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VIRAL PATHOGENESIS AND IMMUNITY

Neutralization of Human Immunodeficiency Virus Type 1 by Antibody to gp120 Is Determined Primarily by Occupancy of Sites on the Virion Irrespective of Epitope Specificity

Paul W. H. I. Parren, Isabelle Mondor, Denise Naniche, Henrik J. Ditzel, P. J. Klasse, Dennis R. Burton, Quentin J. Sattentau
Paul W. H. I. Parren
Departments of Immunology and Molecular Biology and
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Isabelle Mondor
Centre d’Immunologie de Marseille-Luminy, 13288 Marseille, France; and
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Denise Naniche
Division of Virology, The Scripps Research Institute, La Jolla, California 92037;
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Henrik J. Ditzel
Departments of Immunology and Molecular Biology and
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P. J. Klasse
The MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, United Kingdom
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Dennis R. Burton
Departments of Immunology and Molecular Biology and
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Quentin J. Sattentau
Centre d’Immunologie de Marseille-Luminy, 13288 Marseille, France; and
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DOI: 10.1128/JVI.72.5.3512-3519.1998
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Article Information

DOI 
https://doi.org/10.1128/JVI.72.5.3512-3519.1998
PubMed 
9557629

Published By 
American Society for Microbiology Journals
History 
  • Received September 2, 1997
  • Accepted January 12, 1998
  • Published online May 1, 1998.

Copyright & Usage 
Copyright © 1998 American Society for Microbiology

Author Information

  1. Paul W. H. I. Parren1,
  2. Isabelle Mondor2,
  3. Denise Naniche3,
  4. Henrik J. Ditzel1,
  5. P. J. Klasse4,
  6. Dennis R. Burton1* and
  7. Quentin J. Sattentau2*
  1. Departments of Immunology and Molecular Biology1 and
  2. Division of Virology,3 The Scripps Research Institute, La Jolla, California 92037;
  3. Centre d’Immunologie de Marseille-Luminy, 13288 Marseille, France2; and
  4. The MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, United Kingdom4
  • ↵* Corresponding author. Mailing address for Dennis R. Burton: Department of Immunology, IMM2, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037. Phone: (619) 784-9298. Fax: (619) 784-8360. E-mail: burton{at}scripps.edu. Mailing address for Quentin J. Sattentau: Centre d’Immunologie de Marseille-Luminy, Case 906, 13288 Marseille Cedex 9, France. Phone: (33) 4 491 26 94 94. Fax: (33) 4 491 26 94 30. E-mail:sattenta{at}ciml.univ-mrs.fr.

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Neutralization of Human Immunodeficiency Virus Type 1 by Antibody to gp120 Is Determined Primarily by Occupancy of Sites on the Virion Irrespective of Epitope Specificity
Paul W. H. I. Parren, Isabelle Mondor, Denise Naniche, Henrik J. Ditzel, P. J. Klasse, Dennis R. Burton, Quentin J. Sattentau
Journal of Virology May 1998, 72 (5) 3512-3519; DOI: 10.1128/JVI.72.5.3512-3519.1998

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Neutralization of Human Immunodeficiency Virus Type 1 by Antibody to gp120 Is Determined Primarily by Occupancy of Sites on the Virion Irrespective of Epitope Specificity
Paul W. H. I. Parren, Isabelle Mondor, Denise Naniche, Henrik J. Ditzel, P. J. Klasse, Dennis R. Burton, Quentin J. Sattentau
Journal of Virology May 1998, 72 (5) 3512-3519; DOI: 10.1128/JVI.72.5.3512-3519.1998
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KEYWORDS

Epitopes, B-Lymphocyte
HIV Antibodies
HIV Envelope Protein gp120
HIV-1

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