Journal of Virology: 82 (15)

August 1, 2008; Volume 82,Issue 15

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Articles of Significant Interest Selected from This Issue by the Editors

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Intrinsic Structural Disorder in Adenovirus E1A: a Viral Molecular Hub Linking Multiple Diverse Processes
Peter Pelka, Jailal N. G. Ablack, Gregory J. Fonseca, Ahmed F. Yousef, Joe S. Mymryk

Pathogenesis and Immunity

Pathogenesis and Immunity
Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2
Jason Netland, David K. Meyerholz, Steven Moore, Martin Cassell, Stanley Perlman
Pathogenesis and Immunity
Limited Maintenance of Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8 T-Cell Receptor Clonotypes after Virus Challenge
Miranda Z. Smith, Tedi E. Asher, Vanessa Venturi, Miles P. Davenport, Daniel C. Douek, David A. Price, Stephen J. Kent
Pathogenesis and Immunity
Transmission of Human Immunodeficiency Virus Type 1 from a Patient Who Developed AIDS to an Elite Suppressor
Justin R. Bailey, Karen O'Connell, Hung-Chih Yang, Yefei Han, Jie Xu, Benjamin Jilek, Thomas M. Williams, Stuart C. Ray, Robert F. Siliciano, Joel N. Blankson
Pathogenesis and Immunity
A Bovine Herpesvirus Type 1 Mutant Virus Specifying a Carboxyl-Terminal Truncation of Glycoprotein E Is Defective in Anterograde Neuronal Transport in Rabbits and Calves
Z. F. Liu, M. C. S. Brum, A. Doster, C. Jones, S. I. Chowdhury
Pathogenesis and Immunity
Reovirus Serotypes Elicit Distinctive Patterns of Recall Immunity in Humans
Renée N. Douville, Ruey-Chyi Su, Kevin M. Coombs, F. Estelle R. Simons, Kent T. HayGlass
Pathogenesis and Immunity
Differences in Hepatitis C Virus (HCV)-Specific CD8 T-Cell Phenotype during Pegylated Alpha Interferon and Ribavirin Treatment Are Related to Response to Antiviral Therapy in Patients Chronically Infected with HCV
Joana Caetano, António Martinho, Artur Paiva, Beatriz Pais, Cristina Valente, Cristina Luxo
Pathogenesis and Immunity
Role of Interferon in Homologous and Heterologous Rotavirus Infection in the Intestines and Extraintestinal Organs of Suckling Mice
N. Feng, B. Kim, M. Fenaux, H. Nguyen, P. Vo, M. B. Omary, H. B. Greenberg
Pathogenesis and Immunity
Human Immunodeficiency Virus Type 1 Infection Increases the In Vivo Capacity of Peripheral Monocytes To Cross the Blood-Brain Barrier into the Brain and the In Vivo Sensitivity of the Blood-Brain Barrier to Disruption by Lipopolysaccharide
Hongwei Wang, Jinglin Sun, Harris Goldstein
Pathogenesis and Immunity
Dysregulation of TLR3 Impairs the Innate Immune Response to West Nile Virus in the Elderly
Kok-Fai Kong, Karine Delroux, Xiaomei Wang, Feng Qian, Alvaro Arjona, Stephen E. Malawista, Erol Fikrig, Ruth R. Montgomery
Pathogenesis and Immunity
Dengue Virus Replicon Expressing the Nonstructural Proteins Suffices To Enhance Membrane Expression of HLA Class I and Inhibit Lysis by Human NK Cells
Oren Hershkovitz, Alon Zilka, Ahuva Bar-Ilan, Shai Abutbul, Andrew Davidson, Michela Mazzon, Beate M. Kümmerer, Alon Monsoengo, Michael Jacobs, Angel Porgador
Pathogenesis and Immunity
Induction of Plasma (TRAIL), TNFR-2, Fas Ligand, and Plasma Microparticles after Human Immunodeficiency Virus Type 1 (HIV-1) Transmission: Implications for HIV-1 Vaccine Design
Nancy Gasper-Smith, Deanna M. Crossman, John F. Whitesides, Nadia Mensali, Janet S. Ottinger, Steven G. Plonk, M. Anthony Moody, Guido Ferrari, Kent J. Weinhold, Sara E. Miller, Charles F. Reich, Li Qin, Stephen G. Self, George M. Shaw, Thomas N. Denny, Laura E. Jones, David S. Pisetsky, Barton F. Haynes
Pathogenesis and Immunity
A Live Attenuated Severe Acute Respiratory Syndrome Coronavirus Is Immunogenic and Efficacious in Golden Syrian Hamsters
Elaine W. Lamirande, Marta L. DeDiego, Anjeanette Roberts, Jadon P. Jackson, Enrique Alvarez, Tim Sheahan, Wun-Ju Shieh, Sherif R. Zaki, Ralph Baric, Luis Enjuanes, Kanta Subbarao
Pathogenesis and Immunity
A Single Amino Acid Substitution in the Murine Norovirus Capsid Protein Is Sufficient for Attenuation In Vivo
D. Bailey, L. B. Thackray, I. G. Goodfellow

