Journal of Virology: 82 (17)

September 1, 2008; Volume 82,Issue 17

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Articles of Significant Interest Selected from This Issue by the Editors

Minireviews

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Viral Proteins Interfering with Antigen Presentation Target the Major Histocompatibility Complex Class I Peptide-Loading Complex
Gustav Røder, Linda Geironson, Iain Bressendorff, Kajsa Paulsson

Structure and Assembly

Structure and Assembly
Capsid Proteins from Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus SIV_mac Can Coassemble into Mature Cores of Infectious Viruses
Jianbo Chen, Vinay K. Pathak, Weiqun Peng, Wei-Shau Hu
Structure and Assembly
Intramembrane Processing by Signal Peptide Peptidase Regulates the Membrane Localization of Hepatitis C Virus Core Protein and Viral Propagation
Kiyoko Okamoto, Yoshio Mori, Yasumasa Komoda, Toru Okamoto, Masayasu Okochi, Masatoshi Takeda, Tetsuro Suzuki, Kohji Moriishi, Yoshiharu Matsuura
Structure and Assembly
Comprehensive Characterization of Extracellular Herpes Simplex Virus Type 1 Virions
Sandra Loret, Ginette Guay, Roger Lippé
Structure and Assembly
Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1
Qi Zhao, Shuang Li, Fei Xue, Yilong Zou, Cheng Chen, Mark Bartlam, Zihe Rao
Structure and Assembly
Evidence for a Structural Relationship between BRCT Domains and the Helicase Domains of the Replication Initiators Encoded by the Polyomaviridae and Papillomaviridae Families of DNA Tumor Viruses
Anuradha Kumar, Woo S. Joo, Gretchen Meinke, Stephanie Moine, Elena N. Naumova, Peter A. Bullock
Structure and Assembly
Association of Respiratory Syncytial Virus M Protein with Viral Nucleocapsids Is Mediated by the M2-1 Protein
Dongsheng Li, David A. Jans, Phillip G. Bardin, Jayesh Meanger, John Mills, Reena Ghildyal

Cellular Response to Infection

Cellular Response to Infection
West Nile Virus Nonstructural Protein 1 Inhibits TLR3 Signal Transduction
Jason R. Wilson, Paola Florez de Sessions, Megan A. Leon, Frank Scholle
Cellular Response to Infection
Measles Virus Circumvents the Host Interferon Response by Different Actions of the C and V Proteins
Yuichiro Nakatsu, Makoto Takeda, Shinji Ohno, Yuta Shirogane, Masaharu Iwasaki, Yusuke Yanagi
Cellular Response to Infection
STAT2 Is a Primary Target for Measles Virus V Protein-Mediated Alpha/Beta Interferon Signaling Inhibition
Aparna Ramachandran, Jean-Patrick Parisien, Curt M. Horvath
Cellular Response to Infection
Intrahepatic Expression of Genes Affiliated with Innate and Adaptive Immune Responses Immediately after Invasion and during Acute Infection with Woodchuck Hepadnavirus
Clifford S. Guy, Patricia M. Mulrooney-Cousins, Norma D. Churchill, Tomasz I. Michalak

