Inhibitory Mechanism of the CXCR4 Antagonist T22 against Human Immunodeficiency Virus Type 1 Infection

Department of Microbiology and Molecular Virology, Faculty of Medicine, Tokyo Medical and Dental University,Bunkyo-ku, Tokyo 113-8519, University of the Ryukyus, Okinawa 903-0215, Institute for Virus Research,Kyoto University, Kyoto 606-01, Graduate School of Pharmaceutical Sciences, Kyoto University,Kyoto 606-8501, Seikagaku Corporation, Tokyo 103, and Department of Medical Chemistry,Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan; University of Louisville,Louisville, Kentucky 40202; Genentech, South San Francisco, California 94080; andUniversity of Pennsylvania, Philadelphia, Pennsylvania 19104

Department of Microbiology and Molecular Virology, Faculty of Medicine, Tokyo Medical and Dental University,Bunkyo-ku, Tokyo 113-8519, University of the Ryukyus, Okinawa 903-0215, Institute for Virus Research,Kyoto University, Kyoto 606-01, Graduate School of Pharmaceutical Sciences, Kyoto University,Kyoto 606-8501, Seikagaku Corporation, Tokyo 103, and Department of Medical Chemistry,Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan; University of Louisville,Louisville, Kentucky 40202; Genentech, South San Francisco, California 94080; andUniversity of Pennsylvania, Philadelphia, Pennsylvania 19104

Department of Microbiology and Molecular Virology, Faculty of Medicine, Tokyo Medical and Dental University,Bunkyo-ku, Tokyo 113-8519, University of the Ryukyus, Okinawa 903-0215, Institute for Virus Research,Kyoto University, Kyoto 606-01, Graduate School of Pharmaceutical Sciences, Kyoto University,Kyoto 606-8501, Seikagaku Corporation, Tokyo 103, and Department of Medical Chemistry,Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan; University of Louisville,Louisville, Kentucky 40202; Genentech, South San Francisco, California 94080; andUniversity of Pennsylvania, Philadelphia, Pennsylvania 19104

Department of Microbiology and Molecular Virology, Faculty of Medicine, Tokyo Medical and Dental University,Bunkyo-ku, Tokyo 113-8519, University of the Ryukyus, Okinawa 903-0215, Institute for Virus Research,Kyoto University, Kyoto 606-01, Graduate School of Pharmaceutical Sciences, Kyoto University,Kyoto 606-8501, Seikagaku Corporation, Tokyo 103, and Department of Medical Chemistry,Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan; University of Louisville,Louisville, Kentucky 40202; Genentech, South San Francisco, California 94080; andUniversity of Pennsylvania, Philadelphia, Pennsylvania 19104

Department of Microbiology and Molecular Virology, Faculty of Medicine, Tokyo Medical and Dental University,Bunkyo-ku, Tokyo 113-8519, University of the Ryukyus, Okinawa 903-0215, Institute for Virus Research,Kyoto University, Kyoto 606-01, Graduate School of Pharmaceutical Sciences, Kyoto University,Kyoto 606-8501, Seikagaku Corporation, Tokyo 103, and Department of Medical Chemistry,Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan; University of Louisville,Louisville, Kentucky 40202; Genentech, South San Francisco, California 94080; andUniversity of Pennsylvania, Philadelphia, Pennsylvania 19104

Department of Microbiology and Molecular Virology, Faculty of Medicine, Tokyo Medical and Dental University,Bunkyo-ku, Tokyo 113-8519, University of the Ryukyus, Okinawa 903-0215, Institute for Virus Research,Kyoto University, Kyoto 606-01, Graduate School of Pharmaceutical Sciences, Kyoto University,Kyoto 606-8501, Seikagaku Corporation, Tokyo 103, and Department of Medical Chemistry,Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan; University of Louisville,Louisville, Kentucky 40202; Genentech, South San Francisco, California 94080; andUniversity of Pennsylvania, Philadelphia, Pennsylvania 19104

Department of Microbiology and Molecular Virology, Faculty of Medicine, Tokyo Medical and Dental University,Bunkyo-ku, Tokyo 113-8519, University of the Ryukyus, Okinawa 903-0215, Institute for Virus Research,Kyoto University, Kyoto 606-01, Graduate School of Pharmaceutical Sciences, Kyoto University,Kyoto 606-8501, Seikagaku Corporation, Tokyo 103, and Department of Medical Chemistry,Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan; University of Louisville,Louisville, Kentucky 40202; Genentech, South San Francisco, California 94080; andUniversity of Pennsylvania, Philadelphia, Pennsylvania 19104

