ABSTRACT
A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the potential of recombinant NDV as a vaccine vector.
FOOTNOTES
- Received 4 May 2001.
- Accepted 4 September 2001.
↵* Corresponding author. Mailing address: Department of Microbiology, Mount Sinai School of Medicine, One Gustave Levy Pl., New York, NY 10029. Phone for Peter Palese: (212) 241-7318. Fax: (212) 722-3634. E-mail: peter.palese{at}mssm.edu. Phone for Adolfo Garcı́a-Sastre: (212) 241-7769. Fax: (212) 534-1684. E-mail:adolfo.garcia-sastre{at}mssm.edu.
- Copyright © 2001 American Society for Microbiology