Virus-Cell Interactions

Virus-Cell Interactions
Changing the Protease Specificity for Activation of a Flavivirus, Tick-Borne Encephalitis Virus
Wolfgang Fischl, Sigrid Elshuber, Sabrina Schrauf, Christian W. Mandl
Virus-Cell Interactions
Effects of Hemagglutinin-Neuraminidase Protein Mutations on Cell-Cell Fusion Mediated by Human Parainfluenza Type 2 Virus
Masato Tsurudome, Machiko Nishio, Morihiro Ito, Shunsuke Tanahashi, Mitsuo Kawano, Hiroshi Komada, Yasuhiko Ito
Virus-Cell Interactions
CD81 Is a Central Regulator of Cellular Events Required for Hepatitis C Virus Infection of Human Hepatocytes
Michela Brazzoli, Alessia Bianchi, Sara Filippini, Amy Weiner, Qing Zhu, Mariagrazia Pizza, Stefania Crotta
Virus-Cell Interactions
Differential Requirements of the C Terminus of Nbs1 in Suppressing Adenovirus DNA Replication and Promoting Concatemer Formation
Seema S. Lakdawala, Rachel A. Schwartz, Kevin Ferenchak, Christian T. Carson, Brian P. McSharry, Gavin W. Wilkinson, Matthew D. Weitzman
Virus-Cell Interactions
Human Immunodeficiency Virus Type 1 Nef Expression Prevents AP-2-Mediated Internalization of the Major Histocompatibility Complex Class II-Associated Invariant Chain
Hélène Toussaint, François-Xavier Gobert, Michael Schindler, Carina Banning, Patrycja Kozik, Mabel Jouve, Frank Kirchhoff, Philippe Benaroch
Virus-Cell Interactions
Nuclear Pore Composition and Gating in Herpes Simplex Virus-Infected Cells
Helmut Hofemeister, Peter O'Hare
Virus-Cell Interactions
Loss of the N-Linked Glycan at Residue 173 of Human Parainfluenza Virus Type 1 Hemagglutinin-Neuraminidase Exposes a Second Receptor-Binding Site
Irina V. Alymova, Garry Taylor, Vasiliy P. Mishin, Makiko Watanabe, K. Gopal Murti, Kelli Boyd, Pooran Chand, Y. Sudhakara Babu, Allen Portner
Virus-Cell Interactions
Persistent Equine Arteritis Virus Infection in HeLa Cells
Jianqiang Zhang, Peter J. Timoney, N. James MacLachlan, William H. McCollum, Udeni B. R. Balasuriya
Virus-Cell Interactions
Targeting the Apoptotic Pathway with BCL-2 Inhibitors Sensitizes Primary Chronic Lymphocytic Leukemia Cells to Vesicular Stomatitis Virus-Induced Oncolysis
Vanessa Fonseca Tumilasci, Stephanie Olière, Thi Lien-Ahn Nguyên, April Shamy, John Bell, John Hiscott
Virus-Cell Interactions
A Replication-Defective Gammaherpesvirus Efficiently Establishes Long-Term Latency in Macrophages but Not in B Cells In Vivo
Haiyan Li, Kazufumi Ikuta, John W. Sixbey, Scott A. Tibbetts
Virus-Cell Interactions
Epstein-Barr Virus Latent Membrane Protein 2A Preferentially Signals through the Src Family Kinase Lyn
Mark Rovedo, Richard Longnecker
Virus-Cell Interactions
Linker Histones Are Mobilized during Infection with Herpes Simplex Virus Type 1
Kristen L. Conn, Michael J. Hendzel, Luis M. Schang
Virus-Cell Interactions
Structural Insight into the Human Immunodeficiency Virus Vif SOCS Box and Its Role in Human E3 Ubiquitin Ligase Assembly
Bradford J. Stanley, Elana S. Ehrlich, Leslie Short, Yunkai Yu, Zuoxiang Xiao, Xiao-Fang Yu, Yong Xiong
Virus-Cell Interactions
Human Respiratory Syncytial Virus Glycoproteins Are Not Required for Apical Targeting and Release from Polarized Epithelial Cells
Melissa Batonick, Antonius G. P. Oomens, Gail W. Wertz
Virus-Cell Interactions
Nuclear Import of the Varicella-Zoster Virus Latency-Associated Protein ORF63 in Primary Neurons Requires Expression of the Lytic Protein ORF61 and Occurs in a Proteasome-Dependent Manner
