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Vaccines and Antiviral Agents

Dynamics of Subgenomic Hepatitis C Virus Replicon RNA Levels in Huh-7 Cells after Exposure to Nucleoside Antimetabolites

Lieven J. Stuyver, Tamara R. McBrayer, Phillip M. Tharnish, Abdalla E. A. Hassan, Chung K. Chu, Krzysztof W. Pankiewicz, Kyochi A. Watanabe, Raymond F. Schinazi, Michael J. Otto
Lieven J. Stuyver
1Pharmasset, Inc., Tucker, Georgia 30084
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  • For correspondence: lstuyver@pharmasset.com
Tamara R. McBrayer
1Pharmasset, Inc., Tucker, Georgia 30084
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Phillip M. Tharnish
1Pharmasset, Inc., Tucker, Georgia 30084
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Abdalla E. A. Hassan
1Pharmasset, Inc., Tucker, Georgia 30084
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Chung K. Chu
2College of Pharmacy, University of Georgia, Athens, Georgia 30602
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Krzysztof W. Pankiewicz
1Pharmasset, Inc., Tucker, Georgia 30084
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Kyochi A. Watanabe
1Pharmasset, Inc., Tucker, Georgia 30084
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Raymond F. Schinazi
3Veterans Affairs Medical Center and Department of Pediatrics, Emory University School of Medicine, Decatur, Georgia 30033
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Michael J. Otto
1Pharmasset, Inc., Tucker, Georgia 30084
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DOI: 10.1128/JVI.77.19.10689-10694.2003
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Article Information

DOI 
https://doi.org/10.1128/JVI.77.19.10689-10694.2003
PubMed 
12970456

Published By 
American Society for Microbiology Journals
History 
  • Received May 15, 2003
  • Accepted July 10, 2003
  • Published online September 11, 2003.

Copyright & Usage 
Copyright © 2003 American Society for Microbiology

Author Information

  1. Lieven J. Stuyver1*,
  2. Tamara R. McBrayer1,
  3. Phillip M. Tharnish1,
  4. Abdalla E. A. Hassan1,
  5. Chung K. Chu2,
  6. Krzysztof W. Pankiewicz1,
  7. Kyochi A. Watanabe1,
  8. Raymond F. Schinazi3 and
  9. Michael J. Otto1
  1. 1Pharmasset, Inc., Tucker, Georgia 30084
  2. 2College of Pharmacy, University of Georgia, Athens, Georgia 30602
  3. 3Veterans Affairs Medical Center and Department of Pediatrics, Emory University School of Medicine, Decatur, Georgia 30033
  • ↵* Corresponding author. Mailing address: Pharmasset, Inc., 1860 Montreal Rd., Tucker, GA 30084. Phone: (678) 395-0050. Fax: (678) 395-0030. E-mail: lstuyver{at}pharmasset.com .
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Dynamics of Subgenomic Hepatitis C Virus Replicon RNA Levels in Huh-7 Cells after Exposure to Nucleoside Antimetabolites
Lieven J. Stuyver, Tamara R. McBrayer, Phillip M. Tharnish, Abdalla E. A. Hassan, Chung K. Chu, Krzysztof W. Pankiewicz, Kyochi A. Watanabe, Raymond F. Schinazi, Michael J. Otto
Journal of Virology Sep 2003, 77 (19) 10689-10694; DOI: 10.1128/JVI.77.19.10689-10694.2003

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Dynamics of Subgenomic Hepatitis C Virus Replicon RNA Levels in Huh-7 Cells after Exposure to Nucleoside Antimetabolites
Lieven J. Stuyver, Tamara R. McBrayer, Phillip M. Tharnish, Abdalla E. A. Hassan, Chung K. Chu, Krzysztof W. Pankiewicz, Kyochi A. Watanabe, Raymond F. Schinazi, Michael J. Otto
Journal of Virology Sep 2003, 77 (19) 10689-10694; DOI: 10.1128/JVI.77.19.10689-10694.2003
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  • Top
  • Article
    • ABSTRACT
    • Specificity of the antiviral effect in the HCV replicon system.
    • Antiviral effect of antimetabolites.
    • Dynamics of the antiviral effect of inhibitors of the de novo synthesis of ribopyrimidines.
    • Reduction of replicon RNA copy number per cell.
    • Prevention studies.
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

Antimetabolites
antiviral agents
hepacivirus
Nucleosides
RNA, Viral
replicon

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