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Pathogenesis and Immunity

An Attenuating Mutation in nsP1 of the Sindbis-Group Virus S.A.AR86 Accelerates Nonstructural Protein Processing and Up-Regulates Viral 26S RNA Synthesis

Mark T. Heise, Laura J. White, Dennis A. Simpson, Christopher Leonard, Kristen A. Bernard, Rick B. Meeker, Robert E. Johnston
Mark T. Heise
1Department of Microbiology and Immunology
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  • For correspondence: heisem@med.unc.edu
Laura J. White
1Department of Microbiology and Immunology
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Dennis A. Simpson
1Department of Microbiology and Immunology
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Christopher Leonard
1Department of Microbiology and Immunology
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Kristen A. Bernard
1Department of Microbiology and Immunology
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Rick B. Meeker
2Department of Neurology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
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Robert E. Johnston
1Department of Microbiology and Immunology
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DOI: 10.1128/JVI.77.2.1149-1156.2003
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Article Information

DOI 
https://doi.org/10.1128/JVI.77.2.1149-1156.2003
PubMed 
12502831

Published By 
American Society for Microbiology Journals
History 
  • Received May 28, 2002
  • Accepted October 8, 2002
  • Published online January 15, 2003.

Copyright & Usage 
Copyright © 2003 American Society for Microbiology

Author Information

  1. Mark T. Heise1*,
  2. Laura J. White1,
  3. Dennis A. Simpson1†,
  4. Christopher Leonard1,
  5. Kristen A. Bernard1‡,
  6. Rick B. Meeker2 and
  7. Robert E. Johnston1
  1. 1Department of Microbiology and Immunology
  2. 2Department of Neurology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
  • ↵* Corresponding author. Mailing address: Department of Microbiology and Immunology, Campus Box 7290, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599. Phone: (919) 966-4026. Fax: (919) 962-8103. E-mail: heisem{at}med.unc.edu .
  • ↵† Present address: Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; ‡ Present address: Arbovirus Laboratories, The Wadsworth Center, The New York State Department of Health, Slingerlands, NY 12159.

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An Attenuating Mutation in nsP1 of the Sindbis-Group Virus S.A.AR86 Accelerates Nonstructural Protein Processing and Up-Regulates Viral 26S RNA Synthesis
Mark T. Heise, Laura J. White, Dennis A. Simpson, Christopher Leonard, Kristen A. Bernard, Rick B. Meeker, Robert E. Johnston
Journal of Virology Jan 2003, 77 (2) 1149-1156; DOI: 10.1128/JVI.77.2.1149-1156.2003

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An Attenuating Mutation in nsP1 of the Sindbis-Group Virus S.A.AR86 Accelerates Nonstructural Protein Processing and Up-Regulates Viral 26S RNA Synthesis
Mark T. Heise, Laura J. White, Dennis A. Simpson, Christopher Leonard, Kristen A. Bernard, Rick B. Meeker, Robert E. Johnston
Journal of Virology Jan 2003, 77 (2) 1149-1156; DOI: 10.1128/JVI.77.2.1149-1156.2003
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KEYWORDS

mutation
Protein Processing, Post-Translational
RNA, Viral
Sindbis virus
Up-Regulation
viral nonstructural proteins

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