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Pathogenesis and Immunity

Compromised Influenza Virus-Specific CD8+-T-Cell Memory in CD4+-T-Cell-Deficient Mice

Gabrielle T. Belz, Dominik Wodarz, Gabriela Diaz, Martin A. Nowak, Peter C. Doherty
Gabrielle T. Belz
1Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105
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Dominik Wodarz
2Program in Theoretical Biology, Institute for Advanced Study, Princeton, New Jersey 08540
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Gabriela Diaz
1Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105
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Martin A. Nowak
2Program in Theoretical Biology, Institute for Advanced Study, Princeton, New Jersey 08540
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Peter C. Doherty
1Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105
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  • For correspondence: peter.doherty@stjude.org
DOI: 10.1128/JVI.76.23.12388-12393.2002
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Article Information

DOI 
https://doi.org/10.1128/JVI.76.23.12388-12393.2002
PubMed 
12414983

Published By 
American Society for Microbiology Journals
History 
  • Received May 13, 2002
  • Accepted August 28, 2002
  • Published online December 1, 2002.

Copyright & Usage 
Copyright © 2002 American Society for Microbiology

Author Information

  1. Gabrielle T. Belz1†,
  2. Dominik Wodarz2‡,
  3. Gabriela Diaz1,
  4. Martin A. Nowak2 and
  5. Peter C. Doherty1*
  1. 1Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105
  2. 2Program in Theoretical Biology, Institute for Advanced Study, Princeton, New Jersey 08540
  • ↵* Corresponding author. Mailing address: Department of Immunology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105. Phone: (901) 495-3470. Fax: (901) 495-3107. E-mail: peter.doherty{at}stjude.org .
  • ↵† Present address: Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia.; ‡ Present address: : Fred Hutchinson Cancer Research Center, Seattle, WA 98109.

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Compromised Influenza Virus-Specific CD8+-T-Cell Memory in CD4+-T-Cell-Deficient Mice
Gabrielle T. Belz, Dominik Wodarz, Gabriela Diaz, Martin A. Nowak, Peter C. Doherty
Journal of Virology Dec 2002, 76 (23) 12388-12393; DOI: 10.1128/JVI.76.23.12388-12393.2002

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Compromised Influenza Virus-Specific CD8+-T-Cell Memory in CD4+-T-Cell-Deficient Mice
Gabrielle T. Belz, Dominik Wodarz, Gabriela Diaz, Martin A. Nowak, Peter C. Doherty
Journal of Virology Dec 2002, 76 (23) 12388-12393; DOI: 10.1128/JVI.76.23.12388-12393.2002
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  • Top
  • Article
    • ABSTRACT
    • Experimental procedures.
    • Mathematical modeling.
    • Virus clearance and CTL effector function.
    • Quantitation of the CD8+-T-cell response.
    • CD4+-T-cell help for B cells and CD8+ T cells.
    • Application of the mathematical model.
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
influenza A virus

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