DOI: 10.1128/JVI.76.18.9537-9544.2002
ABSTRACT
Rotavirus infection in children at risk of developing type 1 diabetes has been temporally associated with development of pancreatic islet autoantibodies. In this study, nonobese diabetic mice were shown to be susceptible to rhesus rotavirus infection and pancreatic islets from nonobese diabetic mice, nonobese diabetes-resistant mice, fetal pigs, and macaque monkeys supported various degrees of rotavirus growth. Human rotaviruses replicated in monkey islets only. This islet susceptibility shows that rotavirus infection of the pancreas in vivo might be possible.
FOOTNOTES
- Received 26 November 2001.
- Accepted 12 June 2002.
- ↵*Corresponding author. Mailing address: Department of Microbiology and Immunology, The University of Melbourne, Royal Parade, Victoria 3010, Australia. Phone: 61 3 8344 8823. Fax: 61 3 9347 1540. E-mail: barbarac{at}unimelb.edu.au.
- American Society for Microbiology
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- Article
- ABSTRACT
- RRV infects NOD mice.
- Monkey, but not human, rotaviruses replicate to a high titer in NOD mouse islets.
- RRV replicates to higher titers in NOD mouse islets than in NOR mouse islets.
- Monkey, but not human, rotaviruses replicate in porcine islets.
- Human and monkey rotaviruses replicate in monkey islets.
- Relative growth of rotaviruses in islets of different species.
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