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Pathogenesis and Immunity

Essential Roles for CD8+ T Cells and Gamma Interferon in Protection of Mice against Retrovirus-Induced Immunosuppression

Ulf Dittmer, Brent Race, Karin E. Peterson, Ingunn M. Stromnes, Ronald J. Messer, Kim J. Hasenkrug
Ulf Dittmer
1Institut für Virologie der Universität Würzburg, Würzburg, Germany
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Brent Race
2Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana
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Karin E. Peterson
2Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana
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Ingunn M. Stromnes
2Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana
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Ronald J. Messer
2Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana
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Kim J. Hasenkrug
2Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana
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  • For correspondence: khasenkrug@nih.gov
DOI: 10.1128/JVI.76.1.450-454.2002
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ABSTRACT

It is known that both animal and human retroviruses typically cause immunosuppression in their respective hosts, but the mechanisms by which this occurs are poorly understood. The present study uses Friend virus (FV) infections of mice as a model to determine how major histocompatibility complex (MHC) genes influence immunosuppression. Previously, MHC-I genes were shown to influence antibody responses to potent antigenic challenges given during acute FV infection. The mapping of an immune response to an MHC-I gene implicated CD8+ T cells in the mechanism, so we directly tested for their role by using in vivo CD8+ T-cell depletions. Mice resistant to FV-induced immunosuppression became susceptible when they were depleted of CD8+ T cells. Resistance also required gamma interferon (IFN-γ), as in vivo neutralization of IFN-γ converted mice from a resistant to susceptible phenotype. On the other hand, susceptibility to FV-induced immunosuppression was dependent on the immunosuppressive cytokine, interleukin-10 (IL-10), as antibody responses were restored in susceptible mice when IL-10 function was blocked in vivo. Thus, FV-induced immunosuppression of antibody responses involves complex mechanisms controlled at least in part by CD8+ T cells.

  • Copyright © 2002 American Society for Microbiology
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Essential Roles for CD8+ T Cells and Gamma Interferon in Protection of Mice against Retrovirus-Induced Immunosuppression
Ulf Dittmer, Brent Race, Karin E. Peterson, Ingunn M. Stromnes, Ronald J. Messer, Kim J. Hasenkrug
Journal of Virology Jan 2002, 76 (1) 450-454; DOI: 10.1128/JVI.76.1.450-454.2002

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Essential Roles for CD8+ T Cells and Gamma Interferon in Protection of Mice against Retrovirus-Induced Immunosuppression
Ulf Dittmer, Brent Race, Karin E. Peterson, Ingunn M. Stromnes, Ronald J. Messer, Kim J. Hasenkrug
Journal of Virology Jan 2002, 76 (1) 450-454; DOI: 10.1128/JVI.76.1.450-454.2002
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KEYWORDS

CD8-Positive T-Lymphocytes
Immunologic Deficiency Syndromes
Interferon-gamma
Retroviridae
Retroviridae Infections

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