Journal of Virology: 82 (18)

September 15, 2008; Volume 82,Issue 18

Spotlight

Spotlight
Articles of Significant Interest Selected from This Issue by the Editors

Pathogenesis and Immunity

Pathogenesis and Immunity
Tumor Necrosis Factor Alpha Protects against Lethal West Nile Virus Infection by Promoting Trafficking of Mononuclear Leukocytes into the Central Nervous System
Bimmi Shrestha, Bo Zhang, Whitney E. Purtha, Robyn S. Klein, Michael S. Diamond
Pathogenesis and Immunity
Matrix Metalloproteinase 9 Facilitates West Nile Virus Entry into the Brain
Penghua Wang, Jianfeng Dai, Fengwei Bai, Kok-Fai Kong, Susan J. Wong, Ruth R. Montgomery, Joseph A. Madri, Erol Fikrig
Pathogenesis and Immunity
The Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 4E10 Monoclonal Antibody Is Better Adapted to Membrane-Bound Epitope Recognition and Blocking than 2F5
Nerea Huarte, Maier Lorizate, Rubén Maeso, Renate Kunert, Rocio Arranz, José M. Valpuesta, José L. Nieva
Pathogenesis and Immunity
Common Marmosets (Callithrix jacchus) as a Nonhuman Primate Model To Assess the Virulence of Eastern Equine Encephalitis Virus Strains
A. Paige Adams, Judith F. Aronson, Suzette D. Tardif, Jean L. Patterson, Kathleen M. Brasky, Robert Geiger, Melissa de la Garza, Ricardo Carrion, Scott C. Weaver
Pathogenesis and Immunity
Preferential Cytolysis of Peripheral Memory CD4⁺ T Cells by In Vitro X4-Tropic Human Immunodeficiency Virus Type 1 Infection before the Completion of Reverse Transcription
Yan Zhou, Lin Shen, Hung-Chih Yang, Robert F. Siliciano
Pathogenesis and Immunity
Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection
Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L. Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, Bruce D. Walker
Pathogenesis and Immunity
Influenza A Virus Matrix Protein 1-Specific Human CD8⁺ T-Cell Response Induced in Trivalent Inactivated Vaccine Recipients
Masanori Terajima, John Cruz, Anita M. Leporati, Laura Orphin, Jenny Aurielle B. Babon, Mary Dawn T. Co, Pamela Pazoles, Julie Jameson, Francis A. Ennis
Pathogenesis and Immunity | Spotlight
Differential Antigen Presentation Kinetics of CD8⁺ T-Cell Epitopes Derived from the Same Viral Protein
Jonah B. Sacha, Matthew R. Reynolds, Matthew B. Buechler, Chungwon Chung, Anna K. Jonas, Lyle T. Wallace, Andrea M. Weiler, Wonhee Lee, Shari M. Piaskowski, Taeko Soma, Thomas C. Friedrich, Nancy A. Wilson, David I. Watkins
Pathogenesis and Immunity
Natural Killer Cells Regulate T-Cell Proliferation during Human Parainfluenza Virus Type 3 Infection
Cariosa M. Noone, Elaine Paget, Ellen A. Lewis, Marius R. Loetscher, Robert W. Newman, Patricia A. Johnson

Cellular Response to Infection

Cellular Response to Infection
Human Parainfluenza Virus Type 1 C Proteins Are Nonessential Proteins That Inhibit the Host Interferon and Apoptotic Responses and Are Required for Efficient Replication in Nonhuman Primates
Emmalene J. Bartlett, Ann-Marie Cruz, Janice Esker, Adam Castaño, Henrick Schomacker, Sonja R. Surman, Margaret Hennessey, Jim Boonyaratanakornkit, Raymond J. Pickles, Peter L. Collins, Brian R. Murphy, Alexander C. Schmidt
Cellular Response to Infection | Spotlight
Viral Genome Methylation as an Epigenetic Defense against Geminiviruses
Priya Raja, Bradley C. Sanville, R. Cody Buchmann, David M. Bisaro
Cellular Response to Infection
Distinct Requirements of Adenovirus E1b55K Protein for Degradation of Cellular Substrates
Rachel A. Schwartz, Seema S. Lakdawala, Heather D. Eshleman, Matthew R. Russell, Christian T. Carson, Matthew D. Weitzman
Cellular Response to Infection
The NY-1 Hantavirus Gn Cytoplasmic Tail Coprecipitates TRAF3 and Inhibits Cellular Interferon Responses by Disrupting TBK1-TRAF3 Complex Formation
Peter J. Alff, Nandini Sen, Elena Gorbunova, Irina N. Gavrilovskaya, Erich R. Mackow
Cellular Response to Infection
Autophagosome Supports Coxsackievirus B3 Replication in Host Cells
Jerry Wong, Jingchun Zhang, Xiaoning Si, Guang Gao, Ivy Mao, Bruce M. McManus, Honglin Luo

