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Vaccines and Antiviral Agents

Recombinant Newcastle Disease Virus as a Vaccine Vector

Takaaki Nakaya, Jerome Cros, Man-Seong Park, Yurie Nakaya, Hongyong Zheng, Ana Sagrera, Enrique Villar, Adolfo Garcı́a-Sastre, Peter Palese
Takaaki Nakaya
Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029,and
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Jerome Cros
Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029,and
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Man-Seong Park
Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029,and
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Yurie Nakaya
Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029,and
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Hongyong Zheng
Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029,and
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Ana Sagrera
Department of Biochemistry and Molecular Biology, University of Salamanca, Salamanca, Spain
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Enrique Villar
Department of Biochemistry and Molecular Biology, University of Salamanca, Salamanca, Spain
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Adolfo Garcı́a-Sastre
Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029,and
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Peter Palese
Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029,and
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DOI: 10.1128/JVI.75.23.11868-11873.2001
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ABSTRACT

A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the potential of recombinant NDV as a vaccine vector.

  • Copyright © 2001 American Society for Microbiology
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Recombinant Newcastle Disease Virus as a Vaccine Vector
Takaaki Nakaya, Jerome Cros, Man-Seong Park, Yurie Nakaya, Hongyong Zheng, Ana Sagrera, Enrique Villar, Adolfo Garcı́a-Sastre, Peter Palese
Journal of Virology Dec 2001, 75 (23) 11868-11873; DOI: 10.1128/JVI.75.23.11868-11873.2001

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Recombinant Newcastle Disease Virus as a Vaccine Vector
Takaaki Nakaya, Jerome Cros, Man-Seong Park, Yurie Nakaya, Hongyong Zheng, Ana Sagrera, Enrique Villar, Adolfo Garcı́a-Sastre, Peter Palese
Journal of Virology Dec 2001, 75 (23) 11868-11873; DOI: 10.1128/JVI.75.23.11868-11873.2001
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KEYWORDS

Genetic Vectors
Newcastle disease virus
Recombination, Genetic

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