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REPLICATION

Human Immunodeficiency Virus Type 1 Envelope Glycoproteins That Lack Cytoplasmic Domain Cysteines: Impact on Association with Membrane Lipid Rafts and Incorporation onto Budding Virus Particles

Jayanta Bhattacharya, Paul J. Peters, Paul R. Clapham
Jayanta Bhattacharya
Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605
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Paul J. Peters
Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605
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Paul R. Clapham
Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605
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  • For correspondence: paul.clapham@umassmed.edu
DOI: 10.1128/JVI.78.10.5500-5506.2004
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Article Information

DOI 
https://doi.org/10.1128/JVI.78.10.5500-5506.2004
PubMed 
15113929

Published By 
American Society for Microbiology Journals
History 
  • Received September 10, 2003
  • Accepted January 24, 2004
  • Published online April 27, 2004.

Copyright & Usage 
Copyright © 2004 American Society for Microbiology

Author Information

  1. Jayanta Bhattacharya,
  2. Paul J. Peters and
  3. Paul R. Clapham*
  1. Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605
  • ↵* Corresponding author. Mailing address: Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, 373 Plantation St., Suite 315, Biotech 2, University of Massachusetts Medical School, Worcester, MA 01605. Phone: (508) 856-6281. Fax: (508) 856-4283. E-mail: paul.clapham{at}umassmed.edu .

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Human Immunodeficiency Virus Type 1 Envelope Glycoproteins That Lack Cytoplasmic Domain Cysteines: Impact on Association with Membrane Lipid Rafts and Incorporation onto Budding Virus Particles
Jayanta Bhattacharya, Paul J. Peters, Paul R. Clapham
Journal of Virology Apr 2004, 78 (10) 5500-5506; DOI: 10.1128/JVI.78.10.5500-5506.2004

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Human Immunodeficiency Virus Type 1 Envelope Glycoproteins That Lack Cytoplasmic Domain Cysteines: Impact on Association with Membrane Lipid Rafts and Incorporation onto Budding Virus Particles
Jayanta Bhattacharya, Paul J. Peters, Paul R. Clapham
Journal of Virology Apr 2004, 78 (10) 5500-5506; DOI: 10.1128/JVI.78.10.5500-5506.2004
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  • Top
  • Article
    • ABSTRACT
    • Construction of NL43 gp41 mutants.
    • Mutant NL43 envelopes lacking cytoplasmic cysteines are expressed and functional.
    • Effect of gp41 mutations on infectivity.
    • Effect of gp41 mutations on envelope incorporation onto virions.
    • Association of envelope mutants with lipid rafts.
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

HIV Envelope Protein gp41
HIV-1
Membrane Microdomains
virion

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