Genome Replication and Regulation of Viral Gene Expression

Genome Replication and Regulation of Viral Gene Expression
A Hepatitis C Virus cis-Acting Replication Element Forms a Long-Range RNA-RNA Interaction with Upstream RNA Sequences in NS5B
Sinéad Diviney, Andrew Tuplin, Madeleine Struthers, Victoria Armstrong, Richard M. Elliott, Peter Simmonds, David J. Evans
Genome Replication and Regulation of Viral Gene Expression | Spotlight
Human Cytomegalovirus Infection Alters the Expression of Cellular MicroRNA Species That Affect Its Replication
Fu-Zhang Wang, Frank Weber, Carlo Croce, Chang-Gong Liu, Xudong Liao, Philip E. Pellett
Genome Replication and Regulation of Viral Gene Expression
Epstein-Barr Virus BART MicroRNAs Are Produced from a Large Intron prior to Splicing
Rachel Hood Edwards, Aron R. Marquitz, Nancy Raab-Traub
Genome Replication and Regulation of Viral Gene Expression
An Insect Virus-Encoded MicroRNA Regulates Viral Replication
Mazhar Hussain, Ryan J. Taft, Sassan Asgari
Genome Replication and Regulation of Viral Gene Expression
Functional Analysis of the Complex trans-Activating Response Element RNA Structure in Simian Immunodeficiency Virus
Mireille Centlivre, Bep Klaver, Ben Berkhout, Atze T. Das
Genome Replication and Regulation of Viral Gene Expression
Molecular Defects Caused by Temperature-Sensitive Mutations in Semliki Forest Virus nsP1
Valeria Lulla, Dorothea L. Sawicki, Stanley G. Sawicki, Aleksei Lulla, Andres Merits, Tero Ahola
Genome Replication and Regulation of Viral Gene Expression
Nontemplated Terminal Nucleotidyltransferase Activity of Double-Stranded RNA Bacteriophage φ6 RNA-Dependent RNA Polymerase
Minna M. Poranen, Minni R. L. Koivunen, Dennis H. Bamford
Genome Replication and Regulation of Viral Gene Expression
Functional Homologies between Avian and Human Alphaherpesvirus VP22 Proteins in Cell-to-Cell Spreading as Revealed by a New cis-Complementation Assay
C. Blondeau, D. Marc, K. Courvoisier, J.-F. Vautherot, C. Denesvre

