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Genome Replication and Regulation of Viral Gene Expression

High-Molecular-Weight Protein (pUL48) of Human Cytomegalovirus Is a Competent Deubiquitinating Protease: Mutant Viruses Altered in Its Active-Site Cysteine or Histidine Are Viable

Jianlei Wang, Amy N. Loveland, Lisa M. Kattenhorn, Hidde L. Ploegh, Wade Gibson
Jianlei Wang
1Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205
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Amy N. Loveland
1Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205
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Lisa M. Kattenhorn
2Whitehead Institute of Biomedical Research, Nine Cambridge Center, Room 361B, Cambridge, Massachusetts 02142
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Hidde L. Ploegh
2Whitehead Institute of Biomedical Research, Nine Cambridge Center, Room 361B, Cambridge, Massachusetts 02142
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Wade Gibson
1Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205
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  • For correspondence: wgibson@jhmi.edu
DOI: 10.1128/JVI.00401-06
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Article Information

DOI 
https://doi.org/10.1128/JVI.00401-06
PubMed 
16731939

Published By 
American Society for Microbiology Journals
History 
  • Received February 24, 2006
  • Accepted April 4, 2006
  • Published online May 26, 2006.

Copyright & Usage 
Copyright © 2006 American Society for Microbiology

Author Information

  1. Jianlei Wang1,
  2. Amy N. Loveland1,
  3. Lisa M. Kattenhorn2,
  4. Hidde L. Ploegh2 and
  5. Wade Gibson1*
  1. 1Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205
  2. 2Whitehead Institute of Biomedical Research, Nine Cambridge Center, Room 361B, Cambridge, Massachusetts 02142
  • ↵* Corresponding author. Mailing address: Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205. Phone: (410) 955-8680. Fax: (410) 955-3023. E-mail: wgibson{at}jhmi.edu .
  • † We dedicate this article to the memory of Cecile M. Pickart, a leading investigator of the structure and regulatory involvements of ubiquitin and a generous colleague.

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High-Molecular-Weight Protein (pUL48) of Human Cytomegalovirus Is a Competent Deubiquitinating Protease: Mutant Viruses Altered in Its Active-Site Cysteine or Histidine Are Viable
Jianlei Wang, Amy N. Loveland, Lisa M. Kattenhorn, Hidde L. Ploegh, Wade Gibson
Journal of Virology May 2006, 80 (12) 6003-6012; DOI: 10.1128/JVI.00401-06

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High-Molecular-Weight Protein (pUL48) of Human Cytomegalovirus Is a Competent Deubiquitinating Protease: Mutant Viruses Altered in Its Active-Site Cysteine or Histidine Are Viable
Jianlei Wang, Amy N. Loveland, Lisa M. Kattenhorn, Hidde L. Ploegh, Wade Gibson
Journal of Virology May 2006, 80 (12) 6003-6012; DOI: 10.1128/JVI.00401-06
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KEYWORDS

Cysteine Endopeptidases
cytomegalovirus
Viral Proteins

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