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GENE THERAPY

Cross-Packaging of a Single Adeno-Associated Virus (AAV) Type 2 Vector Genome into Multiple AAV Serotypes Enables Transduction with Broad Specificity

Joseph E. Rabinowitz, Fabienne Rolling, Chengwen Li, Hervè Conrath, Weidong Xiao, Xiao Xiao, R. Jude Samulski
Joseph E. Rabinowitz
1Gene Therapy Center
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Fabienne Rolling
2Laboratoire de Thérapie Génique, CHU Hotel-DIEU, 44035 Nantes Cedex 01, France
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Chengwen Li
1Gene Therapy Center
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Hervè Conrath
2Laboratoire de Thérapie Génique, CHU Hotel-DIEU, 44035 Nantes Cedex 01, France
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Weidong Xiao
3Division of Hematology, Department of Pediatrics, University of Pennsylvania School of Medicine and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
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Xiao Xiao
4Department of Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania
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R. Jude Samulski
1Gene Therapy Center
5Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina
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  • For correspondence: rjs@med.unc.edu
DOI: 10.1128/JVI.76.2.791-801.2002
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Article Information

DOI 
https://doi.org/10.1128/JVI.76.2.791-801.2002
PubMed 
11752169

Published By 
American Society for Microbiology Journals
History 
  • Received August 7, 2001
  • Accepted October 9, 2001
  • Published online January 15, 2002.

Copyright & Usage 
Copyright © 2002 American Society for Microbiology

Author Information

  1. Joseph E. Rabinowitz1,
  2. Fabienne Rolling2,
  3. Chengwen Li1,
  4. Hervè Conrath2,
  5. Weidong Xiao3,
  6. Xiao Xiao4 and
  7. R. Jude Samulski1,5*
  1. 1Gene Therapy Center
  2. 2Laboratoire de Thérapie Génique, CHU Hotel-DIEU, 44035 Nantes Cedex 01, France
  3. 3Division of Hematology, Department of Pediatrics, University of Pennsylvania School of Medicine and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
  4. 4Department of Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania
  5. 5Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina
  • ↵* Corresponding author. Mailing address: Gene Therapy Center, The University of North Carolina at Chapel Hill, 7119 Thurston/Bowles CB7352, Chapel Hill, NC 27599-7352. Phone: (919) 966-0191. Fax: (919) 966-0907. E-mail: rjs{at}med.unc.edu.
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Cross-Packaging of a Single Adeno-Associated Virus (AAV) Type 2 Vector Genome into Multiple AAV Serotypes Enables Transduction with Broad Specificity
Joseph E. Rabinowitz, Fabienne Rolling, Chengwen Li, Hervè Conrath, Weidong Xiao, Xiao Xiao, R. Jude Samulski
Journal of Virology Jan 2002, 76 (2) 791-801; DOI: 10.1128/JVI.76.2.791-801.2002

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Cross-Packaging of a Single Adeno-Associated Virus (AAV) Type 2 Vector Genome into Multiple AAV Serotypes Enables Transduction with Broad Specificity
Joseph E. Rabinowitz, Fabienne Rolling, Chengwen Li, Hervè Conrath, Weidong Xiao, Xiao Xiao, R. Jude Samulski
Journal of Virology Jan 2002, 76 (2) 791-801; DOI: 10.1128/JVI.76.2.791-801.2002
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KEYWORDS

Dependovirus
Genetic Vectors
Genome, Viral
Transduction, Genetic
virus assembly

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