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Pathogenesis and Immunity

Isolation and Characterization of Human Monoclonal Antibodies from Individuals Infected with West Nile Virus

Mark Throsby, Cecile Geuijen, Jaap Goudsmit, Arjen Q. Bakker, Jehanara Korimbocus, R. Arjen Kramer, Marieke Clijsters-van der Horst, Maureen de Jong, Mandy Jongeneelen, Sandra Thijsse, Renate Smit, Therese J. Visser, Nora Bijl, Wilfred E. Marissen, Mark Loeb, David J. Kelvin, Wolfgang Preiser, Jan ter Meulen, John de Kruif
Mark Throsby
1Crucell Holland B.V., Leiden, The Netherlands
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  • For correspondence: m.throsby@crucell.com
Cecile Geuijen
1Crucell Holland B.V., Leiden, The Netherlands
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Jaap Goudsmit
1Crucell Holland B.V., Leiden, The Netherlands
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Arjen Q. Bakker
1Crucell Holland B.V., Leiden, The Netherlands
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Jehanara Korimbocus
2National Reference Center for Arbovirus and Viral Hemorrhagic Fevers, Pasteur Institute, Lyon, France
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R. Arjen Kramer
1Crucell Holland B.V., Leiden, The Netherlands
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Marieke Clijsters-van der Horst
1Crucell Holland B.V., Leiden, The Netherlands
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Maureen de Jong
1Crucell Holland B.V., Leiden, The Netherlands
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Mandy Jongeneelen
1Crucell Holland B.V., Leiden, The Netherlands
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Sandra Thijsse
1Crucell Holland B.V., Leiden, The Netherlands
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Renate Smit
1Crucell Holland B.V., Leiden, The Netherlands
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Therese J. Visser
1Crucell Holland B.V., Leiden, The Netherlands
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Nora Bijl
1Crucell Holland B.V., Leiden, The Netherlands
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Wilfred E. Marissen
1Crucell Holland B.V., Leiden, The Netherlands
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Mark Loeb
3Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
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David J. Kelvin
4Division of Experimental Therapeutics, University Health Network, Toronto, Canada
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Wolfgang Preiser
5Institute of Medical Virology, W. Goethe-Universität, Frankfurt, Germany
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Jan ter Meulen
1Crucell Holland B.V., Leiden, The Netherlands
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John de Kruif
1Crucell Holland B.V., Leiden, The Netherlands
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DOI: 10.1128/JVI.00551-06
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Article Information

DOI 
https://doi.org/10.1128/JVI.00551-06
PubMed 
16809304

Published By 
American Society for Microbiology Journals
History 
  • Received March 16, 2006
  • Accepted April 21, 2006
  • Published online June 28, 2006.

Copyright & Usage 
Copyright © 2006 American Society for Microbiology

Author Information

  1. Mark Throsby1*,
  2. Cecile Geuijen1,
  3. Jaap Goudsmit1,
  4. Arjen Q. Bakker1,
  5. Jehanara Korimbocus2,
  6. R. Arjen Kramer1,
  7. Marieke Clijsters-van der Horst1,
  8. Maureen de Jong1,
  9. Mandy Jongeneelen1,
  10. Sandra Thijsse1,
  11. Renate Smit1,
  12. Therese J. Visser1,
  13. Nora Bijl1†,
  14. Wilfred E. Marissen1,
  15. Mark Loeb3,
  16. David J. Kelvin4,
  17. Wolfgang Preiser5‡,
  18. Jan ter Meulen1 and
  19. John de Kruif1
  1. 1Crucell Holland B.V., Leiden, The Netherlands
  2. 2National Reference Center for Arbovirus and Viral Hemorrhagic Fevers, Pasteur Institute, Lyon, France
  3. 3Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
  4. 4Division of Experimental Therapeutics, University Health Network, Toronto, Canada
  5. 5Institute of Medical Virology, W. Goethe-Universität, Frankfurt, Germany
  • ↵* Corresponding author. Mailing address: Crucell Holland B.V., P.O. Box 2048, 2301 CA, Leiden, The Netherlands. Phone: 31 (71) 5248778. Fax: 31 (71) 5248702. E-mail: m.throsby{at}crucell.com .
  • ↵† Present address: Department of Medical Biochemistry, Academic Medical Centre, Amsterdam, The Netherlands.; ‡ Present address: Department of Pathology, University of Stellenbosch, Tygerberg, South Africa.

  • § Supplemental material for this article may be found at http://jvi.asm.org .

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Isolation and Characterization of Human Monoclonal Antibodies from Individuals Infected with West Nile Virus
Mark Throsby, Cecile Geuijen, Jaap Goudsmit, Arjen Q. Bakker, Jehanara Korimbocus, R. Arjen Kramer, Marieke Clijsters-van der Horst, Maureen de Jong, Mandy Jongeneelen, Sandra Thijsse, Renate Smit, Therese J. Visser, Nora Bijl, Wilfred E. Marissen, Mark Loeb, David J. Kelvin, Wolfgang Preiser, Jan ter Meulen, John de Kruif
Journal of Virology Jun 2006, 80 (14) 6982-6992; DOI: 10.1128/JVI.00551-06

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Isolation and Characterization of Human Monoclonal Antibodies from Individuals Infected with West Nile Virus
Mark Throsby, Cecile Geuijen, Jaap Goudsmit, Arjen Q. Bakker, Jehanara Korimbocus, R. Arjen Kramer, Marieke Clijsters-van der Horst, Maureen de Jong, Mandy Jongeneelen, Sandra Thijsse, Renate Smit, Therese J. Visser, Nora Bijl, Wilfred E. Marissen, Mark Loeb, David J. Kelvin, Wolfgang Preiser, Jan ter Meulen, John de Kruif
Journal of Virology Jun 2006, 80 (14) 6982-6992; DOI: 10.1128/JVI.00551-06
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KEYWORDS

Antibodies, Monoclonal
Antibodies, Viral
Viral Envelope Proteins
West Nile Fever
West Nile virus

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