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Pathogenesis and Immunity

Replication of Hepatitis C Virus (HCV) RNA in Mouse Embryonic Fibroblasts: Protein Kinase R (PKR)-Dependent and PKR-Independent Mechanisms for Controlling HCV RNA Replication and Mediating Interferon Activities

Kyung-Soo Chang, Zhaohui Cai, Chen Zhang, Ganes C. Sen, Bryan R. G. Williams, Guangxiang Luo
Kyung-Soo Chang
1Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, 800 Rose Street, Lexington, Kentucky 40536-0298
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Zhaohui Cai
1Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, 800 Rose Street, Lexington, Kentucky 40536-0298
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Chen Zhang
1Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, 800 Rose Street, Lexington, Kentucky 40536-0298
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Ganes C. Sen
2Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195
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Bryan R. G. Williams
2Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195
3Monash Institute of Medical Research, Monash University, Melbourne, Australia
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Guangxiang Luo
1Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, 800 Rose Street, Lexington, Kentucky 40536-0298
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  • For correspondence: gluo0@uky.edu
DOI: 10.1128/JVI.00586-06
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Article Information

DOI 
https://doi.org/10.1128/JVI.00586-06
PubMed 
16840317

Published By 
American Society for Microbiology Journals
History 
  • Received March 23, 2006
  • Accepted May 9, 2006
  • Published online July 12, 2006.

Copyright & Usage 
Copyright © 2006 American Society for Microbiology

Author Information

  1. Kyung-Soo Chang1,
  2. Zhaohui Cai1,
  3. Chen Zhang1,
  4. Ganes C. Sen2,
  5. Bryan R. G. Williams2,3 and
  6. Guangxiang Luo1*
  1. 1Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, 800 Rose Street, Lexington, Kentucky 40536-0298
  2. 2Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195
  3. 3Monash Institute of Medical Research, Monash University, Melbourne, Australia
  • ↵* Corresponding author. Mailing address: Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, 800 Rose St., Lexington, KY 40536-0298. Phone: (859) 257-5577. Fax: (859) 257-8994. E-mail: gluo0{at}uky.edu .

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Replication of Hepatitis C Virus (HCV) RNA in Mouse Embryonic Fibroblasts: Protein Kinase R (PKR)-Dependent and PKR-Independent Mechanisms for Controlling HCV RNA Replication and Mediating Interferon Activities
Kyung-Soo Chang, Zhaohui Cai, Chen Zhang, Ganes C. Sen, Bryan R. G. Williams, Guangxiang Luo
Journal of Virology Jul 2006, 80 (15) 7364-7374; DOI: 10.1128/JVI.00586-06

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Replication of Hepatitis C Virus (HCV) RNA in Mouse Embryonic Fibroblasts: Protein Kinase R (PKR)-Dependent and PKR-Independent Mechanisms for Controlling HCV RNA Replication and Mediating Interferon Activities
Kyung-Soo Chang, Zhaohui Cai, Chen Zhang, Ganes C. Sen, Bryan R. G. Williams, Guangxiang Luo
Journal of Virology Jul 2006, 80 (15) 7364-7374; DOI: 10.1128/JVI.00586-06
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KEYWORDS

hepacivirus
Interferon-alpha
Interferon-beta
RNA, Viral
virus replication
eIF-2 Kinase

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