Virus-Cell Interactions

Virus-Cell Interactions
Primary Human Hepatocytes Are Susceptible to Infection by Hepatitis Delta Virus Assembled with Envelope Proteins of Woodchuck Hepatitis Virus
Severin Gudima, Yiping He, Ning Chai, Volker Bruss, Stephan Urban, William Mason, John Taylor
Virus-Cell Interactions
Transcription Factor YY1 and Its Associated Acetyltransferases CBP and p300 Interact with Hepatitis Delta Antigens and Modulate Hepatitis Delta Virus RNA Replication
Wen-Hung Huang, Ru-Tsun Mai, Yan-Hwa Wu Lee
Virus-Cell Interactions
UL36p Is Required for Efficient Transport of Membrane-Associated Herpes Simplex Virus Type 1 along Microtubules
Sara K. Shanda, Duncan W. Wilson
Virus-Cell Interactions
Early Increases in Superantigen-Specific Foxp3⁺ Regulatory T Cells during Mouse Mammary Tumor Virus Infection
Gabriel Cabrera, Dalia Burzyn, Juliana Mundiñano, M. Cecilia Courreges, Gabriela Camicia, Daniela Lorenzo, Héctor Costa, Susan R. Ross, Irene Nepomnaschy, Isabel Piazzon
Virus-Cell Interactions
Suppression of Astrovirus Replication by an ERK1/2 Inhibitor
Lindsey A. Moser, Stacey Schultz-Cherry
Virus-Cell Interactions
Identification of Residues outside of the Receptor Binding Domain That Influence the Infectivity and Tropism of Porcine Endogenous Retrovirus
Takele Argaw, Mariel Figueroa, Daniel R. Salomon, Carolyn A. Wilson
Virus-Cell Interactions
Reactive-Site Cleavage Residues Confer Target Specificity to Baculovirus P49, a Dimeric Member of the P35 Family of Caspase Inhibitors
Michael P. Guy, Paul D. Friesen
Virus-Cell Interactions
Asparagine 631 Variants of the Chicken Mx Protein Do Not Inhibit Influenza Virus Replication in Primary Chicken Embryo Fibroblasts or In Vitro Surrogate Assays
Camilla T. O. Benfield, Jon W. Lyall, Georg Kochs, Laurence S. Tiley
Virus-Cell Interactions
A Role for E1B-AP5 in ATR Signaling Pathways during Adenovirus Infection
Andrew N. Blackford, Rachel K. Bruton, Orkide Dirlik, Grant S. Stewart, A. Malcolm R. Taylor, Thomas Dobner, Roger J. A. Grand, Andrew S. Turnell
Virus-Cell Interactions
Different Mechanisms of Cell Entry by Human-Pathogenic Old World and New World Arenaviruses
Jillian M. Rojek, Ana B. Sanchez, Ngoc Thao Nguyen, Juan-Carlos de la Torre, Stefan Kunz
Virus-Cell Interactions
Establishment of B-Cell Lines Latently Infected with Reactivation-Competent Murine Gammaherpesvirus 68 Provides Evidence for Viral Alteration of a DNA Damage-Signaling Cascade
J. Craig Forrest, Samuel H. Speck
Virus-Cell Interactions
Critical Role of p53 in Histone Deacetylase Inhibitor-Induced Epstein-Barr Virus Zta Expression
Shih-Shin Chang, You-Chang Lo, Huey-Huey Chua, Hsin-Yi Chiu, Shu-Chun Tsai, Jen-Yang Chen, Kwok-Wai Lo, Ching-Hwa Tsai

