Vaccines and Antiviral Agents
Immunization with Modified Vaccinia Virus Ankara-Based Recombinant Vaccine against Severe Acute Respiratory Syndrome Is Associated with Enhanced Hepatitis in Ferrets
Hana Weingartl, Markus Czub, Stefanie Czub, James Neufeld, Peter Marszal, Jason Gren, Greg Smith, Shane Jones, Roxanne Proulx, Yvonne Deschambault, Elsie Grudeski, Anton Andonov, Runtao He, Yan Li, John Copps, Allen Grolla, Daryl Dick, Jody Berry, Shelley Ganske, Lisa Manning, Jingxin Cao
Hana Weingartl
1National Centre for Foreign Animal Diseases
2Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
Markus Czub
2Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
Stefanie Czub
1National Centre for Foreign Animal Diseases
2Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
James Neufeld
1National Centre for Foreign Animal Diseases
Peter Marszal
1National Centre for Foreign Animal Diseases
Jason Gren
1National Centre for Foreign Animal Diseases
Greg Smith
1National Centre for Foreign Animal Diseases
Shane Jones
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
Roxanne Proulx
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
Yvonne Deschambault
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
Elsie Grudeski
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
Anton Andonov
2Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
Runtao He
2Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
Yan Li
2Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
John Copps
1National Centre for Foreign Animal Diseases
Allen Grolla
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
Daryl Dick
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
Jody Berry
1National Centre for Foreign Animal Diseases
2Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
Shelley Ganske
1National Centre for Foreign Animal Diseases
Lisa Manning
1National Centre for Foreign Animal Diseases
Jingxin Cao
2Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
DOI: 10.1128/JVI.78.22.12672-12676.2004

ABSTRACT
Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) is a serious emerging human infectious disease. In this report, we immunized ferrets (Mustela putorius furo) with recombinant modified vaccinia virus Ankara (rMVA) expressing the SARS-CoV spike (S) protein. Immunized ferrets developed a more rapid and vigorous neutralizing antibody response than control animals after challenge with SARS-CoV; however, they also exhibited strong inflammatory responses in liver tissue. Inflammation in control animals exposed to SARS-CoV was relatively mild. Thus, our data suggest that vaccination with rMVA expressing SARS-CoV S protein is associated with enhanced hepatitis.
- Copyright © 2004 American Society for Microbiology
Immunization with Modified Vaccinia Virus Ankara-Based Recombinant Vaccine against Severe Acute Respiratory Syndrome Is Associated with Enhanced Hepatitis in Ferrets
Hana Weingartl, Markus Czub, Stefanie Czub, James Neufeld, Peter Marszal, Jason Gren, Greg Smith, Shane Jones, Roxanne Proulx, Yvonne Deschambault, Elsie Grudeski, Anton Andonov, Runtao He, Yan Li, John Copps, Allen Grolla, Daryl Dick, Jody Berry, Shelley Ganske, Lisa Manning, Jingxin Cao
Journal of Virology Oct 2004, 78 (22) 12672-12676; DOI: 10.1128/JVI.78.22.12672-12676.2004
Immunization with Modified Vaccinia Virus Ankara-Based Recombinant Vaccine against Severe Acute Respiratory Syndrome Is Associated with Enhanced Hepatitis in Ferrets
Hana Weingartl, Markus Czub, Stefanie Czub, James Neufeld, Peter Marszal, Jason Gren, Greg Smith, Shane Jones, Roxanne Proulx, Yvonne Deschambault, Elsie Grudeski, Anton Andonov, Runtao He, Yan Li, John Copps, Allen Grolla, Daryl Dick, Jody Berry, Shelley Ganske, Lisa Manning, Jingxin Cao
Journal of Virology Oct 2004, 78 (22) 12672-12676; DOI: 10.1128/JVI.78.22.12672-12676.2004