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Pathogenesis and Immunity

Growth of Rotaviruses in Primary Pancreatic Cells

Barbara S. Coulson, Paul D. Witterick, Yan Tan, Marilyn J. Hewish, Joanne N. Mountford, Leonard C. Harrison, Margo C. Honeyman
Barbara S. Coulson
1Department of Microbiology and Immunology, The University of Melbourne, Royal Parade, Victoria 3010
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  • For correspondence: barbarac@unimelb.edu.au
Paul D. Witterick
1Department of Microbiology and Immunology, The University of Melbourne, Royal Parade, Victoria 3010
2Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
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Yan Tan
1Department of Microbiology and Immunology, The University of Melbourne, Royal Parade, Victoria 3010
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Marilyn J. Hewish
1Department of Microbiology and Immunology, The University of Melbourne, Royal Parade, Victoria 3010
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Joanne N. Mountford
2Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
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Leonard C. Harrison
2Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
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Margo C. Honeyman
2Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
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DOI: 10.1128/JVI.76.18.9537-9544.2002
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ABSTRACT

Rotavirus infection in children at risk of developing type 1 diabetes has been temporally associated with development of pancreatic islet autoantibodies. In this study, nonobese diabetic mice were shown to be susceptible to rhesus rotavirus infection and pancreatic islets from nonobese diabetic mice, nonobese diabetes-resistant mice, fetal pigs, and macaque monkeys supported various degrees of rotavirus growth. Human rotaviruses replicated in monkey islets only. This islet susceptibility shows that rotavirus infection of the pancreas in vivo might be possible.

  • Copyright © 2002 American Society for Microbiology
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Growth of Rotaviruses in Primary Pancreatic Cells
Barbara S. Coulson, Paul D. Witterick, Yan Tan, Marilyn J. Hewish, Joanne N. Mountford, Leonard C. Harrison, Margo C. Honeyman
Journal of Virology Sep 2002, 76 (18) 9537-9544; DOI: 10.1128/JVI.76.18.9537-9544.2002

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Growth of Rotaviruses in Primary Pancreatic Cells
Barbara S. Coulson, Paul D. Witterick, Yan Tan, Marilyn J. Hewish, Joanne N. Mountford, Leonard C. Harrison, Margo C. Honeyman
Journal of Virology Sep 2002, 76 (18) 9537-9544; DOI: 10.1128/JVI.76.18.9537-9544.2002
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    • ABSTRACT
    • RRV infects NOD mice.
    • Monkey, but not human, rotaviruses replicate to a high titer in NOD mouse islets.
    • RRV replicates to higher titers in NOD mouse islets than in NOR mouse islets.
    • Monkey, but not human, rotaviruses replicate in porcine islets.
    • Human and monkey rotaviruses replicate in monkey islets.
    • Relative growth of rotaviruses in islets of different species.
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
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KEYWORDS

Islets of Langerhans
Pancreas
rotavirus
virus replication

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