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Pathogenesis and Immunity

Human Leukocyte Antigen B58 Supertype and Human Immunodeficiency Virus Type 1 Infection in Native Africans

Aleksandr Lazaryan, Elena Lobashevsky, Joseph Mulenga, Etienne Karita, Susan Allen, Jianming Tang, Richard A. Kaslow
Aleksandr Lazaryan
1Departments of Epidemiology
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Elena Lobashevsky
1Departments of Epidemiology
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Joseph Mulenga
4National Blood Transfusion Service, Lusaka, Zambia
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Etienne Karita
5Project San Francisco, Kigali, Rwanda
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Susan Allen
6Department of Global Health, Emory University, Atlanta, Georgia
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Jianming Tang
2Medicine
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Richard A. Kaslow
1Departments of Epidemiology
2Medicine
3Microbiology, University of Alabama at Birmingham, Birmingham, Alabama
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  • For correspondence: rkaslow@uab.edu
DOI: 10.1128/JVI.02119-05
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    FIG. 1.

    Viral load distribution of HLA-B58 supertype alleles in Zambians. Horizontal bars correspond to median viral loads. The P values were derived from the Mann-Whitney test, and only P values of <0.1 are shown.

  • FIG. 2.
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    FIG. 2.

    (a) Distribution of HLA-B58 supertype alleles within three VL categories in Zambians. The vertical bars represent the proportions of subjects with a particular B58s allele within each category. The number of subjects with a B58s allele is shown at the top of the bar for each category. P values were calculated with the Jonckheere-Terpstra test. (b) Distribution of HLA-B58 supertype alleles within three HIV-1 disease progression groups of Rwandans. The vertical bars represent the proportions of subjects with a B58s allele within each group. The number of subjects with a B58s allele is shown at the top of the bar for each category. P values were derived from the Jonckheere-Terpstra test.

Tables

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  • TABLE 1.

    Effects of HLA-B58s alleles on HIV-1 VL, stratified according to heterosexual HIV-1 transmission categories in Zambiansa

    HLA-B58s alleleSeroprevalent subjectsb (n = 276)Seroconvertersc (n = 147)Combined groups (n = 423)
    No.MeanΔVLdPNo.MeanΔVLPNo.MeanΔVLP
    B58s854.64−0.160.14424.47−0.080.591274.58−0.120.18
    B*5801274.49−0.280.06134.56+0.040.86404.52−0.160.23
    B*5802185.17+0.460.001144.74+0.240.28324.97+0.330.02
    B*5703354.5−0.280.07113.98−0.590.01464.36−0.340.01
    B*1516-*1517104.66−0.090.694—e——144.77+0.120.53
    • ↵ a All estimates are from the univariate GEE models.

    • ↵ b Seroprevalent subjects, seropositive index partners who were HIV-1 positive at the time of study entry.

    • ↵ c Seroconverters, partners of discordant couples who seroconverted during follow-up.

    • ↵ d ΔVL values correspond to beta coefficients from the GEE models.

    • ↵ e —, not reported due to instability of estimates.

  • TABLE 2.

    Linear associationa of HLA-B58s and HLA-C alleles with HIV-1 viral load in Zambians

    B58s and Cw alleles carried by groupMeanbΔVLcP
    B*5703-Cw*18 haplotype (n = 38)d4.24−0.47<0.001
    Cw*18+ B*5703+ (n = 38) vs. Cw*18+ B*5703− (n = 28)4.25−0.140.52
    Cw*18− B*5703+ (n = 8) vs. Cw*18− B*5703− (n = 348)5.0+0.270.31
    B*5703+ Cw*18+ (n = 38) vs. B*5703+ Cw*18− (n = 8)4.25−0.72<0.01
    B*5703− Cw*18+ (n = 28)f vs. B*5703− Cw*18− (n = 349)4.39−0.340.03
    B*5802-Cw*06 haplotype (n = 30)d4.95+0.310.03
    Cw*06+ B*5802+ (n = 30) vs. Cw*06+ B*5802− (n = 59)4.95+0.47<0.01
    Cw*06− B*5802+ (n = 2) vs. Cw*06− B*5802− (n = 332)—e——
    B*5802− Cw*06+ (n = 59) vs. B*5802− Cw*06− (n = 332)4.48−0.190.14
    B*5801-Cw*03 haplotype (n = 13)d4.18−0.50.05
    Cw*03+ B*5801+ (n = 13) vs. Cw*03+ B*5801− (n = 39)4.23−0.520.07
    Cw*03− B*5801+ (n = 27) vs. Cw*03− B*5801− (n = 344)4.68+0.010.92
    B*5801+ Cw*03+ (n = 13) vs. B*5801+ Cw*03− (n = 27)4.23−0.430.12
    B*5801− Cw*03+ (n = 39) vs. B*5801−Cw*03− (n = 344)4.75+0.080.61
    • ↵ a Assessed by GEE.

    • ↵ b Corresponds to mean log10 VL of haplotype or the first group of comparison strata.

    • ↵ c Corresponds to beta coefficients from the GEE models.

    • ↵ d Compared to the absence of haplotype.

    • ↵ e Not reported due to instability of estimates.

    • ↵ f Six Cw*18-positive subjects had lower VLs (mean = 4.4, Δlog10 VL = −0.33, P = 0.3) after exclusion of 22 B*8101-positive subjects

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Human Leukocyte Antigen B58 Supertype and Human Immunodeficiency Virus Type 1 Infection in Native Africans
Aleksandr Lazaryan, Elena Lobashevsky, Joseph Mulenga, Etienne Karita, Susan Allen, Jianming Tang, Richard A. Kaslow
Journal of Virology May 2006, 80 (12) 6056-6060; DOI: 10.1128/JVI.02119-05

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Human Leukocyte Antigen B58 Supertype and Human Immunodeficiency Virus Type 1 Infection in Native Africans
Aleksandr Lazaryan, Elena Lobashevsky, Joseph Mulenga, Etienne Karita, Susan Allen, Jianming Tang, Richard A. Kaslow
Journal of Virology May 2006, 80 (12) 6056-6060; DOI: 10.1128/JVI.02119-05
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KEYWORDS

HIV Infections
HIV-1
HLA-B Antigens

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