamarre

Structure and Assembly

Structure and Assembly
Role of Intermolecular Interactions of Vesicular Stomatitis Virus Nucleoprotein in RNA Encapsidation
Xin Zhang, Todd J. Green, Jun Tsao, Shihong Qiu, Ming Luo
Structure and Assembly | Spotlight
Intermolecular Interactions between Retroviral Gag Proteins in the Nucleus
Scott P. Kenney, Timothy L. Lochmann, Cullen L. Schmid, Leslie J. Parent

Genome Replication and Regulation of Viral Gene Expression

Genome Replication and Regulation of Viral Gene Expression
Nucleolar Targeting of Hepatitis Delta Antigen Abolishes Its Ability To Initiate Viral Antigenomic RNA Replication
Wen-Hung Huang, Yen-Shun Chen, Pei-Jer Chen
Genome Replication and Regulation of Viral Gene Expression
Mutations in the U5 Region Adjacent to the Primer Binding Site Affect tRNA Cleavage by Human Immunodeficiency Virus Type 1 Reverse Transcriptase In Vivo
Jangsuk Oh, Mary Jane McWilliams, John G. Julias, Stephen H. Hughes
Genome Replication and Regulation of Viral Gene Expression
Cytoplasmic Domain of Influenza B Virus BM2 Protein Plays Critical Roles in Production of Infectious Virus
Masaki Imai, Kazunori Kawasaki, Takato Odagiri
Genome Replication and Regulation of Viral Gene Expression
A Conserved Motif in Region V of the Large Polymerase Proteins of Nonsegmented Negative-Sense RNA Viruses That Is Essential for mRNA Capping
Jianrong Li, Amal Rahmeh, Marco Morelli, Sean P. J. Whelan
Genome Replication and Regulation of Viral Gene Expression
Varicella-Zoster Virus Glycoprotein M Homolog Is Glycosylated, Is Expressed on the Viral Envelope, and Functions in Virus Cell-to-Cell Spread
Yoshiaki Yamagishi, Tomohiko Sadaoka, Hironori Yoshii, Pranee Somboonthum, Takayoshi Imazawa, Kazuhiro Nagaike, Keiichi Ozono, Koichi Yamanishi, Yasuko Mori
Genome Replication and Regulation of Viral Gene Expression
A cis Element between the TATA Box and the Transcription Start Site of the Major Immediate-Early Promoter of Human Cytomegalovirus Determines Efficiency of Viral Replication
Hiroki Isomura, Mark F. Stinski, Ayumi Kudoh, Sanae Nakayama, Takayuki Murata, Yoshitaka Sato, Satoko Iwahori, Tatsuya Tsurumi
Genome Replication and Regulation of Viral Gene Expression
The 3′ Untranslated Region of Sindbis Virus Represses Deadenylation of Viral Transcripts in Mosquito and Mammalian Cells
Nicole L. Garneau, Kevin J. Sokoloski, Mateusz Opyrchal, C. Preston Neff, Carol J. Wilusz, Jeffrey Wilusz

Transformation and Oncogenesis

Transformation and Oncogenesis
Influence of the Viral Regulatory Region on Tumor Induction by Simian Virus 40 in Hamsters
Vojtech Sroller, Regis A. Vilchez, A. Renee Stewart, Connie Wong, Janet S. Butel
Transformation and Oncogenesis
Murine Gammaherpesvirus 68 Genes both Induce and Suppress Lymphoproliferative Disease
Vera L. Tarakanova, Friederike Kreisel, Douglas W. White, Herbert W. Virgin
Transformation and Oncogenesis | Spotlight
The Cigarette Smoke Carcinogen Benzo[a]pyrene Enhances Human Papillomavirus Synthesis
Samina Alam, Michael J. Conway, Horng-Shen Chen, Craig Meyers

Genetic Diversity and Evolution

Genetic Diversity and Evolution
Phylogenetic Evidence for Rapid Rates of Molecular Evolution in the Single-Stranded DNA Begomovirus Tomato Yellow Leaf Curl Virus
Siobain Duffy, Edward C. Holmes

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Table of Contents

Spotlight

Guest Commentaries

Virus-Cell Interactions

Cellular Response to Infection

Gene Delivery

Pathogenesis and Immunity

Vaccines and Antiviral Agents

Structure and Assembly

Genome Replication and Regulation of Viral Gene Expression

Transformation and Oncogenesis

Genetic Diversity and Evolution

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