Matthew S. Walters, Christos A. Kyratsous, Shilin Wan, Saul Silverstein
Virus-Cell Interactions
Vaccinia Virus L1 Protein Is Required for Cell Entry and Membrane Fusion
Himani Bisht, Andrea S. Weisberg, Bernard Moss
Virus-Cell Interactions
Human Papillomavirus Type 16 E7 Oncoprotein Associates with E2F6
Margaret E. McLaughlin-Drubin, Kyung-Won Huh, Karl Münger
Virus-Cell Interactions
Pathways of Cross-Species Transmission of Synthetically Reconstructed Zoonotic Severe Acute Respiratory Syndrome Coronavirus
Timothy Sheahan, Barry Rockx, Eric Donaldson, Davide Corti, Ralph Baric
Virus-Cell Interactions
Vectorial Entry and Release of Hepatitis A Virus in Polarized Human Hepatocytes
Michelle J. Snooks, Purnima Bhat, Jason Mackenzie, Natalie A. Counihan, Nicola Vaughan, David A. Anderson
Virus-Cell Interactions
Activation of Akt through gp130 Receptor Signaling Is Required for Kaposi's Sarcoma-Associated Herpesvirus-Induced Lymphatic Reprogramming of Endothelial Cells
Valerie A. Morris, Almira S. Punjabi, Michael Lagunoff
Virus-Cell Interactions
Protein Kinase A-Dependent Step(s) in Hepatitis C Virus Entry and Infectivity
Michelle J. Farquhar, Helen J. Harris, Mandy Diskar, Sarah Jones, Christopher J. Mee, Søren U. Nielsen, Claire L. Brimacombe, Sonia Molina, Geoffrey L. Toms, Patrick Maurel, John Howl, Friedrich W. Herberg, Sven C. D. van IJzendoorn, Peter Balfe, Jane A. McKeating
Virus-Cell Interactions
STAT-1- and IRF-3-Dependent Pathways Are Not Essential for Repression of ICP0-Null Mutant Herpes Simplex Virus Type 1 in Human Fibroblasts
Roger D. Everett, Dan F. Young, Rick E. Randall, Anne Orr
Virus-Cell Interactions
Cathepsin L Functionally Cleaves the Severe Acute Respiratory Syndrome Coronavirus Class I Fusion Protein Upstream of Rather than Adjacent to the Fusion Peptide
Berend Jan Bosch, Willem Bartelink, Peter J. M. Rottier
Virus-Cell Interactions
Low-pH-Induced Membrane Fusion Mediated by Human Metapneumovirus F Protein Is a Rare, Strain-Dependent Phenomenon
Sander Herfst, Vicente Mas, Lorena S. Ver, Rutger J. Wierda, Albert D. M. E. Osterhaus, Ron A. M. Fouchier, José A. Melero
Virus-Cell Interactions
Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cells Express the Serotonin Receptor and Are Susceptible to JC Virus Infection
C. Schaumburg, B. A. O'Hara, T. E. Lane, W. J. Atwood
Virus-Cell Interactions
CD4 Binding Affinity Determines Human Immunodeficiency Virus Type 1-Induced Alpha Interferon Production in Plasmacytoid Dendritic Cells
Sabrina Haupt, Norbert Donhauser, Chawaree Chaipan, Philipp Schuster, Bridget Puffer, Rod S. Daniels, Thomas C. Greenough, Frank Kirchhoff, Barbara Schmidt
Virus-Cell Interactions
Molecular Characterization of the Heparin-Dependent Transduction Domain on the Capsid of a Novel Adeno-Associated Virus Isolate, AAV(VR-942)
Michael Schmidt, Lakshmanan Govindasamy, Sandra Afione, Nick Kaludov, Mavis Agbandje-McKenna, John A. Chiorini
Virus-Cell Interactions
A Functional F Analogue of Autographa californica Nucleopolyhedrovirus GP64 from the Agrotis segetum Granulovirus
Feifei Yin, Manli Wang, Ying Tan, Fei Deng, Just M. Vlak, Zhihong Hu, Hualin Wang
Virus-Cell Interactions
Efficient Multiplication of Human Metapneumovirus in Vero Cells Expressing the Transmembrane Serine Protease TMPRSS2
Yuta Shirogane, Makoto Takeda, Masaharu Iwasaki, Nobuhisa Ishiguro, Hiroki Takeuchi, Yuichiro Nakatsu, Maino Tahara, Hideaki Kikuta, Yusuke Yanagi