Virus-Cell Interactions

Virus-Cell Interactions
Enzootic Nasal Tumor Virus Envelope Requires a Very Acidic pH for Fusion Activation and Infection
Marceline Côté, Thomas J. Kucharski, Shan-Lu Liu
Virus-Cell Interactions
Identification of an Arginine-Rich Motif in Human Papillomavirus Type 1 E1^E4 Protein Necessary for E4-Mediated Inhibition of Cellular DNA Synthesis In Vitro and in Cells
Sally Roberts, Sarah R. Kingsbury, Kai Stoeber, Gillian L. Knight, Phillip H. Gallimore, Gareth H. Williams
Virus-Cell Interactions
Heparan Sulfate-Binding Foot-and-Mouth Disease Virus Enters Cells via Caveola-Mediated Endocytosis
Vivian O'Donnell, Michael LaRocco, Barry Baxt
Virus-Cell Interactions
A Single Amino Acid Residue Change in the P Protein of Parainfluenza Virus 5 Elevates Viral Gene Expression
Khalid A. Timani, Dengyun Sun, Minghao Sun, Celia Keim, Yuan Lin, Phuong Tieu Schmitt, Anthony P. Schmitt, Biao He
Virus-Cell Interactions
Mapping of the CXCR4 Binding Site within Variable Region 3 of the Feline Immunodeficiency Virus Surface Glycoprotein
Magnus Sundstrom, Rebecca L. White, Aymeric de Parseval, K. Jagannadha Sastry, Garrett Morris, Chris K. Grant, John H. Elder
Virus-Cell Interactions | Spotlight
Induction of the Gα_q Signaling Cascade by the Human Immunodeficiency Virus Envelope Is Required for Virus Entry
Brooke Harmon, Lee Ratner
Virus-Cell Interactions
Differential Cholesterol Binding by Class II Fusion Proteins Determines Membrane Fusion Properties
M. Umashankar, Claudia Sánchez-San Martín, Maofu Liao, Brigid Reilly, Alice Guo, Gwen Taylor, Margaret Kielian
Virus-Cell Interactions
Human Immunodeficiency Virus Type 1 Vif Induces Cell Cycle Delay via Recruitment of the Same E3 Ubiquitin Ligase Complex That Targets APOBEC3 Proteins for Degradation
Jason L. DeHart, Alberto Bosque, Reuben S. Harris, Vicente Planelles

Structure and Assembly

Structure and Assembly
Presence of the Adenovirus IVa2 Protein at a Single Vertex of the Mature Virion
Joan B. Christensen, Serena A. Byrd, Angela K. Walker, John R. Strahler, Philip C. Andrews, Michael J. Imperiale
Structure and Assembly
S Acylation of the Hemagglutinin of Influenza Viruses: Mass Spectrometry Reveals Site-Specific Attachment of Stearic Acid to a Transmembrane Cysteine
Larisa V. Kordyukova, Marina V. Serebryakova, Ludmila A. Baratova, Michael Veit

Genetic Diversity and Evolution

Genetic Diversity and Evolution | Spotlight
Novel Astroviruses in Insectivorous Bats
D. K. W. Chu, L. L. M. Poon, Y. Guan, J. S. M. Peiris
Genetic Diversity and Evolution
Changes in Population Dynamics during Long-Term Evolution of Sabin Type 1 Poliovirus in an Immunodeficient Patient
John K. Odoom, Zaira Yunus, Glynis Dunn, Philip D. Minor, Javier Martín
Genetic Diversity and Evolution
Temporal and Spatial Dynamics of Human Immunodeficiency Virus Type 1 Circulating Recombinant Forms 08_BC and 07_BC in Asia
Kok Keng Tee, Oliver G. Pybus, Xiao-Jie Li, Xiaoxu Han, Hong Shang, Adeeba Kamarulzaman, Yutaka Takebe
Genetic Diversity and Evolution
Analysis of Natural Sequence Variation and Covariation in Human Immunodeficiency Virus Type 1 Integrase
Richard E. Myers, Deenan Pillay

Vaccines and Antiviral Agents

Vaccines and Antiviral Agents
Immune Response in the Absence of Neurovirulence in Mice Infected with M Protein Mutant Vesicular Stomatitis Virus
Maryam Ahmed, Tracie R. Marino, Shelby Puckett, Nancy D. Kock, Douglas S. Lyles

Letters to the Editor

Letter to the Editor
Not So Fast on Recombination Analysis of Newcastle Disease Virus
Claudio L. Afonso

Errata

Erratum
Role of Initiating Nucleoside Triphosphate Concentrations in the Regulation of Influenza Virus Replication and Transcription
Frank T. Vreede, Hugh Gifford, George G. Brownlee

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Table of Contents

Spotlight

Pathogenesis and Immunity

Cellular Response to Infection

Genome Replication and Regulation of Viral Gene Expression

Virus-Cell Interactions

Structure and Assembly

Genetic Diversity and Evolution

Vaccines and Antiviral Agents

Letters to the Editor

Errata

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