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Vaccines and Antiviral Agents

Immunization with Modified Vaccinia Virus Ankara-Based Recombinant Vaccine against Severe Acute Respiratory Syndrome Is Associated with Enhanced Hepatitis in Ferrets

Hana Weingartl, Markus Czub, Stefanie Czub, James Neufeld, Peter Marszal, Jason Gren, Greg Smith, Shane Jones, Roxanne Proulx, Yvonne Deschambault, Elsie Grudeski, Anton Andonov, Runtao He, Yan Li, John Copps, Allen Grolla, Daryl Dick, Jody Berry, Shelley Ganske, Lisa Manning, Jingxin Cao
Hana Weingartl
1National Centre for Foreign Animal Diseases
2Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
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Markus Czub
2Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
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Stefanie Czub
1National Centre for Foreign Animal Diseases
2Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
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James Neufeld
1National Centre for Foreign Animal Diseases
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Peter Marszal
1National Centre for Foreign Animal Diseases
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Jason Gren
1National Centre for Foreign Animal Diseases
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Greg Smith
1National Centre for Foreign Animal Diseases
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Shane Jones
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
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Roxanne Proulx
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
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Yvonne Deschambault
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
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Elsie Grudeski
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
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Anton Andonov
2Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
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Runtao He
2Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
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Yan Li
2Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
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John Copps
1National Centre for Foreign Animal Diseases
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Allen Grolla
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
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Daryl Dick
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
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Jody Berry
1National Centre for Foreign Animal Diseases
2Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
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Shelley Ganske
1National Centre for Foreign Animal Diseases
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Lisa Manning
1National Centre for Foreign Animal Diseases
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Jingxin Cao
2Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
3National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada R3E 3R2
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  • For correspondence: jingxin_cao@hc-sc.gc.ca
DOI: 10.1128/JVI.78.22.12672-12676.2004
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ABSTRACT

Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) is a serious emerging human infectious disease. In this report, we immunized ferrets (Mustela putorius furo) with recombinant modified vaccinia virus Ankara (rMVA) expressing the SARS-CoV spike (S) protein. Immunized ferrets developed a more rapid and vigorous neutralizing antibody response than control animals after challenge with SARS-CoV; however, they also exhibited strong inflammatory responses in liver tissue. Inflammation in control animals exposed to SARS-CoV was relatively mild. Thus, our data suggest that vaccination with rMVA expressing SARS-CoV S protein is associated with enhanced hepatitis.

  • Copyright © 2004 American Society for Microbiology
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Immunization with Modified Vaccinia Virus Ankara-Based Recombinant Vaccine against Severe Acute Respiratory Syndrome Is Associated with Enhanced Hepatitis in Ferrets
Hana Weingartl, Markus Czub, Stefanie Czub, James Neufeld, Peter Marszal, Jason Gren, Greg Smith, Shane Jones, Roxanne Proulx, Yvonne Deschambault, Elsie Grudeski, Anton Andonov, Runtao He, Yan Li, John Copps, Allen Grolla, Daryl Dick, Jody Berry, Shelley Ganske, Lisa Manning, Jingxin Cao
Journal of Virology Oct 2004, 78 (22) 12672-12676; DOI: 10.1128/JVI.78.22.12672-12676.2004

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Immunization with Modified Vaccinia Virus Ankara-Based Recombinant Vaccine against Severe Acute Respiratory Syndrome Is Associated with Enhanced Hepatitis in Ferrets
Hana Weingartl, Markus Czub, Stefanie Czub, James Neufeld, Peter Marszal, Jason Gren, Greg Smith, Shane Jones, Roxanne Proulx, Yvonne Deschambault, Elsie Grudeski, Anton Andonov, Runtao He, Yan Li, John Copps, Allen Grolla, Daryl Dick, Jody Berry, Shelley Ganske, Lisa Manning, Jingxin Cao
Journal of Virology Oct 2004, 78 (22) 12672-12676; DOI: 10.1128/JVI.78.22.12672-12676.2004
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KEYWORDS

hepatitis
Membrane Glycoproteins
SARS Virus
Vaccines, Synthetic
vaccinia virus
Viral Envelope Proteins
Viral Vaccines

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