Cross-Packaging of a Single Adeno-Associated Virus (AAV) Type 2 Vector Genome into Multiple AAV Serotypes Enables Transduction with Broad Specificity

Joseph E. Rabinowitz; Fabienne Rolling; Chengwen Li; Hervè Conrath; Weidong Xiao; Xiao Xiao; R. Jude Samulski

doi:10.1128/JVI.76.2.791-801.2002

DOI: 10.1128/JVI.76.2.791-801.2002

Article Information

DOI

https://doi.org/10.1128/JVI.76.2.791-801.2002

PubMed

11752169

Published By

American Society for Microbiology Journals

History

Received August 7, 2001
Accepted October 9, 2001
Published online January 15, 2002.

Author Information

Joseph E. Rabinowitz¹,
Fabienne Rolling²,
Chengwen Li¹,
Hervè Conrath²,
Weidong Xiao³,
Xiao Xiao⁴ and
R. Jude Samulski¹,⁵ *

¹Gene Therapy Center
²Laboratoire de Thérapie Génique, CHU Hotel-DIEU, 44035 Nantes Cedex 01, France
³Division of Hematology, Department of Pediatrics, University of Pennsylvania School of Medicine and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
⁴Department of Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania
⁵Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina

↵* Corresponding author. Mailing address: Gene Therapy Center, The University of North Carolina at Chapel Hill, 7119 Thurston/Bowles CB7352, Chapel Hill, NC 27599-7352. Phone: (919) 966-0191. Fax: (919) 966-0907. E-mail: rjs{at}med.unc.edu.

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