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RECOMBINATION AND EVOLUTION

Np9 Protein of Human Endogenous Retrovirus K Interacts with Ligand of Numb Protein X

Vivienne Armbruester, Marlies Sauter, Klaus Roemer, Barbara Best, Steffen Hahn, Achille Nty, Andreas Schmid, Stephan Philipp, Anja Mueller, Nikolaus Mueller-Lantzsch
Vivienne Armbruester
1Department of Virology
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Marlies Sauter
1Department of Virology
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Klaus Roemer
1Department of Virology
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Barbara Best
1Department of Virology
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Steffen Hahn
1Department of Virology
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Achille Nty
1Department of Virology
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Andreas Schmid
2Institute for Physiology
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Stephan Philipp
3Institute for Pharmacology and Toxicology, University of the Saarland Medical School, Homburg/Saar, Germany
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Anja Mueller
4Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom
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Nikolaus Mueller-Lantzsch
1Department of Virology
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  • For correspondence: vinmue@med-rz.uni-sb.de
DOI: 10.1128/JVI.78.19.10310-10319.2004
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ABSTRACT

We have recently identified Np9 as a novel nuclear protein produced by the human endogenous retrovirus K and were able to document the exclusive presence of np9 transcript in tumors and transformed cells. With the aim of studying whether Np9 has a role in tumorigenesis, a systematic search for interacting proteins was performed. Here, we identify the RING-type E3 ubiquitin ligase LNX (ligand of Numb protein X) as an Np9-interacting partner. We furthermore show that the interaction involves N- and C-terminal domains of both proteins and can affect the subcellular localization of LNX. LNX has been reported to target the cell fate determinant and Notch antagonist Numb for proteasome-dependent degradation, thereby causing an increase in transactivational activity of Notch. We document that LNX-interacting Np9, like Numb, is unstable and degraded via the proteasome pathway and that ectopic Numb can stabilize recombinant Np9. Combined, these findings point to the possibility that Np9 affects tumorigenesis through the LNX/Numb/Notch pathway.

  • Copyright © 2004 American Society for Microbiology
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Np9 Protein of Human Endogenous Retrovirus K Interacts with Ligand of Numb Protein X
Vivienne Armbruester, Marlies Sauter, Klaus Roemer, Barbara Best, Steffen Hahn, Achille Nty, Andreas Schmid, Stephan Philipp, Anja Mueller, Nikolaus Mueller-Lantzsch
Journal of Virology Sep 2004, 78 (19) 10310-10319; DOI: 10.1128/JVI.78.19.10310-10319.2004

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Np9 Protein of Human Endogenous Retrovirus K Interacts with Ligand of Numb Protein X
Vivienne Armbruester, Marlies Sauter, Klaus Roemer, Barbara Best, Steffen Hahn, Achille Nty, Andreas Schmid, Stephan Philipp, Anja Mueller, Nikolaus Mueller-Lantzsch
Journal of Virology Sep 2004, 78 (19) 10310-10319; DOI: 10.1128/JVI.78.19.10310-10319.2004
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KEYWORDS

Carrier Proteins
Gene Products, env

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