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VIRAL PATHOGENESIS AND IMMUNITY

The Latent Herpes Simplex Virus Type 1 Genome Copy Number in Individual Neurons Is Virus Strain Specific and Correlates with Reactivation

N. M. Sawtell, D. K. Poon, C. S. Tansky, R. L. Thompson
N. M. Sawtell
Division of Infectious Diseases, Children’s Hospital Medical Center, Cincinnati, Ohio 45229-3039, and
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D. K. Poon
Department of Molecular Genetics, Microbiology, and Biochemistry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267-0524
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C. S. Tansky
Division of Infectious Diseases, Children’s Hospital Medical Center, Cincinnati, Ohio 45229-3039, and
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R. L. Thompson
Department of Molecular Genetics, Microbiology, and Biochemistry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267-0524
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DOI: 10.1128/JVI.72.7.5343-5350.1998
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Article Information

DOI 
https://doi.org/10.1128/JVI.72.7.5343-5350.1998
PubMed 
9620987

Published By 
American Society for Microbiology Journals
History 
  • Received December 10, 1997
  • Accepted March 12, 1998
  • Published online July 1, 1998.

Copyright & Usage 
Copyright © 1998 American Society for Microbiology

Author Information

  1. N. M. Sawtell1,
  2. D. K. Poon2,
  3. C. S. Tansky1 and
  4. R. L. Thompson2*
  1. Division of Infectious Diseases, Children’s Hospital Medical Center, Cincinnati, Ohio 45229-3039,1 and
  2. Department of Molecular Genetics, Microbiology, and Biochemistry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267-05242
  • ↵* Corresponding author. Mailing address: University of Cincinnati Medical Center, Department of Molecular Genetics, Microbiology, and Biochemistry, 231 Bethesda Ave., Cincinnati, OH 45267-0524. Phone: (513) 558-0063. Fax: (513) 558-8474. E-mail:Richard.Thompson{at}UC.edu.

  • † Present address: NCI-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201.

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The Latent Herpes Simplex Virus Type 1 Genome Copy Number in Individual Neurons Is Virus Strain Specific and Correlates with Reactivation
N. M. Sawtell, D. K. Poon, C. S. Tansky, R. L. Thompson
Journal of Virology Jul 1998, 72 (7) 5343-5350; DOI: 10.1128/JVI.72.7.5343-5350.1998

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The Latent Herpes Simplex Virus Type 1 Genome Copy Number in Individual Neurons Is Virus Strain Specific and Correlates with Reactivation
N. M. Sawtell, D. K. Poon, C. S. Tansky, R. L. Thompson
Journal of Virology Jul 1998, 72 (7) 5343-5350; DOI: 10.1128/JVI.72.7.5343-5350.1998
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KEYWORDS

DNA, Viral
Gene Dosage
Genome, Viral
Herpesvirus 1, Human
neurons
Virus Activation

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