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Pathogenesis and Immunity

Involvement of Apolipoprotein E in the Hematogenous Route of Herpes Simplex Virus Type 1 to the Central Nervous System

Javier S. Burgos, Carlos Ramirez, Isabel Sastre, María J. Bullido, Fernando Valdivieso
Javier S. Burgos
Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
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Carlos Ramirez
Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
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Isabel Sastre
Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
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María J. Bullido
Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
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Fernando Valdivieso
Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
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  • For correspondence: fvaldivieso@cbm.uam.es
DOI: 10.1128/JVI.76.23.12394-12398.2002
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    FIG. 1.

    Time courses of HSV-1 infection in the several analyzed organs. Solid lines represent the wild-type mouse group; dotted lines represent the apoE knockout mouse group. Values are expressed as means ± standard errors of the mean (∗, P < 0.01; ∗∗, P < 0.001 [Fischer's exact test]).

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    FIG. 2.

    Quantification of the viral load in relation to ApoE dosage on day 5.7. The inset presents the results for the four dissected areas of the brain analyzed in this study. Values are expressed as means ± standard errors of the mean (∗∗, P < 0.001 [Fischer's exact test]).

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Involvement of Apolipoprotein E in the Hematogenous Route of Herpes Simplex Virus Type 1 to the Central Nervous System
Javier S. Burgos, Carlos Ramirez, Isabel Sastre, María J. Bullido, Fernando Valdivieso
Journal of Virology Dec 2002, 76 (23) 12394-12398; DOI: 10.1128/JVI.76.23.12394-12398.2002

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Involvement of Apolipoprotein E in the Hematogenous Route of Herpes Simplex Virus Type 1 to the Central Nervous System
Javier S. Burgos, Carlos Ramirez, Isabel Sastre, María J. Bullido, Fernando Valdivieso
Journal of Virology Dec 2002, 76 (23) 12394-12398; DOI: 10.1128/JVI.76.23.12394-12398.2002
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KEYWORDS

Apolipoproteins E
central nervous system infections
herpes simplex
Herpesvirus 1, Human

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