Genome Replication and Regulation of Viral Gene Expression

Genome Replication and Regulation of Viral Gene Expression
Role for Conserved Residues of Sindbis Virus Nonstructural Protein 2 Methyltransferase-Like Domain in Regulation of Minus-Strand Synthesis and Development of Cytopathic Infection
Mayuri, Todd W. Geders, Janet L. Smith, Richard J. Kuhn
Genome Replication and Regulation of Viral Gene Expression
Dimerization of the Papillomavirus E2 Protein Is Required for Efficient Mitotic Chromosome Association and Brd4 Binding
Juan Cardenas-Mora, Jonathan E. Spindler, Moon Kyoo Jang, Alison A. McBride
Genome Replication and Regulation of Viral Gene Expression
Identification of Closely Spaced but Distinct Transcription Initiation Sites for the Murine Gammaherpesvirus 68 Latency-Associated M2 Gene
Mark DeZalia, Samuel H. Speck
Genome Replication and Regulation of Viral Gene Expression
Herpes Simplex Virus Type 1 ICP27 Regulates Expression of a Variant, Secreted Form of Glycoprotein C by an Intron Retention Mechanism
Lenka Sedlackova, Keith D. Perkins, Joy Lengyel, Anna K. Strain, Vicky L. van Santen, Stephen A. Rice
Genome Replication and Regulation of Viral Gene Expression
Repeated Passage of Wild-Type Woodchuck Hepatitis Virus in Lymphoid Cells Does Not Generate Cell Type-Specific Variants or Alter Virus Infectivity
Patricia M. Mulrooney-Cousins, Tomasz I. Michalak
Genome Replication and Regulation of Viral Gene Expression
Mutational Analysis of Plant Cap-Binding Protein eIF4E Reveals Key Amino Acids Involved in Biochemical Functions and Potyvirus Infection
Sylvie German-Retana, Jocelyne Walter, Bénédicte Doublet, Geneviève Roudet-Tavert, Valérie Nicaise, Cécile Lecampion, Marie-Christine Houvenaghel, Christophe Robaglia, Thierry Michon, Olivier Le Gall
Genome Replication and Regulation of Viral Gene Expression
Varicella-Zoster Virus Open Reading Frame 66 Protein Kinase Is Required for Efficient Viral Growth in Primary Human Corneal Stromal Fibroblast Cells
Angela Erazo, Michael B. Yee, Nikolaus Osterrieder, Paul R. Kinchington
Genome Replication and Regulation of Viral Gene Expression
Compensatory Role of Human Immunodeficiency Virus Central Polypurine Tract Sequence in Kinetically Disrupted Reverse Transcription
Mark Skasko, Baek Kim
Genome Replication and Regulation of Viral Gene Expression
Formation of Guanosine(5′)Tetraphospho(5′)Adenosine Cap Structure by an Unconventional mRNA Capping Enzyme of Vesicular Stomatitis Virus
Tomoaki Ogino, Amiya K. Banerjee
Genome Replication and Regulation of Viral Gene Expression
Vpx Is Critical for Reverse Transcription of the Human Immunodeficiency Virus Type 2 Genome in Macrophages
Mikako Fujita, Masami Otsuka, Masami Miyoshi, Boonruang Khamsri, Masako Nomaguchi, Akio Adachi

Structure and Assembly

Structure and Assembly
Visualization of the Externalized VP2 N Termini of Infectious Human Parvovirus B19
Bärbel Kaufmann, Paul R. Chipman, Victor A. Kostyuchenko, Susanne Modrow, Michael G. Rossmann
Structure and Assembly
Cryoelectron Microscopy Map of Atadenovirus Reveals Cross-Genus Structural Differences from Human Adenovirus
Radosav S. Pantelic, Linda J. Lockett, Rosalba Rothnagel, Ben Hankamer, Gerald W. Both
Structure and Assembly
Atomic Force Microscopy Investigation of Vaccinia Virus Structure
Y. Kuznetsov, P. D. Gershon, A. McPherson
Structure and Assembly
NS3 Helicase Domains Involved in Infectious Intracellular Hepatitis C Virus Particle Assembly
Yinghong Ma, Jeremy Yates, Yuqiong Liang, Stanley M. Lemon, MinKyung Yi

