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TABLE 1.

Published 31 December 1969
TABLE 1.

Estimates of the HIV-1 in vivo effective population sizea

Study (references)Patient groupPopulationGene(s)Ne
Leigh Brown (22)UntreatedFree virus env 1,000-2,100
Nijhuis et al. (31)Before and during therapyFree virus env 450-16,000
Rodrigo et al. (37)Before and during therapyProvirus env 925-1,800
Rouzine and Coffin (38)Untreated and on therapyFree virus/provirus pro 100,000
Seo et al. (39)Untreated and on therapyFree virus/provirus env 1,500-5,500
Shriner et al. (40)Untreated and on therapyFree virus/provirus env 1,000
Achaz et al. (1)UntreatedFree virus gag-pol 1,000-10,000
  • ↵ a Seven different studies estimate Ne between 500 and 105. Shriner et al. (40) show that the high number estimated by Rouzine and Coffin (38) decreases to aproximately 103 upon correcting for a biased sampling procedure. Therefore, the effective population size is probably between 103 and 104. Untreated patients show similar numbers to patients on therapy. Similar results were obtained by measuring plasma viral RNA or cell-associated viral DNA. Although different selection pressures act on env and gag-pol, it is interesting to note that similar estimates of Ne have been found based on data for both genes.

Vol 95 Issue 9 Table of Contents
Journal of Virology: 95 (9)

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