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Pathogenesis and Immunity | Spotlight

Dengue Fever in Humanized NOD/SCID Mice

Dennis A. Bente, Michael W. Melkus, J. Victor Garcia, Rebeca Rico-Hesse
Dennis A. Bente
1Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, Texas 78227
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Michael W. Melkus
2University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, Texas 75390
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J. Victor Garcia
2University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, Texas 75390
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Rebeca Rico-Hesse
1Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, Texas 78227
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  • For correspondence: rricoh@sfbr.org
DOI: 10.1128/JVI.79.21.13797-13799.2005
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    FIG. 1.

    Signs of dengue virus infection in humanized NOD/SCID mice. (a) Thrombocytopenia and erythema in infected mice by day 8 (means and standard errors of the means); platelet levels in nonreconstituted, infected and noninfected (“normal”; n = 9) versus reconstituted, infected (n = 6); and erythema development in the latter group. O.D., optical density. (b) Viremia and fever on days 1 to 18 (mean and standard error) in mice reconstituted with human CD34+ cells. (c) Comparison of rashes on the backs of shaved mice. The nonreconstituted, infected mouse is on the left, and the reconstituted, infected mouse is on the right (both day 7 postinfection).

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    FIG. 2.

    Comparison of dengue virus RNA in reconstituted, infected NOD/SCID mice (hu-SCID) and nonreconstituted, infected NOD/SCID mice (SCID) on day 8. Virus positive-strand RNA was estimated in each organ (samples in triplicate), using quantitative, real-time RT-PCR, as described in reference 3. The dotted line reflects the limit of detection: approximately 60 genome equivalents per organ sample.

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Dengue Fever in Humanized NOD/SCID Mice
Dennis A. Bente, Michael W. Melkus, J. Victor Garcia, Rebeca Rico-Hesse
Journal of Virology Oct 2005, 79 (21) 13797-13799; DOI: 10.1128/JVI.79.21.13797-13799.2005

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Dengue Fever in Humanized NOD/SCID Mice
Dennis A. Bente, Michael W. Melkus, J. Victor Garcia, Rebeca Rico-Hesse
Journal of Virology Oct 2005, 79 (21) 13797-13799; DOI: 10.1128/JVI.79.21.13797-13799.2005
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KEYWORDS

dengue
dengue virus
Disease Models, Animal
Hematopoietic Stem Cell Transplantation

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