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GENE THERAPY

Extensive Cross-Reactivity of CD4+ Adenovirus-Specific T Cells: Implications for Immunotherapy and Gene Therapy

Bianca Heemskerk, Louise A. Veltrop-Duits, Tamara van Vreeswijk, Monique M. ten Dam, Sebastiaan Heidt, Rene E. M. Toes, Maarten J. D. van Tol, Marco W. Schilham
Bianca Heemskerk
1Department of Pediatrics
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  • For correspondence: B.Heemskerk@lumc.nl
Louise A. Veltrop-Duits
1Department of Pediatrics
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Tamara van Vreeswijk
1Department of Pediatrics
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Monique M. ten Dam
1Department of Pediatrics
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Sebastiaan Heidt
1Department of Pediatrics
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Rene E. M. Toes
2Department of Rheumatology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
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Maarten J. D. van Tol
1Department of Pediatrics
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Marco W. Schilham
1Department of Pediatrics
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DOI: 10.1128/JVI.77.11.6562-6566.2003
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Article Information

DOI 
https://doi.org/10.1128/JVI.77.11.6562-6566.2003
PubMed 
12743315

Published By 
American Society for Microbiology Journals
History 
  • Received December 6, 2002
  • Accepted March 4, 2003
  • Published online June 1, 2003.

Copyright & Usage 
Copyright © 2003 American Society for Microbiology

Author Information

  1. Bianca Heemskerk1*,
  2. Louise A. Veltrop-Duits1,
  3. Tamara van Vreeswijk1,
  4. Monique M. ten Dam1,
  5. Sebastiaan Heidt1,
  6. Rene E. M. Toes2,
  7. Maarten J. D. van Tol1 and
  8. Marco W. Schilham1
  1. 1Department of Pediatrics
  2. 2Department of Rheumatology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
  • ↵* Corresponding author. Mailing address: Department of Pediatrics, P3-P, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands. Phone: 31-71-5263626. Fax: 31-71-5266876. E-mail: B.Heemskerk{at}lumc.nl .
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Extensive Cross-Reactivity of CD4+ Adenovirus-Specific T Cells: Implications for Immunotherapy and Gene Therapy
Bianca Heemskerk, Louise A. Veltrop-Duits, Tamara van Vreeswijk, Monique M. ten Dam, Sebastiaan Heidt, Rene E. M. Toes, Maarten J. D. van Tol, Marco W. Schilham
Journal of Virology Jun 2003, 77 (11) 6562-6566; DOI: 10.1128/JVI.77.11.6562-6566.2003

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Extensive Cross-Reactivity of CD4+ Adenovirus-Specific T Cells: Implications for Immunotherapy and Gene Therapy
Bianca Heemskerk, Louise A. Veltrop-Duits, Tamara van Vreeswijk, Monique M. ten Dam, Sebastiaan Heidt, Rene E. M. Toes, Maarten J. D. van Tol, Marco W. Schilham
Journal of Virology Jun 2003, 77 (11) 6562-6566; DOI: 10.1128/JVI.77.11.6562-6566.2003
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  • Top
  • Article
    • ABSTRACT
    • Inactivation of Ad.
    • Frequency of T-cell responses to MB-inactivated Ad5.
    • Increased Ad-specific IFN-γ production and reduced alloreactivity after restimulation.
    • Cross-reactivity of Ad5-specific bulk cultures and T-cell clones.
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

Adenoviruses, Human
CD4-Positive T-Lymphocytes
Genetic Therapy
Immunotherapy, Adoptive

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