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Virus-Cell Interactions

Proteolytic Processing of the Ebola Virus Glycoprotein Is Not Critical for Ebola Virus Replication in Nonhuman Primates

Gabriele Neumann, Thomas W. Geisbert, Hideki Ebihara, Joan B. Geisbert, Kathleen M. Daddario-DiCaprio, Heinz Feldmann, Yoshihiro Kawaoka
Gabriele Neumann
1Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin
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Thomas W. Geisbert
2United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland
3Uniformed Services University of the Health Sciences, Bethesda, Maryland
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Hideki Ebihara
4Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, and Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
5Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
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Joan B. Geisbert
2United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland
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Kathleen M. Daddario-DiCaprio
2United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland
3Uniformed Services University of the Health Sciences, Bethesda, Maryland
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Heinz Feldmann
4Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, and Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
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Yoshihiro Kawaoka
1Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin
5Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
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  • For correspondence: kawaokay@svm.vetmed.wisc.edu
DOI: 10.1128/JVI.02486-06
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ABSTRACT

Enveloped viruses often require cleavage of a surface glycoprotein by a cellular endoprotease such as furin for infectivity and virulence. Previously, we showed that Ebola virus glycoprotein does not require the furin cleavage motif for virus replication in cell culture. Here, we show that there are no appreciable differences in disease progression, hematology, serum biochemistry, virus titers, or lethality in nonhuman primates infected with an Ebola virus lacking the furin recognition sequence compared to those infected with wild-type virus. We conclude that glycoprotein cleavage by subtilisin-like endoproteases is not critical for Ebola virus infectivity and virulence in nonhuman primates.

  • Copyright © 2007 American Society for Microbiology
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Proteolytic Processing of the Ebola Virus Glycoprotein Is Not Critical for Ebola Virus Replication in Nonhuman Primates
Gabriele Neumann, Thomas W. Geisbert, Hideki Ebihara, Joan B. Geisbert, Kathleen M. Daddario-DiCaprio, Heinz Feldmann, Yoshihiro Kawaoka
Journal of Virology Feb 2007, 81 (6) 2995-2998; DOI: 10.1128/JVI.02486-06

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Proteolytic Processing of the Ebola Virus Glycoprotein Is Not Critical for Ebola Virus Replication in Nonhuman Primates
Gabriele Neumann, Thomas W. Geisbert, Hideki Ebihara, Joan B. Geisbert, Kathleen M. Daddario-DiCaprio, Heinz Feldmann, Yoshihiro Kawaoka
Journal of Virology Feb 2007, 81 (6) 2995-2998; DOI: 10.1128/JVI.02486-06
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KEYWORDS

ebolavirus
Protein Processing, Post-Translational
Viral Envelope Proteins
virus replication

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