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Vaccines and Antiviral Agents

High-Frequency Phenotypic Reversion and Pathogenicity of an Acyclovir-Resistant Herpes Simplex Virus Mutant

Anthony Griffiths, Donald M. Coen
Anthony Griffiths
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
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Donald M. Coen
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
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  • For correspondence: Don_Coen@hms.harvard.edu
DOI: 10.1128/JVI.77.3.2282-2286.2003
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Article Information

DOI 
https://doi.org/10.1128/JVI.77.3.2282-2286.2003
PubMed 
12525666

Published By 
American Society for Microbiology Journals
History 
  • Received July 24, 2002
  • Accepted October 24, 2002
  • Published online February 1, 2003.

Copyright & Usage 
Copyright © 2003 American Society for Microbiology

Author Information

  1. Anthony Griffiths and
  2. Donald M. Coen*
  1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
  • ↵* Corresponding author. Mailing address: Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Ave., Boston, MA 02115. Phone: (617) 432-1691. Fax: (617) 432-3833. E-mail: Don_Coen{at}hms.harvard.edu .
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High-Frequency Phenotypic Reversion and Pathogenicity of an Acyclovir-Resistant Herpes Simplex Virus Mutant
Anthony Griffiths, Donald M. Coen
Journal of Virology Feb 2003, 77 (3) 2282-2286; DOI: 10.1128/JVI.77.3.2282-2286.2003

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High-Frequency Phenotypic Reversion and Pathogenicity of an Acyclovir-Resistant Herpes Simplex Virus Mutant
Anthony Griffiths, Donald M. Coen
Journal of Virology Feb 2003, 77 (3) 2282-2286; DOI: 10.1128/JVI.77.3.2282-2286.2003
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  • Top
  • Article
    • ABSTRACT
    • Construction of recombinant virus TKG7+2G.
    • Heterogeneity of TK activity of virus carrying a double-G insertion.
    • Enrichment of virus with high levels of TK activity during acute replication in the mouse.
    • Reactivation from latency.
    • What accounts for the low level of TK activity of most TKG7+2G plaques?
    • What causes the high frequency of phenotypic reversion?
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

Acyclovir
antiviral agents
Simplexvirus
thymidine kinase

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