Pathogenesis and Immunity

Pathogenesis and Immunity
Preservation of FoxP3⁺ Regulatory T Cells in the Peripheral Blood of Human Immunodeficiency Virus Type 1-Infected Elite Suppressors Correlates with Low CD4⁺ T-Cell Activation
Amanda J. Chase, Hung-Chih Yang, Hao Zhang, Joel N. Blankson, Robert F. Siliciano
Pathogenesis and Immunity
Changes in p19^Arf Localization Accompany Apoptotic Crisis during Pre-B-Cell Transformation by Abelson Murine Leukemia Virus
Rebekah Stackpole Zimmerman, Naomi Rosenberg
Pathogenesis and Immunity
A Mouse-Passaged Dengue Virus Strain with Reduced Affinity for Heparan Sulfate Causes Severe Disease in Mice by Establishing Increased Systemic Viral Loads
Tyler R. Prestwood, Daniil M. Prigozhin, Kristin L. Sharar, Raphaël M. Zellweger, Sujan Shresta
Pathogenesis and Immunity
Genetic Characterization of Human Immunodeficiency Virus Type 1 in Elite Controllers: Lack of Gross Genetic Defects or Common Amino Acid Changes
Toshiyuki Miura, Mark A. Brockman, Chanson J. Brumme, Zabrina L. Brumme, Jonathan M. Carlson, Florencia Pereyra, Alicja Trocha, Marylyn M. Addo, Brian L. Block, Alissa C. Rothchild, Brett M. Baker, Theresa Flynn, Arne Schneidewind, Bin Li, Yaoyu E. Wang, David Heckerman, Todd M. Allen, Bruce D. Walker
Pathogenesis and Immunity
Interferon Regulatory Factor IRF-7 Induces the Antiviral Alpha Interferon Response and Protects against Lethal West Nile Virus Infection
Stephane Daffis, Melanie A. Samuel, Mehul S. Suthar, Brian C. Keller, Michael Gale, Michael S. Diamond
Pathogenesis and Immunity
Impact of Mucosal Inflammation on Cervical Human Immunodeficiency Virus (HIV-1)-Specific CD8 T-Cell Responses in the Female Genital Tract during Chronic HIV Infection
Pamela P. Gumbi, Nonhlanhla N. Nkwanyana, Alfred Bere, Wendy A. Burgers, Clive M. Gray, Anna-Lise Williamson, Margaret Hoffman, David Coetzee, Lynette Denny, Jo-Ann S. Passmore
Pathogenesis and Immunity
Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point
Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, Philip J. R. Goulder
Pathogenesis and Immunity
T Lymphocytes Contribute to Antiviral Immunity and Pathogenesis in Experimental Human Metapneumovirus Infection
Deepthi Kolli, Efthalia L. Bataki, LeAnne Spetch, Antonieta Guerrero-Plata, Alan M. Jewell, Pedro A. Piedra, Gregg N. Milligan, Roberto P. Garofalo, Antonella Casola
Pathogenesis and Immunity
Higher Homologous and Lower Cross-Reactive Gag-Specific T-Cell Responses in Human Immunodeficiency Virus Type 2 (HIV-2) Than in HIV-1 Infection
Wim Jennes, Makhtar Camara, Tandakha Dièye, Souleymane Mboup, Luc Kestens
Pathogenesis and Immunity
Nonstructural Proteins 1 and 2 of Respiratory Syncytial Virus Suppress Maturation of Human Dendritic Cells
Shirin Munir, Cyril Le Nouen, Cindy Luongo, Ursula J. Buchholz, Peter L. Collins, Alexander Bukreyev
Pathogenesis and Immunity
Characterization of Dengue Virus Complex-Specific Neutralizing Epitopes on Envelope Protein Domain III of Dengue 2 Virus
Gregory D. Gromowski, Nicholas D. Barrett, Alan D. T. Barrett
Pathogenesis and Immunity
Experimental Optic Neuritis Induced by a Demyelinating Strain of Mouse Hepatitis Virus
Kenneth S. Shindler, Lawrence C. Kenyon, Mahasweta Dutt, Susan T. Hingley, Jayasri Das Sarma
Pathogenesis and Immunity
Neurovirulence of Polytropic Murine Retrovirus Is Influenced by Two Separate Regions on Opposite Sides of the Envelope Protein Receptor Binding Domain
Karin E. Peterson, Susan Pourciau, Min Du, Rachel LaCasse, Melissa Pathmajeyan, David Poulsen, Mavis Agbandje-McKenna, Kathy Wehrly, Bruce Chesebro
Pathogenesis and Immunity
Temporary Depletion of CD11c⁺ Dendritic Cells Delays Lymphoinvasion after Intraperitonal Scrapie Infection
Sevda Cordier-Dirikoc, Joëlle Chabry

