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Structure and Assembly

Assembly of the Herpes Simplex Virus Procapsid from Purified Components and Identification of Small Complexes Containing the Major Capsid and Scaffolding Proteins

William W. Newcomb, Fred L. Homa, Darrell R. Thomsen, Benes L. Trus, Naiqian Cheng, Alasdair Steven, Frank Booy, Jay C. Brown
William W. Newcomb
Department of Microbiology and Cancer Center, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908;
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Fred L. Homa
Infectious Disease Research, Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001; and
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Darrell R. Thomsen
Infectious Disease Research, Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001; and
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Benes L. Trus
Laboratory of Structural Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, and
Computational Bioscience and Engineering Laboratory, Center for Information Technology, National Institutes of Health, and
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Naiqian Cheng
Laboratory of Structural Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, and
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Alasdair Steven
Laboratory of Structural Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, and
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Frank Booy
Biomedical Engineering and Instrumentation Program, National Center for Research Resources,Bethesda, Maryland 20892
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Jay C. Brown
Department of Microbiology and Cancer Center, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908;
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DOI: 10.1128/JVI.73.5.4239-4250.1999
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Article Information

DOI 
https://doi.org/10.1128/JVI.73.5.4239-4250.1999
PubMed 
10196320

Published By 
American Society for Microbiology Journals
History 
  • Received November 23, 1998
  • Accepted February 9, 1999
  • Published online May 1, 1999.

Copyright & Usage 
Copyright © 1999 American Society for Microbiology

Author Information

  1. William W. Newcomb1,
  2. Fred L. Homa2,
  3. Darrell R. Thomsen2,
  4. Benes L. Trus3,4,
  5. Naiqian Cheng3,
  6. Alasdair Steven3,
  7. Frank Booy5 and
  8. Jay C. Brown1*
  1. Department of Microbiology and Cancer Center, University of Virginia Health Sciences Center, Charlottesville, Virginia 229081;
  2. Infectious Disease Research, Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 490012; and
  3. Laboratory of Structural Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases,3 and
  4. Computational Bioscience and Engineering Laboratory, Center for Information Technology,4 National Institutes of Health, and
  5. Biomedical Engineering and Instrumentation Program, National Center for Research Resources,5Bethesda, Maryland 20892
  • ↵* Corresponding author. Mailing address: Department of Microbiology, Box 441, University of Virginia Health Sciences Center, Charlottesville, VA 22908. Phone: (804) 924-1814. Fax: (804) 982-1071. E-mail:JCB2G{at}AVERY.MED.VIRGINIA.EDU.

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Assembly of the Herpes Simplex Virus Procapsid from Purified Components and Identification of Small Complexes Containing the Major Capsid and Scaffolding Proteins
William W. Newcomb, Fred L. Homa, Darrell R. Thomsen, Benes L. Trus, Naiqian Cheng, Alasdair Steven, Frank Booy, Jay C. Brown
Journal of Virology May 1999, 73 (5) 4239-4250; DOI: 10.1128/JVI.73.5.4239-4250.1999

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Assembly of the Herpes Simplex Virus Procapsid from Purified Components and Identification of Small Complexes Containing the Major Capsid and Scaffolding Proteins
William W. Newcomb, Fred L. Homa, Darrell R. Thomsen, Benes L. Trus, Naiqian Cheng, Alasdair Steven, Frank Booy, Jay C. Brown
Journal of Virology May 1999, 73 (5) 4239-4250; DOI: 10.1128/JVI.73.5.4239-4250.1999
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KEYWORDS

capsid
Herpesvirus 1, Human
Protein Precursors
Viral Proteins
virus assembly

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