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Pathogenesis and Immunity

Identical 371-Base-Pair Deletion Mutations in the LAT Genes of Herpes Simplex Virus Type 1 McKrae and 17syn+ Result in Different In Vivo Reactivation Phenotypes

Jeannette M. Loutsch, Guey-Chuen Perng, James M. Hill, Xiaodong Zheng, Mary E. Marquart, Timothy M. Block, Homayon Ghiasi, Anthony B. Nesburn, Steven L. Wechsler
Jeannette M. Loutsch
LSU Eye Center, Department of Ophthalmology, Microbiology and Immunology, and Department of Pharmacology, Louisiana State University Medical Center School of Medicine, New Orleans, Louisiana 70112-2234;
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Guey-Chuen Perng
Ophthalmology Research Laboratories, Cedars-Sinai Medical Center Burns and Allen Research Institute, Los Angeles, California 90048;
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James M. Hill
LSU Eye Center, Department of Ophthalmology, Microbiology and Immunology, and Department of Pharmacology, Louisiana State University Medical Center School of Medicine, New Orleans, Louisiana 70112-2234;
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Xiaodong Zheng
LSU Eye Center, Department of Ophthalmology, Microbiology and Immunology, and Department of Pharmacology, Louisiana State University Medical Center School of Medicine, New Orleans, Louisiana 70112-2234;
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Mary E. Marquart
LSU Eye Center, Department of Ophthalmology, Microbiology and Immunology, and Department of Pharmacology, Louisiana State University Medical Center School of Medicine, New Orleans, Louisiana 70112-2234;
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Timothy M. Block
Jefferson Center for Biomedical Research, Thomas Jefferson College, Doylestown, Pennsylvania 18901; and
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Homayon Ghiasi
Ophthalmology Research Laboratories, Cedars-Sinai Medical Center Burns and Allen Research Institute, Los Angeles, California 90048;
Department of Ophthalmology, UCLA School of Medicine, Los Angeles, California 90024
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Anthony B. Nesburn
Ophthalmology Research Laboratories, Cedars-Sinai Medical Center Burns and Allen Research Institute, Los Angeles, California 90048;
Department of Ophthalmology, UCLA School of Medicine, Los Angeles, California 90024
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Steven L. Wechsler
Ophthalmology Research Laboratories, Cedars-Sinai Medical Center Burns and Allen Research Institute, Los Angeles, California 90048;
Department of Ophthalmology, UCLA School of Medicine, Los Angeles, California 90024
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DOI: 10.1128/JVI.73.1.767-771.1999
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Article Information

DOI 
https://doi.org/10.1128/JVI.73.1.767-771.1999
PubMed 
9847385

Published By 
American Society for Microbiology Journals
History 
  • Received August 25, 1998
  • Accepted October 13, 1998
  • Published online January 1, 1999.

Copyright & Usage 
Copyright © 1999 American Society for Microbiology

Author Information

  1. Jeannette M. Loutsch1,
  2. Guey-Chuen Perng2,
  3. James M. Hill1,
  4. Xiaodong Zheng1,
  5. Mary E. Marquart1,
  6. Timothy M. Block3,
  7. Homayon Ghiasi2,4,
  8. Anthony B. Nesburn2,4 and
  9. Steven L. Wechsler2,4*
  1. LSU Eye Center, Department of Ophthalmology, Microbiology and Immunology, and Department of Pharmacology, Louisiana State University Medical Center School of Medicine, New Orleans, Louisiana 70112-22341;
  2. Ophthalmology Research Laboratories, Cedars-Sinai Medical Center Burns and Allen Research Institute, Los Angeles, California 900482;
  3. Jefferson Center for Biomedical Research, Thomas Jefferson College, Doylestown, Pennsylvania 189013; and
  4. Department of Ophthalmology, UCLA School of Medicine, Los Angeles, California 900244
  • ↵* Corresponding author. Mailing address: Ophthalmology Research Laboratories, Cedars-Sinai Medical Center Burns and Allen Research Institute, Davis Bldg., Room 5072, 8700 Beverly Blvd., Los Angeles, CA 90048. Phone: (310) 855-6457 or (310) 855-6455. Fax: (310) 652-8411. E-mail: Wechsler{at}CSMC.EDU.

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Identical 371-Base-Pair Deletion Mutations in the LAT Genes of Herpes Simplex Virus Type 1 McKrae and 17syn+ Result in Different In Vivo Reactivation Phenotypes
Jeannette M. Loutsch, Guey-Chuen Perng, James M. Hill, Xiaodong Zheng, Mary E. Marquart, Timothy M. Block, Homayon Ghiasi, Anthony B. Nesburn, Steven L. Wechsler
Journal of Virology Jan 1999, 73 (1) 767-771; DOI: 10.1128/JVI.73.1.767-771.1999

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Identical 371-Base-Pair Deletion Mutations in the LAT Genes of Herpes Simplex Virus Type 1 McKrae and 17syn+ Result in Different In Vivo Reactivation Phenotypes
Jeannette M. Loutsch, Guey-Chuen Perng, James M. Hill, Xiaodong Zheng, Mary E. Marquart, Timothy M. Block, Homayon Ghiasi, Anthony B. Nesburn, Steven L. Wechsler
Journal of Virology Jan 1999, 73 (1) 767-771; DOI: 10.1128/JVI.73.1.767-771.1999
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KEYWORDS

Herpesvirus 1, Human
Virus Activation
Virus Latency

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