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Viral Late Domains

Eric O. Freed
Eric O. Freed
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0460
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  • For correspondence: EFreed@nih.gov
DOI: 10.1128/JVI.76.10.4679-4687.2002
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    FIG. 1.

    Location of L domains in retroviral Gag proteins and in the matrix proteins of the rhabdoviruses and filoviruses. The retroviral Gag proteins that harbor L domains are shown in red; matrix, capsid, and nucleocapsid proteins are depicted in green, blue, and yellow, respectively. L domain motifs (PTAP, PPXY, and YXXL) are indicated.

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    FIG. 2.

    EM analysis of HIV-1 L domain defects. (A) Effect of HIV-1 L domain mutation on virus budding. Virus expression was directed by WT pNL4-3 and a p6 mutant derivative truncated at p6 amino acid 1 (L1Term [36]). Budding from HeLa cells and the Jurkat T-cell line is shown. Adapted from reference 13. (B) Effect of TSG-5′ overexpression on HIV-1 budding. HeLa cells were transfected with pNL4-3 alone (WT) or cotransfected with pNL4-3 plus TSG-5′ (WT + TSG-5′). Adapted with permission from reference 12. In panels A and B, closed arrows indicate virus particles tethered to the plasma membrane; open arrows highlight virion-virion tethers. Bar, 100 nm.

  • FIG. 3.
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    FIG. 3.

    Schematic organization of TSG101 and Nedd4. Domains (described in the text) are indicated. Diagram is not intended to be to scale.

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Viral Late Domains
Eric O. Freed
Journal of Virology May 2002, 76 (10) 4679-4687; DOI: 10.1128/JVI.76.10.4679-4687.2002

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Viral Late Domains
Eric O. Freed
Journal of Virology May 2002, 76 (10) 4679-4687; DOI: 10.1128/JVI.76.10.4679-4687.2002
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  • Top
  • Article
    • IDENTIFICATION OF L DOMAINS BY MUTAGENESIS
    • RSV: the PPXY prototype.
    • EIAV: requirement for a YXXL motif.
    • A diversity of phenotypes.
    • HOST FACTORS AND L DOMAIN FUNCTION
    • CONCLUDING REMARKS
    • ACKNOWLEDGMENTS
    • REFERENCES
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KEYWORDS

Gene Products, gag
Protein Structure, Tertiary
Retroviridae
Ubiquitin-Protein Ligases
virus assembly

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