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Genetic Diversity and Evolution

Comparison of the Mutation Rates of Human Influenza A and B Viruses

Eri Nobusawa, Katsuhiko Sato
Eri Nobusawa
1Department of Microbiology and Infection, Nagoya City University Graduate School of Medical Science
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  • For correspondence: nobusawa@med.nagoya-cu.ac.jp
Katsuhiko Sato
2Department of Microbiology, Aichi Prefectural Institute of Public Health, Nagoya City, Japan
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DOI: 10.1128/JVI.80.7.3675-3678.2006
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ABSTRACT

Human influenza A viruses evolve more rapidly than influenza B viruses. To clarify the cause of this difference, we have evaluated the mutation rate of the nonstructural gene as revealed by the genetic diversity observed during the growth of individual plaques in MDCK cells. Six plaques were studied, representing two strains each of type A and B viruses. A total of 813,663 nucleotides were sequenced, giving rates of 2.0 × 10−6 and 0.6 × 10−6 mutations per site per infectious cycle, which, when extended to 1 year, agree well with the published annual evolutionary rates.

  • Copyright © 2006 American Society for Microbiology
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Comparison of the Mutation Rates of Human Influenza A and B Viruses
Eri Nobusawa, Katsuhiko Sato
Journal of Virology Mar 2006, 80 (7) 3675-3678; DOI: 10.1128/JVI.80.7.3675-3678.2006

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Comparison of the Mutation Rates of Human Influenza A and B Viruses
Eri Nobusawa, Katsuhiko Sato
Journal of Virology Mar 2006, 80 (7) 3675-3678; DOI: 10.1128/JVI.80.7.3675-3678.2006
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KEYWORDS

influenza A virus
influenza B virus
mutation

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