Department of Microbiology and Molecular Virology, Faculty of Medicine, Tokyo Medical and Dental University,Bunkyo-ku, Tokyo 113-8519, University of the Ryukyus, Okinawa 903-0215, Institute for Virus Research,Kyoto University, Kyoto 606-01, Graduate School of Pharmaceutical Sciences, Kyoto University,Kyoto 606-8501, Seikagaku Corporation, Tokyo 103, and Department of Medical Chemistry,Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan; University of Louisville,Louisville, Kentucky 40202; Genentech, South San Francisco, California 94080; andUniversity of Pennsylvania, Philadelphia, Pennsylvania 19104

Department of Microbiology and Molecular Virology, Faculty of Medicine, Tokyo Medical and Dental University,Bunkyo-ku, Tokyo 113-8519, University of the Ryukyus, Okinawa 903-0215, Institute for Virus Research,Kyoto University, Kyoto 606-01, Graduate School of Pharmaceutical Sciences, Kyoto University,Kyoto 606-8501, Seikagaku Corporation, Tokyo 103, and Department of Medical Chemistry,Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan; University of Louisville,Louisville, Kentucky 40202; Genentech, South San Francisco, California 94080; andUniversity of Pennsylvania, Philadelphia, Pennsylvania 19104

Department of Microbiology and Molecular Virology, Faculty of Medicine, Tokyo Medical and Dental University,Bunkyo-ku, Tokyo 113-8519, University of the Ryukyus, Okinawa 903-0215, Institute for Virus Research,Kyoto University, Kyoto 606-01, Graduate School of Pharmaceutical Sciences, Kyoto University,Kyoto 606-8501, Seikagaku Corporation, Tokyo 103, and Department of Medical Chemistry,Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan; University of Louisville,Louisville, Kentucky 40202; Genentech, South San Francisco, California 94080; andUniversity of Pennsylvania, Philadelphia, Pennsylvania 19104

Department of Microbiology and Molecular Virology, Faculty of Medicine, Tokyo Medical and Dental University,Bunkyo-ku, Tokyo 113-8519, University of the Ryukyus, Okinawa 903-0215, Institute for Virus Research,Kyoto University, Kyoto 606-01, Graduate School of Pharmaceutical Sciences, Kyoto University,Kyoto 606-8501, Seikagaku Corporation, Tokyo 103, and Department of Medical Chemistry,Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan; University of Louisville,Louisville, Kentucky 40202; Genentech, South San Francisco, California 94080; andUniversity of Pennsylvania, Philadelphia, Pennsylvania 19104

Department of Microbiology and Molecular Virology, Faculty of Medicine, Tokyo Medical and Dental University,Bunkyo-ku, Tokyo 113-8519, University of the Ryukyus, Okinawa 903-0215, Institute for Virus Research,Kyoto University, Kyoto 606-01, Graduate School of Pharmaceutical Sciences, Kyoto University,Kyoto 606-8501, Seikagaku Corporation, Tokyo 103, and Department of Medical Chemistry,Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan; University of Louisville,Louisville, Kentucky 40202; Genentech, South San Francisco, California 94080; andUniversity of Pennsylvania, Philadelphia, Pennsylvania 19104

Department of Microbiology and Molecular Virology, Faculty of Medicine, Tokyo Medical and Dental University,Bunkyo-ku, Tokyo 113-8519, University of the Ryukyus, Okinawa 903-0215, Institute for Virus Research,Kyoto University, Kyoto 606-01, Graduate School of Pharmaceutical Sciences, Kyoto University,Kyoto 606-8501, Seikagaku Corporation, Tokyo 103, and Department of Medical Chemistry,Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan; University of Louisville,Louisville, Kentucky 40202; Genentech, South San Francisco, California 94080; andUniversity of Pennsylvania, Philadelphia, Pennsylvania 19104

Department of Microbiology and Molecular Virology, Faculty of Medicine, Tokyo Medical and Dental University,Bunkyo-ku, Tokyo 113-8519, University of the Ryukyus, Okinawa 903-0215, Institute for Virus Research,Kyoto University, Kyoto 606-01, Graduate School of Pharmaceutical Sciences, Kyoto University,Kyoto 606-8501, Seikagaku Corporation, Tokyo 103, and Department of Medical Chemistry,Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan; University of Louisville,Louisville, Kentucky 40202; Genentech, South San Francisco, California 94080; andUniversity of Pennsylvania, Philadelphia, Pennsylvania 19104

Department of Microbiology and Molecular Virology, Faculty of Medicine, Tokyo Medical and Dental University,Bunkyo-ku, Tokyo 113-8519, University of the Ryukyus, Okinawa 903-0215, Institute for Virus Research,Kyoto University, Kyoto 606-01, Graduate School of Pharmaceutical Sciences, Kyoto University,Kyoto 606-8501, Seikagaku Corporation, Tokyo 103, and Department of Medical Chemistry,Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan; University of Louisville,Louisville, Kentucky 40202; Genentech, South San Francisco, California 94080; andUniversity of Pennsylvania, Philadelphia, Pennsylvania 19104