Genome Replication and Regulation of Viral Gene Expression

Genome Replication and Regulation of Viral Gene Expression
Development of Reverse Genetics Systems for Bluetongue Virus: Recovery of Infectious Virus from Synthetic RNA Transcripts
Mark Boyce, Cristina C. P. Celma, Polly Roy
Genome Replication and Regulation of Viral Gene Expression
Identification of a Second CtBP Binding Site in Adenovirus Type 5 E1A Conserved Region 3
Rachel K. Bruton, Peter Pelka, Katie L. Mapp, Gregory J. Fonseca, Joseph Torchia, Andrew S. Turnell, Joe S. Mymryk, Roger J. A. Grand
Genome Replication and Regulation of Viral Gene Expression
The Epstein-Barr Virus LF2 Protein Inhibits Viral Replication
Michael A. Calderwood, Amy M. Holthaus, Eric Johannsen
Genome Replication and Regulation of Viral Gene Expression
The Effects of Alternate Polypurine Tracts (PPTs) and Mutations of Sequences Adjacent to the PPT on Viral Replication and Cleavage Specificity of the Rous Sarcoma Virus Reverse Transcriptase
Kevin W. Chang, Jangsuk Oh, W. Gregory Alvord, Stephen H. Hughes
Genome Replication and Regulation of Viral Gene Expression
Structural Domains within the 3′ Untranslated Region of Turnip Crinkle Virus
John C. McCormack, Xuefeng Yuan, Yaroslava G. Yingling, Wojciech Kasprzak, Rodolfo E. Zamora, Bruce A. Shapiro, Anne E. Simon
Genome Replication and Regulation of Viral Gene Expression
Association of Hepatitis C Virus Replication Complexes with Microtubules and Actin Filaments Is Dependent on the Interaction of NS3 and NS5A
Chao-Kuen Lai, King-Song Jeng, Keigo Machida, Michael M. C. Lai
Genome Replication and Regulation of Viral Gene Expression
Translation Termination Reinitiation between Open Reading Frame 1 (ORF1) and ORF2 Enables Capsid Expression in a Bovine Norovirus without the Need for Production of Viral Subgenomic RNA
Christopher J. McCormick, Omar Salim, Paul R. Lambden, Ian N. Clarke
Genome Replication and Regulation of Viral Gene Expression
The Enhanced DNA Replication Fidelity of a Mutant Herpes Simplex Virus Type 1 DNA Polymerase Is Mediated by an Improved Nucleotide Selectivity and Reduced Mismatch Extension Ability
Wang Tian, Ying T. Hwang, Charles B. C. Hwang

