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Structure and Assembly

Viral RNA Is Required for the Association of APOBEC3G with Human Immunodeficiency Virus Type 1 Nucleoprotein Complexes

Mohammad A. Khan, Sandra Kao, Eri Miyagi, Hiroaki Takeuchi, Ritu Goila-Gaur, Sandrine Opi, Clay L. Gipson, Tristram G. Parslow, Hinh Ly, Klaus Strebel
Mohammad A. Khan
1Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892-0460
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Sandra Kao
1Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892-0460
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Eri Miyagi
1Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892-0460
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Hiroaki Takeuchi
1Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892-0460
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Ritu Goila-Gaur
1Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892-0460
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Sandrine Opi
1Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892-0460
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Clay L. Gipson
2Emory University, Department of Pathology and Laboratory Medicine, Experimental Pathology Division, Atlanta, Georgia 30322
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Tristram G. Parslow
2Emory University, Department of Pathology and Laboratory Medicine, Experimental Pathology Division, Atlanta, Georgia 30322
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Hinh Ly
2Emory University, Department of Pathology and Laboratory Medicine, Experimental Pathology Division, Atlanta, Georgia 30322
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Klaus Strebel
1Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892-0460
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  • For correspondence: kstrebel@nih.gov
DOI: 10.1128/JVI.79.9.5870-5874.2005
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ABSTRACT

APOBEC3G (APO3G) is a host cytidine deaminase that is incorporated into human immunodeficiency virus type 1 (HIV-1) particles. We report here that viral RNA promotes stable association of APO3G with HIV-1 nucleoprotein complexes (NPC). A target sequence located within the 5′-untranslated region of the HIV-1 RNA was identified to be necessary and sufficient for efficient APO3G packaging. Fine mapping revealed a sequence normally involved in viral genomic RNA dimerization and Gag binding to be important for APO3G packaging and association with viral NPC. Our data suggest that packaging of APO3G into HIV-1 NPC is enhanced by viral RNA.

  • Copyright © 2005 American Society for Microbiology
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Viral RNA Is Required for the Association of APOBEC3G with Human Immunodeficiency Virus Type 1 Nucleoprotein Complexes
Mohammad A. Khan, Sandra Kao, Eri Miyagi, Hiroaki Takeuchi, Ritu Goila-Gaur, Sandrine Opi, Clay L. Gipson, Tristram G. Parslow, Hinh Ly, Klaus Strebel
Journal of Virology Apr 2005, 79 (9) 5870-5874; DOI: 10.1128/JVI.79.9.5870-5874.2005

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Viral RNA Is Required for the Association of APOBEC3G with Human Immunodeficiency Virus Type 1 Nucleoprotein Complexes
Mohammad A. Khan, Sandra Kao, Eri Miyagi, Hiroaki Takeuchi, Ritu Goila-Gaur, Sandrine Opi, Clay L. Gipson, Tristram G. Parslow, Hinh Ly, Klaus Strebel
Journal of Virology Apr 2005, 79 (9) 5870-5874; DOI: 10.1128/JVI.79.9.5870-5874.2005
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KEYWORDS

HIV-1
Nucleoproteins
Proteins
RNA, Viral

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