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Pathogenesis and Immunity

Differential Expression of Interleukin-2 and Gamma Interferon in Human Immunodeficiency Virus Disease

Scott F. Sieg, Douglas A. Bazdar, Clifford V. Harding, Michael M. Lederman
Scott F. Sieg
Department of Medicine, Division of Infectious Diseases, and
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Douglas A. Bazdar
Department of Medicine, Division of Infectious Diseases, and
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Clifford V. Harding
Department of Pathology, Center for AIDS Research, Case Western Reserve University, Cleveland, Ohio 44106
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Michael M. Lederman
Department of Medicine, Division of Infectious Diseases, and
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DOI: 10.1128/JVI.75.20.9983-9985.2001
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ABSTRACT

Subnormal T-cell production of interleukin-2 (IL-2) in human immunodeficiency virus (HIV) disease has been described; however, it is not clear whether failure to synthesize IL-2 represents a selective or global defect in T-cell cytokine production. We evaluated the intracellular production of gamma interferon (IFN-γ) and IL-2 in CD4+ cells that were stimulated with staphylococcal enterotoxin B or cytomegalovirus antigen. Strikingly, IFN-γ and IL-2 are differentially regulated in T cells of HIV-infected patients such that the numbers of CD69+ cells or IFN-γ-positive cells that make IL-2 are proportionally decreased in CD4+ T cells from HIV-infected patients. These findings demonstrate a selective defect in IL-2 production and suggest that enumeration of IFN-γ-producing cells in response to T-cell receptor stimulation, while providing some estimate of antigen-reactive cell frequency, may not reflect or predict “normal” T-cell function in HIV-infected patients.

  • Copyright © 2001 American Society for Microbiology
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Differential Expression of Interleukin-2 and Gamma Interferon in Human Immunodeficiency Virus Disease
Scott F. Sieg, Douglas A. Bazdar, Clifford V. Harding, Michael M. Lederman
Journal of Virology Oct 2001, 75 (20) 9983-9985; DOI: 10.1128/JVI.75.20.9983-9985.2001

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Differential Expression of Interleukin-2 and Gamma Interferon in Human Immunodeficiency Virus Disease
Scott F. Sieg, Douglas A. Bazdar, Clifford V. Harding, Michael M. Lederman
Journal of Virology Oct 2001, 75 (20) 9983-9985; DOI: 10.1128/JVI.75.20.9983-9985.2001
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KEYWORDS

CD4-Positive T-Lymphocytes
HIV Infections
Interferon-gamma
Interleukin-2

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