Cellular Response to Infection

Cellular Response to Infection
Cellular Proteins PML and Daxx Mediate an Innate Antiviral Defense Antagonized by the Adenovirus E4 ORF3 Protein
Amanda J. Ullman, Patrick Hearing
Cellular Response to Infection
Recombinant Adeno-Associated Viral Vectors Are Deficient in Provoking a DNA Damage Response
Michalis Fragkos, Madlaina Breuleux, Nathalie Clément, Peter Beard

Genetic Diversity and Evolution

Genetic Diversity and Evolution
Genetic Analysis of the Capsid Gene of Genotype GII.2 Noroviruses
Nobuhiro Iritani, Harry Vennema, J. Joukje Siebenga, Roland J. Siezen, Bernadet Renckens, Yoshiyuki Seto, Atsushi Kaida, Marion Koopmans
Genetic Diversity and Evolution
Investigation of Putative Multisubtype Hepatitis C Virus Infections In Vivo by Heteroduplex Mobility Analysis of Core/Envelope Subgenomes
Hui Li, Lisa V. Thomassen, Ayaz Majid, Brian J. McMahon, Dana Bruden, Susan McArdle, Nazneen Bano, Minjun Chung, Robert L. Carithers, James D. Perkins, Daniel G. Sullivan, David R. Gretch
Genetic Diversity and Evolution
Interspecies Transmission of Simian Foamy Virus in a Natural Predator-Prey System
Fabian H. Leendertz, Florian Zirkel, Emmanuel Couacy-Hymann, Heinz Ellerbrok, Vladimir A. Morozov, Georg Pauli, Claudia Hedemann, Pierre Formenty, Siv Aina Jensen, Christophe Boesch, Sandra Junglen

Vaccines and Antiviral Agents

Vaccines and Antiviral Agents
Improved Induction of Antibodies against Key Neutralizing Epitopes by Human Immunodeficiency Virus Type 1 gp120 DNA Prime-Protein Boost Vaccination Compared to gp120 Protein-Only Vaccination
Michael Vaine, Shixia Wang, Emma T. Crooks, Pengfei Jiang, David C. Montefiori, James Binley, Shan Lu
Vaccines and Antiviral Agents
Reduction in Severity of a Herpes Simplex Virus Type 1 Murine Infection by Treatment with a Ribozyme Targeting the U_L20 Gene RNA
Jia Liu, Alfred S. Lewin, Sonal S. Tuli, Steven C. Ghivizzani, Gregory S. Schultz, David C. Bloom
Vaccines and Antiviral Agents
Induction of Broad CD4⁺ and CD8⁺ T-Cell Responses and Cross- Neutralizing Antibodies against Hepatitis C Virus by Vaccination with Th1-Adjuvanted Polypeptides Followed by Defective Alphaviral Particles Expressing Envelope Glycoproteins gpE1 and gpE2 and Nonstructural Proteins 3, 4, and 5
Yinling Lin, Taewoo Kwon, John Polo, Yi-Fei Zhu, Stephen Coates, Kevin Crawford, Christine Dong, Mark Wininger, John Hall, Mark Selby, Doris Coit, Angelica Medina-Selby, Colin McCoin, Philip Ng, Debbie Drane, David Chien, Jang Han, Michael Vajdy, Michael Houghton
Vaccines and Antiviral Agents
Mechanistic Studies of a T20-Dependent Human Immunodeficiency Virus Type 1 Variant
Chris Baldwin, Ben Berkhout

Transformation and Oncogenesis

Transformation and Oncogenesis
Differential Gene Regulation by Epstein-Barr Virus Type 1 and Type 2 EBNA2
Walter Lucchesi, Gareth Brady, Oliver Dittrich-Breiholz, Michael Kracht, Rainer Russ, Paul J. Farrell

Gene Delivery

Gene Delivery
Biodistribution and Safety Profile of Recombinant Adeno-Associated Virus Serotype 6 Vectors following Intravenous Delivery
Daniel Stone, Ying Liu, Zong-Yi Li, Robert Strauss, Eric E. Finn, James M. Allen, Jeffrey S. Chamberlain, André Lieber

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Table of Contents

Spotlight

Minireviews

Pathogenesis and Immunity

Virus-Cell Interactions

Genome Replication and Regulation of Viral Gene Expression

Structure and Assembly

Cellular Response to Infection

Genetic Diversity and Evolution

Vaccines and Antiviral Agents

Transformation and Oncogenesis

Gene Delivery

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