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Vaccines and Antiviral Agents

Novel Adeno-Associated Virus Vector Vaccine Restricts Replication of Simian Immunodeficiency Virus in Macaques

Philip R. Johnson, Bruce C. Schnepp, Mary J. Connell, Daniela Rohne, Suzanne Robinson, Georgia R. Krivulka, Carol I. Lord, Rebekah Zinn, David C. Montefiori, Norman L. Letvin, K. Reed Clark
Philip R. Johnson
1Center for Gene Therapy, Columbus Children's Research Institute, Columbus Children's Hospital, and Department of Pediatrics, College of Medicine and Public Health, Ohio State University, Columbus, Ohio
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  • For correspondence: johnsonp@pediatrics.ohio-state.edu
Bruce C. Schnepp
1Center for Gene Therapy, Columbus Children's Research Institute, Columbus Children's Hospital, and Department of Pediatrics, College of Medicine and Public Health, Ohio State University, Columbus, Ohio
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Mary J. Connell
1Center for Gene Therapy, Columbus Children's Research Institute, Columbus Children's Hospital, and Department of Pediatrics, College of Medicine and Public Health, Ohio State University, Columbus, Ohio
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Daniela Rohne
2Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
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Suzanne Robinson
2Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
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Georgia R. Krivulka
2Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
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Carol I. Lord
2Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
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Rebekah Zinn
3Department of Surgery, Duke University Medical Center, Durham, North Carolina
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David C. Montefiori
3Department of Surgery, Duke University Medical Center, Durham, North Carolina
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Norman L. Letvin
2Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
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K. Reed Clark
1Center for Gene Therapy, Columbus Children's Research Institute, Columbus Children's Hospital, and Department of Pediatrics, College of Medicine and Public Health, Ohio State University, Columbus, Ohio
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DOI: 10.1128/JVI.79.2.955-965.2005
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ABSTRACT

Gene transfer vectors based on recombinant adeno-associated virus (rAAV) are simple, versatile, and safe. While the conventional applications for rAAV vectors have focused on delivery of therapeutic genes, we have developed the system for delivery of vaccine antigens. In particular, we are interested in generating rAAV vectors for use as a prophylactic human immunodeficiency virus type 1 (HIV-1) vaccine. To that end, we constructed vaccine vectors that expressed genes from the simian immunodeficiency virus (SIV) for evaluation in the monkey SIV model. After a single intramuscular dose, rAAV/SIV vaccines elicited SIV-specific T cells and antibodies in macaques. Furthermore, immunized animals were able to significantly restrict replication of a live, virulent SIV challenge. These data suggest that rAAV vaccine vectors induced biologically relevant immune responses, and thus, warrant continued development as a viable HIV-1 vaccine candidate.

  • Copyright © 2005 American Society for Microbiology
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Novel Adeno-Associated Virus Vector Vaccine Restricts Replication of Simian Immunodeficiency Virus in Macaques
Philip R. Johnson, Bruce C. Schnepp, Mary J. Connell, Daniela Rohne, Suzanne Robinson, Georgia R. Krivulka, Carol I. Lord, Rebekah Zinn, David C. Montefiori, Norman L. Letvin, K. Reed Clark
Journal of Virology Dec 2004, 79 (2) 955-965; DOI: 10.1128/JVI.79.2.955-965.2005

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Novel Adeno-Associated Virus Vector Vaccine Restricts Replication of Simian Immunodeficiency Virus in Macaques
Philip R. Johnson, Bruce C. Schnepp, Mary J. Connell, Daniela Rohne, Suzanne Robinson, Georgia R. Krivulka, Carol I. Lord, Rebekah Zinn, David C. Montefiori, Norman L. Letvin, K. Reed Clark
Journal of Virology Dec 2004, 79 (2) 955-965; DOI: 10.1128/JVI.79.2.955-965.2005
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KEYWORDS

Dependovirus
SAIDS Vaccines
simian immunodeficiency virus
Vaccines, Synthetic
virus replication

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