Vaccines and Antiviral Agents

Vaccines and Antiviral Agents
A Replication-Competent, Neuronal Spread-Defective, Live Attenuated Herpes Simplex Virus Type 1 Vaccine
Elizabeth E. Brittle, Fushan Wang, John M. Lubinski, Ralph M. Bunte, Harvey M. Friedman
Vaccines and Antiviral Agents
Influenza Virus Protecting RNA: an Effective Prophylactic and Therapeutic Antiviral
Nigel J. Dimmock, Edward W. Rainsford, Paul D. Scott, Anthony C. Marriott
Vaccines and Antiviral Agents
Magnitude and Quality of Vaccine-Elicited T-Cell Responses in the Control of Immunodeficiency Virus Replication in Rhesus Monkeys
Yue Sun, Sampa Santra, Jörn E. Schmitz, Mario Roederer, Norman L. Letvin
Vaccines and Antiviral Agents
Impact of Exogenous Sequences on the Characteristics of an Epidemic Type 2 Recombinant Vaccine-Derived Poliovirus
Franck B. Riquet, Claire Blanchard, Sophie Jegouic, Jean Balanant, Sophie Guillot, Marie-Anne Vibet, Mala Rakoto-Andrianarivelo, Francis Delpeyroux

Transformation and Oncogenesis

Transformation and Oncogenesis
Human T-Cell Leukemia Virus Type 1 Infection Leads to Arrest in the G₁ Phase of the Cell Cycle
Meihong Liu, Liangpeng Yang, Ling Zhang, Baoying Liu, Randall Merling, Zheng Xia, Chou-Zen Giam
Transformation and Oncogenesis
Small-Molecule Inhibitor Which Reactivates p53 in Human T-Cell Leukemia Virus Type 1-Transformed Cells
Kyung-Jin Jung, Arindam Dasgupta, Keven Huang, Soo-Jin Jeong, Cynthia Pise-Masison, Katerina V. Gurova, John N. Brady
Transformation and Oncogenesis
Ras Modifies Proliferation and Invasiveness of Cells Expressing Human Papillomavirus Oncoproteins
Satoshi Yoshida, Naoko Kajitani, Ayano Satsuka, Hiroyasu Nakamura, Hiroyuki Sakai

Genetic Diversity and Evolution

Genetic Diversity and Evolution
Conserved Footprints of APOBEC3G on Hypermutated Human Immunodeficiency Virus Type 1 and Human Endogenous Retrovirus HERV-K(HML2) Sequences
Andrew E. Armitage, Aris Katzourakis, Tulio de Oliveira, John J. Welch, Robert Belshaw, Kate N. Bishop, Beatrice Kramer, Andrew J. McMichael, Andrew Rambaut, Astrid K. N. Iversen
Genetic Diversity and Evolution
Hypermutation of an Ancient Human Retrovirus by APOBEC3G
Young Nam Lee, Michael H. Malim, Paul D. Bieniasz
Genetic Diversity and Evolution
Anomalies in the Influenza Virus Genome Database: New Biology or Laboratory Errors?
Michael Krasnitz, Arnold J. Levine, Raul Rabadan

Letters to the Editor

LETTER TO THE EDITOR | Letter to the Editor | Letters to the Editor
Human B19 Erythrovirus In Vitro Replication: What's New?
Sylvie Pillet, Serge Fichelson, Frédéric Morinet

Errata

ERRATUM | Erratum | Errata
The Proline-Rich Homeodomain (PRH/HEX) Protein Is Down-Regulated in Liver during Infection with Lymphocytic Choriomeningitis Virus
Mahmoud Djavani, Ivan Topisirovic, Juan Carlos Zapata, Mariola Sadowska, Yida Yang, Juan Rodas, Igor S. Lukashevich, Clifford W. Bogue, C. David Pauza, Katherine L. B. Borden, Maria S. Salvato

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Table of Contents

Spotlight

Minireviews

Structure and Assembly

Cellular Response to Infection

Virus-Cell Interactions

Pathogenesis and Immunity

Genome Replication and Regulation of Viral Gene Expression

Vaccines and Antiviral Agents

Transformation and Oncogenesis

Genetic Diversity and Evolution

Letters to the Editor

Errata

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